| Peer-Reviewed

Characterization of Medication Related Problems Among Patients with Cardiovascular Disease in Medical Ward of Mettu Karl Referral Hospital, South Western, Ethiopia: A Prospective Observational Study

Received: 28 June 2021     Accepted: 28 July 2021     Published: 4 August 2021
Views:       Downloads:
Abstract

Background: Medication related problem is defined as: ‘an event or circumstance involving drug therapy that actually or potentially interferes with desired health outcomes. Drug related problems are of a major concern in health care because of increased cost, morbidity and mortality. cardiovascular diseases are a group of disorders of the heart and blood vessels. Objective: To discover characterization of medication related problems and contributing factors among cardiovascular patients in the medical ward of Mettu Karl Referral Hospital. Methods: A facility based prospective observational study design was carried from April 07 /2021 to June 09/2021. Data was collected through employing check list and semi-structured questioner. Data was entered and descriptive statistical analysis was done using statistical packages for social sciences 25.0 version statistical software. Both bi-variable and multivariable analysis performed to determine the association between outcome and predictors variables. A p-value of less than 0.05 was considered significant. Results: The overall rate of medication related problems among cardiovascular patients in medical ward was 53 (58.2%). The patient’s age group was in line of 36-59 years 49 (53.8%). Unnecessary drug therapy 15 (28.3%) were the mostly identified type of drug therapy problem followed by dosage too high 11 (20.8%). ACEIs 229 (17.1%) was commonly prescribed medication and potassium sparing 19 (2.2%) was least prescribed drugs. Age ≥ 60 years (AOR: 2.76; 95%CI: 1.342-3.945; P=0.004), rural area residents (AOR: 2.76; 95%CI: 1.014-2.758; P=0.003), length of hospital stay >7 days (AO R: 4.75; 95%CI: 2.986-11.723; P=0.007), number of medication >5 (AOR: 3.632-17.893; 95%CI: 2.986-11.723; P=0.001) were associated factor significantly causes medication related problems. Conclusion and Recommendation: The prevalence of medication related problems amid cardiovascular patients in medical ward was high. Less than half of patients were found to have co-morbidities and were had have social substance users. Hospitals and ministry of Health should have to establish pharmaceutical care services for better patient care.

Published in International Journal of Cardiovascular and Thoracic Surgery (Volume 7, Issue 3)
DOI 10.11648/j.ijcts.20210703.11
Page(s) 34-40
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Medication Related Problems, Associated Factors, Cardiovascular Disease, Medical Ward, Mettu Karl Referral Hospital, Ethiopia

References
[1] Cipolle, R. J., Strand, L., & Morley, P. (2012). Drug therapy problems. Pharmaceutical Care Practice: The Patient-Centered Approach to Medication Management. 3rd edition. McGraw-Hill, 156-169.
[2] Hepler CD, Strand LM. Opportunities and responsibilities in pharmaceutical care. Am J Hosp Pharm. 1990 Mar; 47 (3): 533-43.
[3] van den Bemt PM, Egberts TC, de Jong-van den Berg LT, Brouwers JR. Drug- related problems in hospitalized patients. Drug Saf. 2000 Apr; 22 (4): 321-33.
[4] Pulido P, Cravioto A, Pereda A, Rondón R, Pereira G. Changes, trends and challenges of medical education in Latin America. Med Teach 2006, 28: 24-9.
[5] Gastelurrutia P, Benrimoj SI, Espejo J, Tuneu L, Mangues MA, Bayes-Genis A. Negat ive clinical outcomes associated with drug-related problems in heart failure (HF) outpatients: impact of a pharmacist in a multidisciplinary HF clinic. J Card Fail. 2011; 17 (3): 217–223.
[6] Frenk J, Chen L, Bhutta ZA, Cohen J, Crisp N, Evans T, et al. Health professionals for a new century: transforming education to strengthen health systems in an interdependent world. Lancet 2010; 376: 1923-58.
[7] Pan American Health Organization. Health conditions in the Americas. Scientific Publication. 524. Washington DC, PAHO/WHO, 1990.
[8] 1999 World Health Organization-International Society of Hypertension Guidelines for the Management of Hypertension. J Hypertens 1999; 17: 151–183.
[9] Nivya K, Sri V, Kiran S, Ragoo N, Jayaprakash B, Sekhar MS. Systemic review on drugrelatedhospitaladmissions–Apubmedbasedsearch. SaudiPharmJ. 2015; 23 (1): 1–8. https://doi. org/10.1016/j.jsps.2013.05.006PMID: 25685036.
[10] Redzuan A, Ramli A, Pheng M. Drug-Related Problems in Hypertensive Patients with Multiple Comorbidities. J Pharm Res. 2017; 1 (3): 000113.
[11] Farha RA, Basheti I, Al Ruz HA, Alsaleh A, AbuRuz S. Assessment of drug-related problems and their impact on blood pressure control in patients with hypertension. Eur J Hosp Pharm. 2016; 23 (3): 126-130.
[12] Gaziano TA. Cardiovascular disease in the developing world and its cost- effective management. Circulation. 2005 Dec 6; 112 (23): 3547-53.
[13] Adem A, Demis T, Feleke Y. Trend of diabetic admissions in Tikur Anbessa and St. Paul's University Teaching Hospitals from January 2005-December 2009, Addis Abab a, Ethiopia. Ethiop Med J. 2011 Jul; 49 (3): 231-8.
[14] Starfield B, Lemke KW, Bernhardt T, Foldes SS, Forrest CB, Weiner JP. Co- morbidi ty: implications for the importance of primary care in 'case' management. Ann Fam Med. 2003 May-Jun; 1 (1): 8-14.
[15] Van Den Bos J, Rustagi K, Gray T, Halford M, Ziemkiewicz E, Shreve J. The $17. 1 billion problem: the annual cost of measurable medical errors. Health Aff (Millwood). 2011 Apr; 30 (4): 596-603.
[16] Yimama M, Jarso H, Desse TA. Determinants of drug-related problems among ambulatory type 2 diabetes patients with hypertension comorbidity in Southwest Ethiopia: A prospective cross sectional study 11 Medical and Health Sciences 1103 Clinical Sciences. BMC Res Notes. 2018; 11 (679): 1-6.
[17] ReisWCT, Scopel CT, Correr CJ, Andrzejevski VMS. Analysis of clinical pharmacist interventions in a tertiary teaching hospital in Brazil Análise das intervenções de farmacêuticos clínicos em um hospital de ensino terciário do Brasil. Einstein. 2013; 11 (2): 190-196.
[18] Hussein M, Lenjisa JL, Woldu MA, Tegegne GT, Umeta GT, Dins H, et al. Assessme nt of drug related problems among hypertensive patients on follow up in Adama Hospital Medical College, East Ethiopia. Clin Pharmacol Bio-pharm. 2014; 3 (2): 2-7.
[19] Tigabu B, Daba D, Habte B. Drug-related problems among medical ward patients in Jimma University specialized hospital, Southwest Ethiopia. J Res Pharm Pract. 2014; 3 (1): 1-5.
[20] Urbina O, Ferrández O, luque S, grau S et al. Patient risk factors for developing a drug-related problem in a cardiology ward Therapeutics and Clinical Risk Mana gement 2015: 11 9–15.
[21] Mahammedsied W, Feyissa M, Shibeshi W. Assessment of Drug Therapy Problems and Contributing Factors among Adult Ambulatory Hypertensive Patients in Ayder Referral Hospital, Mekelle Northern Ethiopia. J Pharma Care Health Sys JPCHS, Vol. 7 Iss. 4 No: 218.
[22] Gizaw K. Drug Related Problems and Contributing Factors Among Adult Ambula tory Patients with Cardiovascular Diseases at Gebretsadik Shawo General Hospital, Bonga, South west Ethiopia. Journal of Natural Sciences Research www. iiste. orgISSN 2224-3186 (Paper) ISSN 2225-0921 (Online) Vol. 7, No. 1, 2017.
[23] Temesgen G Tegegne, Yimam B, Ali E Yesuf, Kefale B Gelaw et al. Drug Therapy Problem among Patients with Cardiovascular Diseases in Felege Hiwot Referral Hosp ital, North East, Ethiopia. International Journal of Pharmacy Teaching & Practices 201 4, Vol. 5, Issue 3, 989-996.
[24] Legesse Y Niriayo, Kumela K, Dessale T Kass, Tarekegn M Angamo. Drug therapy problems and contributing factors in the management of heart failure patients in Jimma University Specialized Hospital, Southwest-Ethiopia. |https://doi.org/10.1371/journal.pone.0206120 October 23, 2018.
[25] Peterson C. Characterization of drug-related problems and associated factors at a clinical pharmacy-naive hospital in the northern part of Sweden. Clinical pharmacy at Lycksele hospital. 2018.
Cite This Article
  • APA Style

    Gudisa Bereda, Gemechis Bereda. (2021). Characterization of Medication Related Problems Among Patients with Cardiovascular Disease in Medical Ward of Mettu Karl Referral Hospital, South Western, Ethiopia: A Prospective Observational Study. International Journal of Cardiovascular and Thoracic Surgery, 7(3), 34-40. https://doi.org/10.11648/j.ijcts.20210703.11

    Copy | Download

    ACS Style

    Gudisa Bereda; Gemechis Bereda. Characterization of Medication Related Problems Among Patients with Cardiovascular Disease in Medical Ward of Mettu Karl Referral Hospital, South Western, Ethiopia: A Prospective Observational Study. Int. J. Cardiovasc. Thorac. Surg. 2021, 7(3), 34-40. doi: 10.11648/j.ijcts.20210703.11

    Copy | Download

    AMA Style

    Gudisa Bereda, Gemechis Bereda. Characterization of Medication Related Problems Among Patients with Cardiovascular Disease in Medical Ward of Mettu Karl Referral Hospital, South Western, Ethiopia: A Prospective Observational Study. Int J Cardiovasc Thorac Surg. 2021;7(3):34-40. doi: 10.11648/j.ijcts.20210703.11

    Copy | Download

  • @article{10.11648/j.ijcts.20210703.11,
      author = {Gudisa Bereda and Gemechis Bereda},
      title = {Characterization of Medication Related Problems Among Patients with Cardiovascular Disease in Medical Ward of Mettu Karl Referral Hospital, South Western, Ethiopia: A Prospective Observational Study},
      journal = {International Journal of Cardiovascular and Thoracic Surgery},
      volume = {7},
      number = {3},
      pages = {34-40},
      doi = {10.11648/j.ijcts.20210703.11},
      url = {https://doi.org/10.11648/j.ijcts.20210703.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcts.20210703.11},
      abstract = {Background: Medication related problem is defined as: ‘an event or circumstance involving drug therapy that actually or potentially interferes with desired health outcomes. Drug related problems are of a major concern in health care because of increased cost, morbidity and mortality. cardiovascular diseases are a group of disorders of the heart and blood vessels. Objective: To discover characterization of medication related problems and contributing factors among cardiovascular patients in the medical ward of Mettu Karl Referral Hospital. Methods: A facility based prospective observational study design was carried from April 07 /2021 to June 09/2021. Data was collected through employing check list and semi-structured questioner. Data was entered and descriptive statistical analysis was done using statistical packages for social sciences 25.0 version statistical software. Both bi-variable and multivariable analysis performed to determine the association between outcome and predictors variables. A p-value of less than 0.05 was considered significant. Results: The overall rate of medication related problems among cardiovascular patients in medical ward was 53 (58.2%). The patient’s age group was in line of 36-59 years 49 (53.8%). Unnecessary drug therapy 15 (28.3%) were the mostly identified type of drug therapy problem followed by dosage too high 11 (20.8%). ACEIs 229 (17.1%) was commonly prescribed medication and potassium sparing 19 (2.2%) was least prescribed drugs. Age ≥ 60 years (AOR: 2.76; 95%CI: 1.342-3.945; P=0.004), rural area residents (AOR: 2.76; 95%CI: 1.014-2.758; P=0.003), length of hospital stay >7 days (AO R: 4.75; 95%CI: 2.986-11.723; P=0.007), number of medication >5 (AOR: 3.632-17.893; 95%CI: 2.986-11.723; P=0.001) were associated factor significantly causes medication related problems. Conclusion and Recommendation: The prevalence of medication related problems amid cardiovascular patients in medical ward was high. Less than half of patients were found to have co-morbidities and were had have social substance users. Hospitals and ministry of Health should have to establish pharmaceutical care services for better patient care.},
     year = {2021}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Characterization of Medication Related Problems Among Patients with Cardiovascular Disease in Medical Ward of Mettu Karl Referral Hospital, South Western, Ethiopia: A Prospective Observational Study
    AU  - Gudisa Bereda
    AU  - Gemechis Bereda
    Y1  - 2021/08/04
    PY  - 2021
    N1  - https://doi.org/10.11648/j.ijcts.20210703.11
    DO  - 10.11648/j.ijcts.20210703.11
    T2  - International Journal of Cardiovascular and Thoracic Surgery
    JF  - International Journal of Cardiovascular and Thoracic Surgery
    JO  - International Journal of Cardiovascular and Thoracic Surgery
    SP  - 34
    EP  - 40
    PB  - Science Publishing Group
    SN  - 2575-4882
    UR  - https://doi.org/10.11648/j.ijcts.20210703.11
    AB  - Background: Medication related problem is defined as: ‘an event or circumstance involving drug therapy that actually or potentially interferes with desired health outcomes. Drug related problems are of a major concern in health care because of increased cost, morbidity and mortality. cardiovascular diseases are a group of disorders of the heart and blood vessels. Objective: To discover characterization of medication related problems and contributing factors among cardiovascular patients in the medical ward of Mettu Karl Referral Hospital. Methods: A facility based prospective observational study design was carried from April 07 /2021 to June 09/2021. Data was collected through employing check list and semi-structured questioner. Data was entered and descriptive statistical analysis was done using statistical packages for social sciences 25.0 version statistical software. Both bi-variable and multivariable analysis performed to determine the association between outcome and predictors variables. A p-value of less than 0.05 was considered significant. Results: The overall rate of medication related problems among cardiovascular patients in medical ward was 53 (58.2%). The patient’s age group was in line of 36-59 years 49 (53.8%). Unnecessary drug therapy 15 (28.3%) were the mostly identified type of drug therapy problem followed by dosage too high 11 (20.8%). ACEIs 229 (17.1%) was commonly prescribed medication and potassium sparing 19 (2.2%) was least prescribed drugs. Age ≥ 60 years (AOR: 2.76; 95%CI: 1.342-3.945; P=0.004), rural area residents (AOR: 2.76; 95%CI: 1.014-2.758; P=0.003), length of hospital stay >7 days (AO R: 4.75; 95%CI: 2.986-11.723; P=0.007), number of medication >5 (AOR: 3.632-17.893; 95%CI: 2.986-11.723; P=0.001) were associated factor significantly causes medication related problems. Conclusion and Recommendation: The prevalence of medication related problems amid cardiovascular patients in medical ward was high. Less than half of patients were found to have co-morbidities and were had have social substance users. Hospitals and ministry of Health should have to establish pharmaceutical care services for better patient care.
    VL  - 7
    IS  - 3
    ER  - 

    Copy | Download

Author Information
  • SWAN Diagnostic Pharmaceutical Importer, Addis Ababa, Ethiopia

  • Awash Bank, Addis Ababa, Ethiopia

  • Sections