Pancreatic cancer (PC) is a highly lethal form of cancer that presents significant challenges for early detection. It rapidly metastasizes and often shows resistance to conventional chemotherapy. Consequently, the prognosis for most patients is bleak. Despite substantial advances in medical research, the number of viable treatment options remains limited, highlighting the urgent need for innovative strategies to improve patient outcomes. Ferroptosis is a unique type of cell death triggered by excessive iron levels. It sets itself apart from other forms of cell death, such as apoptosis and necrosis, characterized by an overabundance of lipid peroxides and reactive oxygen species. Ferroptosis plays a critical role in sustaining the viability of healthy cells and tissues. However, specific cancerous cells are vulnerable to this process. The resistance of pancreatic cancer cells to chemotherapeutic drugs has become the main reason for chemotherapy failure. Inducing ferroptosis in cancer cells is the best way to overcome chemotherapy resistance. Small molecule drugs can cause iron death through glutathione depletion and lipid peroxidation. Ferroptosis inhibitors may become an adjuvant therapy enhancer, acting with ferroptosis inducers on pancreatic tumor cells. As such, the induction of ferroptosis may offer a promising new avenue for cancer treatment. This article examines PC's iron-induced cell death regulatory mechanism and potential therapeutic applications.
| Published in | International Journal of Biomedical Science and Engineering (Volume 11, Issue 4) |
| DOI | 10.11648/j.ijbse.20231104.12 |
| Page(s) | 54-60 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Ferroptosis, Pancreatic Cancer (PC), Glutathione Peroxidase 4 (GPX4), System XC, Tumor Microenvironment (TME)
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APA Style
Zhang, J., Zhao, Y. (2023). The Developments and Advancements in Ferroptosis Research for the Treatment of Pancreatic Cancer: A Review. International Journal of Biomedical Science and Engineering, 11(4), 54-60. https://doi.org/10.11648/j.ijbse.20231104.12
ACS Style
Zhang, J.; Zhao, Y. The Developments and Advancements in Ferroptosis Research for the Treatment of Pancreatic Cancer: A Review. Int. J. Biomed. Sci. Eng. 2023, 11(4), 54-60. doi: 10.11648/j.ijbse.20231104.12
AMA Style
Zhang J, Zhao Y. The Developments and Advancements in Ferroptosis Research for the Treatment of Pancreatic Cancer: A Review. Int J Biomed Sci Eng. 2023;11(4):54-60. doi: 10.11648/j.ijbse.20231104.12
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Download@article{10.11648/j.ijbse.20231104.12,
author = {Jingchang Zhang and Yongfu Zhao},
title = {The Developments and Advancements in Ferroptosis Research for the Treatment of Pancreatic Cancer: A Review},
journal = {International Journal of Biomedical Science and Engineering},
volume = {11},
number = {4},
pages = {54-60},
doi = {10.11648/j.ijbse.20231104.12},
url = {https://doi.org/10.11648/j.ijbse.20231104.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbse.20231104.12},
abstract = {Pancreatic cancer (PC) is a highly lethal form of cancer that presents significant challenges for early detection. It rapidly metastasizes and often shows resistance to conventional chemotherapy. Consequently, the prognosis for most patients is bleak. Despite substantial advances in medical research, the number of viable treatment options remains limited, highlighting the urgent need for innovative strategies to improve patient outcomes. Ferroptosis is a unique type of cell death triggered by excessive iron levels. It sets itself apart from other forms of cell death, such as apoptosis and necrosis, characterized by an overabundance of lipid peroxides and reactive oxygen species. Ferroptosis plays a critical role in sustaining the viability of healthy cells and tissues. However, specific cancerous cells are vulnerable to this process. The resistance of pancreatic cancer cells to chemotherapeutic drugs has become the main reason for chemotherapy failure. Inducing ferroptosis in cancer cells is the best way to overcome chemotherapy resistance. Small molecule drugs can cause iron death through glutathione depletion and lipid peroxidation. Ferroptosis inhibitors may become an adjuvant therapy enhancer, acting with ferroptosis inducers on pancreatic tumor cells. As such, the induction of ferroptosis may offer a promising new avenue for cancer treatment. This article examines PC's iron-induced cell death regulatory mechanism and potential therapeutic applications.
},
year = {2023}
}
TY - JOUR T1 - The Developments and Advancements in Ferroptosis Research for the Treatment of Pancreatic Cancer: A Review AU - Jingchang Zhang AU - Yongfu Zhao Y1 - 2023/12/06 PY - 2023 N1 - https://doi.org/10.11648/j.ijbse.20231104.12 DO - 10.11648/j.ijbse.20231104.12 T2 - International Journal of Biomedical Science and Engineering JF - International Journal of Biomedical Science and Engineering JO - International Journal of Biomedical Science and Engineering SP - 54 EP - 60 PB - Science Publishing Group SN - 2376-7235 UR - https://doi.org/10.11648/j.ijbse.20231104.12 AB - Pancreatic cancer (PC) is a highly lethal form of cancer that presents significant challenges for early detection. It rapidly metastasizes and often shows resistance to conventional chemotherapy. Consequently, the prognosis for most patients is bleak. Despite substantial advances in medical research, the number of viable treatment options remains limited, highlighting the urgent need for innovative strategies to improve patient outcomes. Ferroptosis is a unique type of cell death triggered by excessive iron levels. It sets itself apart from other forms of cell death, such as apoptosis and necrosis, characterized by an overabundance of lipid peroxides and reactive oxygen species. Ferroptosis plays a critical role in sustaining the viability of healthy cells and tissues. However, specific cancerous cells are vulnerable to this process. The resistance of pancreatic cancer cells to chemotherapeutic drugs has become the main reason for chemotherapy failure. Inducing ferroptosis in cancer cells is the best way to overcome chemotherapy resistance. Small molecule drugs can cause iron death through glutathione depletion and lipid peroxidation. Ferroptosis inhibitors may become an adjuvant therapy enhancer, acting with ferroptosis inducers on pancreatic tumor cells. As such, the induction of ferroptosis may offer a promising new avenue for cancer treatment. This article examines PC's iron-induced cell death regulatory mechanism and potential therapeutic applications. VL - 11 IS - 4 ER -
Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
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