Mechanisms of Iron Deficiency in Obese Children

Xin-yan Yan

doi:doi:10.11648/j.cmr.20231205.12

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Mechanisms of Iron Deficiency in Obese Children

Xin-yan Yan

Published in Clinical Medicine Research (Volume 12, Issue 5)

Received: 8 September 2023 Accepted: 4 October 2023 Published: 14 October 2023

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Abstract

Obesity and iron deficiency are global public health problems. Obesity can cause nutritional disorders, such as iron deficiency. Obesity and iron deficiency during the rapid stages of growth and development in children can cause lasting and irreversible damage to the health of children and even into adulthood. Because the economy and living standards are improving, the incidence of childhood obesity increases yearly, at the same time, the incidence of iron deficiency in obese children is also higher. Obesity is closely related to the occurrence and development of iron deficiency, and the coexistence of the two can produce synergistic effects leading to serious harm, which is an urgent nutritional health problem in clinic. By impairing iron absorption, reducing iron excretion within cells, and by competing with the body for iron with the altered gut flora caused by obesity, obesity can disrupt the normal iron metabolism process and then lead to iron deficiency. The mechanism of obesity-associated iron deficiency is complex and may be related to inflammatory response, intestinal cells, anoxic microenvironment and intestinal flora. Therefore, in this review, we discuss possible mechanisms of obesity-associated iron deficiency to offer new methods and strategies for preventing and treating iron deficiency in obese children.

Published in	Clinical Medicine Research (Volume 12, Issue 5)
DOI	10.11648/j.cmr.20231205.12
Page(s)	95-102
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Obesity, Iron Deficiency, Anoxic Microenvironment, Inflammation, Gut Microbiota

References

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Xin-yan Yan. (2023). Mechanisms of Iron Deficiency in Obese Children. Clinical Medicine Research, 12(5), 95-102. https://doi.org/10.11648/j.cmr.20231205.12

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Xin-yan Yan. Mechanisms of Iron Deficiency in Obese Children. Clin. Med. Res. 2023, 12(5), 95-102. doi: 10.11648/j.cmr.20231205.12

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Xin-yan Yan. Mechanisms of Iron Deficiency in Obese Children. Clin Med Res. 2023;12(5):95-102. doi: 10.11648/j.cmr.20231205.12

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@article{10.11648/j.cmr.20231205.12,
  author = {Xin-yan Yan},
  title = {Mechanisms of Iron Deficiency in Obese Children},
  journal = {Clinical Medicine Research},
  volume = {12},
  number = {5},
  pages = {95-102},
  doi = {10.11648/j.cmr.20231205.12},
  url = {https://doi.org/10.11648/j.cmr.20231205.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20231205.12},
  abstract = {Obesity and iron deficiency are global public health problems. Obesity can cause nutritional disorders, such as iron deficiency. Obesity and iron deficiency during the rapid stages of growth and development in children can cause lasting and irreversible damage to the health of children and even into adulthood. Because the economy and living standards are improving, the incidence of childhood obesity increases yearly, at the same time, the incidence of iron deficiency in obese children is also higher. Obesity is closely related to the occurrence and development of iron deficiency, and the coexistence of the two can produce synergistic effects leading to serious harm, which is an urgent nutritional health problem in clinic. By impairing iron absorption, reducing iron excretion within cells, and by competing with the body for iron with the altered gut flora caused by obesity, obesity can disrupt the normal iron metabolism process and then lead to iron deficiency. The mechanism of obesity-associated iron deficiency is complex and may be related to inflammatory response, intestinal cells, anoxic microenvironment and intestinal flora. Therefore, in this review, we discuss possible mechanisms of obesity-associated iron deficiency to offer new methods and strategies for preventing and treating iron deficiency in obese children.},
 year = {2023}
}

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TY  - JOUR
T1  - Mechanisms of Iron Deficiency in Obese Children
AU  - Xin-yan Yan
Y1  - 2023/10/14
PY  - 2023
N1  - https://doi.org/10.11648/j.cmr.20231205.12
DO  - 10.11648/j.cmr.20231205.12
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 95
EP  - 102
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20231205.12
AB  - Obesity and iron deficiency are global public health problems. Obesity can cause nutritional disorders, such as iron deficiency. Obesity and iron deficiency during the rapid stages of growth and development in children can cause lasting and irreversible damage to the health of children and even into adulthood. Because the economy and living standards are improving, the incidence of childhood obesity increases yearly, at the same time, the incidence of iron deficiency in obese children is also higher. Obesity is closely related to the occurrence and development of iron deficiency, and the coexistence of the two can produce synergistic effects leading to serious harm, which is an urgent nutritional health problem in clinic. By impairing iron absorption, reducing iron excretion within cells, and by competing with the body for iron with the altered gut flora caused by obesity, obesity can disrupt the normal iron metabolism process and then lead to iron deficiency. The mechanism of obesity-associated iron deficiency is complex and may be related to inflammatory response, intestinal cells, anoxic microenvironment and intestinal flora. Therefore, in this review, we discuss possible mechanisms of obesity-associated iron deficiency to offer new methods and strategies for preventing and treating iron deficiency in obese children.
VL  - 12
IS  - 5
ER  -

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Xin-yan Yan

Department of Pediatrics, Chengdu Fifth People’s Hospital, Chengdu, China

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Xin-yan Yan. (2023). Mechanisms of Iron Deficiency in Obese Children. Clinical Medicine Research, 12(5), 95-102. https://doi.org/10.11648/j.cmr.20231205.12

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ACS Style

Xin-yan Yan. Mechanisms of Iron Deficiency in Obese Children. Clin. Med. Res. 2023, 12(5), 95-102. doi: 10.11648/j.cmr.20231205.12

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AMA Style

Xin-yan Yan. Mechanisms of Iron Deficiency in Obese Children. Clin Med Res. 2023;12(5):95-102. doi: 10.11648/j.cmr.20231205.12

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@article{10.11648/j.cmr.20231205.12,
  author = {Xin-yan Yan},
  title = {Mechanisms of Iron Deficiency in Obese Children},
  journal = {Clinical Medicine Research},
  volume = {12},
  number = {5},
  pages = {95-102},
  doi = {10.11648/j.cmr.20231205.12},
  url = {https://doi.org/10.11648/j.cmr.20231205.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cmr.20231205.12},
  abstract = {Obesity and iron deficiency are global public health problems. Obesity can cause nutritional disorders, such as iron deficiency. Obesity and iron deficiency during the rapid stages of growth and development in children can cause lasting and irreversible damage to the health of children and even into adulthood. Because the economy and living standards are improving, the incidence of childhood obesity increases yearly, at the same time, the incidence of iron deficiency in obese children is also higher. Obesity is closely related to the occurrence and development of iron deficiency, and the coexistence of the two can produce synergistic effects leading to serious harm, which is an urgent nutritional health problem in clinic. By impairing iron absorption, reducing iron excretion within cells, and by competing with the body for iron with the altered gut flora caused by obesity, obesity can disrupt the normal iron metabolism process and then lead to iron deficiency. The mechanism of obesity-associated iron deficiency is complex and may be related to inflammatory response, intestinal cells, anoxic microenvironment and intestinal flora. Therefore, in this review, we discuss possible mechanisms of obesity-associated iron deficiency to offer new methods and strategies for preventing and treating iron deficiency in obese children.},
 year = {2023}
}

Copy | Download

TY  - JOUR
T1  - Mechanisms of Iron Deficiency in Obese Children
AU  - Xin-yan Yan
Y1  - 2023/10/14
PY  - 2023
N1  - https://doi.org/10.11648/j.cmr.20231205.12
DO  - 10.11648/j.cmr.20231205.12
T2  - Clinical Medicine Research
JF  - Clinical Medicine Research
JO  - Clinical Medicine Research
SP  - 95
EP  - 102
PB  - Science Publishing Group
SN  - 2326-9057
UR  - https://doi.org/10.11648/j.cmr.20231205.12
AB  - Obesity and iron deficiency are global public health problems. Obesity can cause nutritional disorders, such as iron deficiency. Obesity and iron deficiency during the rapid stages of growth and development in children can cause lasting and irreversible damage to the health of children and even into adulthood. Because the economy and living standards are improving, the incidence of childhood obesity increases yearly, at the same time, the incidence of iron deficiency in obese children is also higher. Obesity is closely related to the occurrence and development of iron deficiency, and the coexistence of the two can produce synergistic effects leading to serious harm, which is an urgent nutritional health problem in clinic. By impairing iron absorption, reducing iron excretion within cells, and by competing with the body for iron with the altered gut flora caused by obesity, obesity can disrupt the normal iron metabolism process and then lead to iron deficiency. The mechanism of obesity-associated iron deficiency is complex and may be related to inflammatory response, intestinal cells, anoxic microenvironment and intestinal flora. Therefore, in this review, we discuss possible mechanisms of obesity-associated iron deficiency to offer new methods and strategies for preventing and treating iron deficiency in obese children.
VL  - 12
IS  - 5
ER  -

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