The incidence of antiphospholipid syndrome (APS) in Nigeria is not well-defined. Concomitant occurrence of APS and systemic lupus erythematosus (SLE) is rare in Nigeria. Documented here is a case of APS associated with SLE, complicated by lupus nephritis, in a young woman in Nigeria. Patient was a 31-year-old woman on evaluation for 2 consecutive mid-trimester pregnancy losses, each preceded by a history of leg swelling and passage of blood in urine. Two of her sisters, about her age, have a similar history of recurrent mid-trimester pregnancy losses. Her blood pressure was normal. She has proteinuria +++, 24-hour urine protein 2942mg, and positive serology results for ANA, dsDNA, antiphospholipid antibody, and lupus anticoagulant. She was placed on Aspirin and Prednisolone, among others. Repeat urine protein was 1242mg/day at 4 weeks and 419mg/day at 12 weeks on follow-up. This case report highlights the need for consideration of the possibility of APS in association with SLE in the evaluation of miscarriages and proteinuric diseases in pregnancy.
| Published in | Cardiology and Cardiovascular Research (Volume 1, Issue 3) |
| DOI | 10.11648/j.ccr.20170103.14 |
| Page(s) | 91-93 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2017. Published by Science Publishing Group |
Antiphospholipid Syndrome, Systemic Lupus Erythematosus, Lupus Nephritis, Miscarriage, Proteinuria in Pregnancy, Hematuria in Pregnancy, Nigeria
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APA Style
Ernest Ndukaife Anyabolu. (2017). Antiphospholipid Syndrome Associated with Lupus Nephritis in a Resource-Poor Setting: A Case Report in Orlu, Nigeria. Cardiology and Cardiovascular Research, 1(3), 91-93. https://doi.org/10.11648/j.ccr.20170103.14
ACS Style
Ernest Ndukaife Anyabolu. Antiphospholipid Syndrome Associated with Lupus Nephritis in a Resource-Poor Setting: A Case Report in Orlu, Nigeria. Cardiol. Cardiovasc. Res. 2017, 1(3), 91-93. doi: 10.11648/j.ccr.20170103.14
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Download@article{10.11648/j.ccr.20170103.14,
author = {Ernest Ndukaife Anyabolu},
title = {Antiphospholipid Syndrome Associated with Lupus Nephritis in a Resource-Poor Setting: A Case Report in Orlu, Nigeria},
journal = {Cardiology and Cardiovascular Research},
volume = {1},
number = {3},
pages = {91-93},
doi = {10.11648/j.ccr.20170103.14},
url = {https://doi.org/10.11648/j.ccr.20170103.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ccr.20170103.14},
abstract = {The incidence of antiphospholipid syndrome (APS) in Nigeria is not well-defined. Concomitant occurrence of APS and systemic lupus erythematosus (SLE) is rare in Nigeria. Documented here is a case of APS associated with SLE, complicated by lupus nephritis, in a young woman in Nigeria. Patient was a 31-year-old woman on evaluation for 2 consecutive mid-trimester pregnancy losses, each preceded by a history of leg swelling and passage of blood in urine. Two of her sisters, about her age, have a similar history of recurrent mid-trimester pregnancy losses. Her blood pressure was normal. She has proteinuria +++, 24-hour urine protein 2942mg, and positive serology results for ANA, dsDNA, antiphospholipid antibody, and lupus anticoagulant. She was placed on Aspirin and Prednisolone, among others. Repeat urine protein was 1242mg/day at 4 weeks and 419mg/day at 12 weeks on follow-up. This case report highlights the need for consideration of the possibility of APS in association with SLE in the evaluation of miscarriages and proteinuric diseases in pregnancy.},
year = {2017}
}
TY - JOUR T1 - Antiphospholipid Syndrome Associated with Lupus Nephritis in a Resource-Poor Setting: A Case Report in Orlu, Nigeria AU - Ernest Ndukaife Anyabolu Y1 - 2017/07/24 PY - 2017 N1 - https://doi.org/10.11648/j.ccr.20170103.14 DO - 10.11648/j.ccr.20170103.14 T2 - Cardiology and Cardiovascular Research JF - Cardiology and Cardiovascular Research JO - Cardiology and Cardiovascular Research SP - 91 EP - 93 PB - Science Publishing Group SN - 2578-8914 UR - https://doi.org/10.11648/j.ccr.20170103.14 AB - The incidence of antiphospholipid syndrome (APS) in Nigeria is not well-defined. Concomitant occurrence of APS and systemic lupus erythematosus (SLE) is rare in Nigeria. Documented here is a case of APS associated with SLE, complicated by lupus nephritis, in a young woman in Nigeria. Patient was a 31-year-old woman on evaluation for 2 consecutive mid-trimester pregnancy losses, each preceded by a history of leg swelling and passage of blood in urine. Two of her sisters, about her age, have a similar history of recurrent mid-trimester pregnancy losses. Her blood pressure was normal. She has proteinuria +++, 24-hour urine protein 2942mg, and positive serology results for ANA, dsDNA, antiphospholipid antibody, and lupus anticoagulant. She was placed on Aspirin and Prednisolone, among others. Repeat urine protein was 1242mg/day at 4 weeks and 419mg/day at 12 weeks on follow-up. This case report highlights the need for consideration of the possibility of APS in association with SLE in the evaluation of miscarriages and proteinuric diseases in pregnancy. VL - 1 IS - 3 ER -
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