Effects of β-Glucan on Natural Killer Cells in Patients Recovering from Cancer Treatment: Clinical Trial

Josef Richter; Vlastimil Kral; Jitka Pohorska; Lucie Rajnohova Dobiasova; Vaclav Vetvicka

doi:doi:10.11648/j.ijcems.20160202.12

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Effects of β-Glucan on Natural Killer Cells in Patients Recovering from Cancer Treatment: Clinical Trial

Josef Richter, Vlastimil Kral, Jitka Pohorska, Lucie Rajnohova Dobiasova, Vaclav Vetvicka

Published in International Journal of Clinical and Experimental Medical Sciences (Volume 2, Issue 2)

Received: 8 March 2016 Accepted: 11 March 2016 Published: 25 April 2016

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Abstract

Glucan is the most studied immunomodulator. Among its properties, effects on cancer are the closest to clinical use. In our study, we evaluated the effects of short-term supplementation with glucan on NK cells in patients recovering from different types of cancer treatment. NK cells represent a distinct sub-population of lymphocytes endowed with the capacity to kill tumor cells without prior sensitization and form one of the most important defense mechanisms against cancer. To measure the numbers of NK cells, flow cytometer measuring four colors was used. Using a double-blind, placebo-controlled clinical trial, we found that adding glucan to the diet strongly increased the number of NK cells in blood.

Published in	International Journal of Clinical and Experimental Medical Sciences (Volume 2, Issue 2)
DOI	10.11648/j.ijcems.20160202.12
Page(s)	26-30
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Cancer, Glucan, NK Cells, Immunity, Lymphocytes

References

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APA Style

Josef Richter, Vlastimil Kral, Jitka Pohorska, Lucie Rajnohova Dobiasova, Vaclav Vetvicka. (2016). Effects of β-Glucan on Natural Killer Cells in Patients Recovering from Cancer Treatment: Clinical Trial. International Journal of Clinical and Experimental Medical Sciences, 2(2), 26-30. https://doi.org/10.11648/j.ijcems.20160202.12

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ACS Style

Josef Richter; Vlastimil Kral; Jitka Pohorska; Lucie Rajnohova Dobiasova; Vaclav Vetvicka. Effects of β-Glucan on Natural Killer Cells in Patients Recovering from Cancer Treatment: Clinical Trial. Int. J. Clin. Exp. Med. Sci. 2016, 2(2), 26-30. doi: 10.11648/j.ijcems.20160202.12

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AMA Style

Josef Richter, Vlastimil Kral, Jitka Pohorska, Lucie Rajnohova Dobiasova, Vaclav Vetvicka. Effects of β-Glucan on Natural Killer Cells in Patients Recovering from Cancer Treatment: Clinical Trial. Int J Clin Exp Med Sci. 2016;2(2):26-30. doi: 10.11648/j.ijcems.20160202.12

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@article{10.11648/j.ijcems.20160202.12,
  author = {Josef Richter and Vlastimil Kral and Jitka Pohorska and Lucie Rajnohova Dobiasova and Vaclav Vetvicka},
  title = {Effects of β-Glucan on Natural Killer Cells in Patients Recovering from Cancer Treatment: Clinical Trial},
  journal = {International Journal of Clinical and Experimental Medical Sciences},
  volume = {2},
  number = {2},
  pages = {26-30},
  doi = {10.11648/j.ijcems.20160202.12},
  url = {https://doi.org/10.11648/j.ijcems.20160202.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20160202.12},
  abstract = {Glucan is the most studied immunomodulator. Among its properties, effects on cancer are the closest to clinical use. In our study, we evaluated the effects of short-term supplementation with glucan on NK cells in patients recovering from different types of cancer treatment. NK cells represent a distinct sub-population of lymphocytes endowed with the capacity to kill tumor cells without prior sensitization and form one of the most important defense mechanisms against cancer. To measure the numbers of NK cells, flow cytometer measuring four colors was used. Using a double-blind, placebo-controlled clinical trial, we found that adding glucan to the diet strongly increased the number of NK cells in blood.},
 year = {2016}
}

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TY  - JOUR
T1  - Effects of β-Glucan on Natural Killer Cells in Patients Recovering from Cancer Treatment: Clinical Trial
AU  - Josef Richter
AU  - Vlastimil Kral
AU  - Jitka Pohorska
AU  - Lucie Rajnohova Dobiasova
AU  - Vaclav Vetvicka
Y1  - 2016/04/25
PY  - 2016
N1  - https://doi.org/10.11648/j.ijcems.20160202.12
DO  - 10.11648/j.ijcems.20160202.12
T2  - International Journal of Clinical and Experimental Medical Sciences
JF  - International Journal of Clinical and Experimental Medical Sciences
JO  - International Journal of Clinical and Experimental Medical Sciences
SP  - 26
EP  - 30
PB  - Science Publishing Group
SN  - 2469-8032
UR  - https://doi.org/10.11648/j.ijcems.20160202.12
AB  - Glucan is the most studied immunomodulator. Among its properties, effects on cancer are the closest to clinical use. In our study, we evaluated the effects of short-term supplementation with glucan on NK cells in patients recovering from different types of cancer treatment. NK cells represent a distinct sub-population of lymphocytes endowed with the capacity to kill tumor cells without prior sensitization and form one of the most important defense mechanisms against cancer. To measure the numbers of NK cells, flow cytometer measuring four colors was used. Using a double-blind, placebo-controlled clinical trial, we found that adding glucan to the diet strongly increased the number of NK cells in blood.
VL  - 2
IS  - 2
ER  -

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Author Information

Josef Richter

Health Institute (Zdravotni ustav se sidlem) of Usti nad Labem, Usti nad Labem, Czech Republic
Vlastimil Kral

Health Institute (Zdravotni ustav se sidlem) of Usti nad Labem, Usti nad Labem, Czech Republic
Jitka Pohorska

Health Institute (Zdravotni ustav se sidlem) of Usti nad Labem, Usti nad Labem, Czech Republic
Lucie Rajnohova Dobiasova

Health Institute (Zdravotni ustav se sidlem) of Usti nad Labem, Usti nad Labem, Czech Republic
Vaclav Vetvicka

University of Louisville, Department of Pathology, Louisville, KY, USA

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Plain Text BibTeX RIS

APA Style

Josef Richter, Vlastimil Kral, Jitka Pohorska, Lucie Rajnohova Dobiasova, Vaclav Vetvicka. (2016). Effects of β-Glucan on Natural Killer Cells in Patients Recovering from Cancer Treatment: Clinical Trial. International Journal of Clinical and Experimental Medical Sciences, 2(2), 26-30. https://doi.org/10.11648/j.ijcems.20160202.12

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ACS Style

Josef Richter; Vlastimil Kral; Jitka Pohorska; Lucie Rajnohova Dobiasova; Vaclav Vetvicka. Effects of β-Glucan on Natural Killer Cells in Patients Recovering from Cancer Treatment: Clinical Trial. Int. J. Clin. Exp. Med. Sci. 2016, 2(2), 26-30. doi: 10.11648/j.ijcems.20160202.12

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AMA Style

Josef Richter, Vlastimil Kral, Jitka Pohorska, Lucie Rajnohova Dobiasova, Vaclav Vetvicka. Effects of β-Glucan on Natural Killer Cells in Patients Recovering from Cancer Treatment: Clinical Trial. Int J Clin Exp Med Sci. 2016;2(2):26-30. doi: 10.11648/j.ijcems.20160202.12

Copy | Download

@article{10.11648/j.ijcems.20160202.12,
  author = {Josef Richter and Vlastimil Kral and Jitka Pohorska and Lucie Rajnohova Dobiasova and Vaclav Vetvicka},
  title = {Effects of β-Glucan on Natural Killer Cells in Patients Recovering from Cancer Treatment: Clinical Trial},
  journal = {International Journal of Clinical and Experimental Medical Sciences},
  volume = {2},
  number = {2},
  pages = {26-30},
  doi = {10.11648/j.ijcems.20160202.12},
  url = {https://doi.org/10.11648/j.ijcems.20160202.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20160202.12},
  abstract = {Glucan is the most studied immunomodulator. Among its properties, effects on cancer are the closest to clinical use. In our study, we evaluated the effects of short-term supplementation with glucan on NK cells in patients recovering from different types of cancer treatment. NK cells represent a distinct sub-population of lymphocytes endowed with the capacity to kill tumor cells without prior sensitization and form one of the most important defense mechanisms against cancer. To measure the numbers of NK cells, flow cytometer measuring four colors was used. Using a double-blind, placebo-controlled clinical trial, we found that adding glucan to the diet strongly increased the number of NK cells in blood.},
 year = {2016}
}

Copy | Download

TY  - JOUR
T1  - Effects of β-Glucan on Natural Killer Cells in Patients Recovering from Cancer Treatment: Clinical Trial
AU  - Josef Richter
AU  - Vlastimil Kral
AU  - Jitka Pohorska
AU  - Lucie Rajnohova Dobiasova
AU  - Vaclav Vetvicka
Y1  - 2016/04/25
PY  - 2016
N1  - https://doi.org/10.11648/j.ijcems.20160202.12
DO  - 10.11648/j.ijcems.20160202.12
T2  - International Journal of Clinical and Experimental Medical Sciences
JF  - International Journal of Clinical and Experimental Medical Sciences
JO  - International Journal of Clinical and Experimental Medical Sciences
SP  - 26
EP  - 30
PB  - Science Publishing Group
SN  - 2469-8032
UR  - https://doi.org/10.11648/j.ijcems.20160202.12
AB  - Glucan is the most studied immunomodulator. Among its properties, effects on cancer are the closest to clinical use. In our study, we evaluated the effects of short-term supplementation with glucan on NK cells in patients recovering from different types of cancer treatment. NK cells represent a distinct sub-population of lymphocytes endowed with the capacity to kill tumor cells without prior sensitization and form one of the most important defense mechanisms against cancer. To measure the numbers of NK cells, flow cytometer measuring four colors was used. Using a double-blind, placebo-controlled clinical trial, we found that adding glucan to the diet strongly increased the number of NK cells in blood.
VL  - 2
IS  - 2
ER  -

Copy | Download