Synthesis, Characterization and Bacterial Growth Inhibitory Properties of Schiff-Base Ligands Derived from Amino Acids

James Tembei Titah; Coulibaly Wacothon Karime; Kevin Chambers; Anita Balogh; Kevin Joannou

doi:doi:10.11648/j.sjc.20200801.11

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Synthesis, Characterization and Bacterial Growth Inhibitory Properties of Schiff-Base Ligands Derived from Amino Acids

James Tembei Titah, Coulibaly Wacothon Karime, Kevin Chambers, Anita Balogh, Kevin Joannou

Published in Science Journal of Chemistry (Volume 8, Issue 1)

Received: 23 January 2020 Accepted: 13 February 2020 Published: 2 March 2020

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Abstract

Schiff-base ligands and their metal complexes are attracting a lot of research in bioinorganic and medicinal chemistry owing to their improved activity in biological systems. Six schiff-base ligands derived from amino acids; N-Salicylidene Alanine, N-Salicylidene Serine, N-Benzalidene Histidine, N-Balzalidene Leucine, N-4-(dimethylamino) benzalidene Phenylalanine, and N-4-(dimethylamino)benzalidene Valine have been synthesized, characterized and their bacterial growth inhibitory properties determined against Staphylococcus aureus and Escherichia coli. These schiff-bases are synthesized by the condensation reaction between carbonyl compounds (aldehydes and ketones) and amines (amino acids). Characterization of the schiff-base ligands is done using melting/decomposition temperatures, FTIR spectroscopy, US-visible spectroscopy, and solubility. It is observed that, all the schiff-base ligands contain the imine or azomethine (C=N) group with a stretching frequency ranging from 2200 - 2400 cm^-1. In addition, all the schiff-base ligands are seen to be soluble in water, which is paramount in their application in biological systems. The structures of the schiff-base ligands were deduced based on the characterization techniques. Furthermore, the bacterial growth inhibitory properties of the schiff-base ligands were done using the Agar Well Diffusion method. The results reveal that, all the schiff-base ligands show no toxicity effect or negative bacterial growth properties against gram positive (Staphylococcus aureus) and gram negative (Escherichia coli) bacteria.

Published in	Science Journal of Chemistry (Volume 8, Issue 1)
DOI	10.11648/j.sjc.20200801.11
Page(s)	1-6
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Amino Acids, Characterization, Schiff-Bases, Synthesis, Biological Activities, Imine Group

References

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[6]	T. Mangamamba, M. C. Ganorkar, and G. Swarnabala, International Journal of Inorganic Chemistry, 2014, pp 1-22.
[7]	Emad Yousif et al., Arabian Journal of Chemistry, 2017, (10), pp S1639-S1644.
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[12]	Chohan Z. H., Arif M., Akhtar M. A., Supuran C. T., Bioinorganic Chemistry and Application, 2006, pp 1-13.
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[17]	G. L. Miessler, P. J. Fisher, and D. A. Tarr, Inorganic Chemistry, 2013, 5th Edition.

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APA Style

James Tembei Titah, Coulibaly Wacothon Karime, Kevin Chambers, Anita Balogh, Kevin Joannou. (2020). Synthesis, Characterization and Bacterial Growth Inhibitory Properties of Schiff-Base Ligands Derived from Amino Acids. Science Journal of Chemistry, 8(1), 1-6. https://doi.org/10.11648/j.sjc.20200801.11

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ACS Style

James Tembei Titah; Coulibaly Wacothon Karime; Kevin Chambers; Anita Balogh; Kevin Joannou. Synthesis, Characterization and Bacterial Growth Inhibitory Properties of Schiff-Base Ligands Derived from Amino Acids. Sci. J. Chem. 2020, 8(1), 1-6. doi: 10.11648/j.sjc.20200801.11

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AMA Style

James Tembei Titah, Coulibaly Wacothon Karime, Kevin Chambers, Anita Balogh, Kevin Joannou. Synthesis, Characterization and Bacterial Growth Inhibitory Properties of Schiff-Base Ligands Derived from Amino Acids. Sci J Chem. 2020;8(1):1-6. doi: 10.11648/j.sjc.20200801.11

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@article{10.11648/j.sjc.20200801.11,
  author = {James Tembei Titah and Coulibaly Wacothon Karime and Kevin Chambers and Anita Balogh and Kevin Joannou},
  title = {Synthesis, Characterization and Bacterial Growth Inhibitory Properties of Schiff-Base Ligands Derived from Amino Acids},
  journal = {Science Journal of Chemistry},
  volume = {8},
  number = {1},
  pages = {1-6},
  doi = {10.11648/j.sjc.20200801.11},
  url = {https://doi.org/10.11648/j.sjc.20200801.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjc.20200801.11},
  abstract = {Schiff-base ligands and their metal complexes are attracting a lot of research in bioinorganic and medicinal chemistry owing to their improved activity in biological systems. Six schiff-base ligands derived from amino acids; N-Salicylidene Alanine, N-Salicylidene Serine, N-Benzalidene Histidine, N-Balzalidene Leucine, N-4-(dimethylamino) benzalidene Phenylalanine, and N-4-(dimethylamino)benzalidene Valine have been synthesized, characterized and their bacterial growth inhibitory properties determined against Staphylococcus aureus and Escherichia coli. These schiff-bases are synthesized by the condensation reaction between carbonyl compounds (aldehydes and ketones) and amines (amino acids). Characterization of the schiff-base ligands is done using melting/decomposition temperatures, FTIR spectroscopy, US-visible spectroscopy, and solubility. It is observed that, all the schiff-base ligands contain the imine or azomethine (C=N) group with a stretching frequency ranging from 2200 - 2400 cm-1. In addition, all the schiff-base ligands are seen to be soluble in water, which is paramount in their application in biological systems. The structures of the schiff-base ligands were deduced based on the characterization techniques. Furthermore, the bacterial growth inhibitory properties of the schiff-base ligands were done using the Agar Well Diffusion method. The results reveal that, all the schiff-base ligands show no toxicity effect or negative bacterial growth properties against gram positive (Staphylococcus aureus) and gram negative (Escherichia coli) bacteria.},
 year = {2020}
}

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TY  - JOUR
T1  - Synthesis, Characterization and Bacterial Growth Inhibitory Properties of Schiff-Base Ligands Derived from Amino Acids
AU  - James Tembei Titah
AU  - Coulibaly Wacothon Karime
AU  - Kevin Chambers
AU  - Anita Balogh
AU  - Kevin Joannou
Y1  - 2020/03/02
PY  - 2020
N1  - https://doi.org/10.11648/j.sjc.20200801.11
DO  - 10.11648/j.sjc.20200801.11
T2  - Science Journal of Chemistry
JF  - Science Journal of Chemistry
JO  - Science Journal of Chemistry
SP  - 1
EP  - 6
PB  - Science Publishing Group
SN  - 2330-099X
UR  - https://doi.org/10.11648/j.sjc.20200801.11
AB  - Schiff-base ligands and their metal complexes are attracting a lot of research in bioinorganic and medicinal chemistry owing to their improved activity in biological systems. Six schiff-base ligands derived from amino acids; N-Salicylidene Alanine, N-Salicylidene Serine, N-Benzalidene Histidine, N-Balzalidene Leucine, N-4-(dimethylamino) benzalidene Phenylalanine, and N-4-(dimethylamino)benzalidene Valine have been synthesized, characterized and their bacterial growth inhibitory properties determined against Staphylococcus aureus and Escherichia coli. These schiff-bases are synthesized by the condensation reaction between carbonyl compounds (aldehydes and ketones) and amines (amino acids). Characterization of the schiff-base ligands is done using melting/decomposition temperatures, FTIR spectroscopy, US-visible spectroscopy, and solubility. It is observed that, all the schiff-base ligands contain the imine or azomethine (C=N) group with a stretching frequency ranging from 2200 - 2400 cm-1. In addition, all the schiff-base ligands are seen to be soluble in water, which is paramount in their application in biological systems. The structures of the schiff-base ligands were deduced based on the characterization techniques. Furthermore, the bacterial growth inhibitory properties of the schiff-base ligands were done using the Agar Well Diffusion method. The results reveal that, all the schiff-base ligands show no toxicity effect or negative bacterial growth properties against gram positive (Staphylococcus aureus) and gram negative (Escherichia coli) bacteria.
VL  - 8
IS  - 1
ER  -

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Author Information

James Tembei Titah

Department of Mathematical and Physical Sciences, Concordia University of Edmonton, Chemistry Research Laboratory, Edmonton, Canada
Coulibaly Wacothon Karime

Department of Chemistry and Biochemistry, Peleforo Gon Coulibaly University, Korhogo, Ivory Coast
Kevin Chambers

Department of Mathematical and Physical Sciences, Concordia University of Edmonton, Chemistry Research Laboratory, Edmonton, Canada
Anita Balogh

Department of Mathematical and Physical Sciences, Concordia University of Edmonton, Chemistry Research Laboratory, Edmonton, Canada
Kevin Joannou

Department of Mathematical and Physical Sciences, Concordia University of Edmonton, Chemistry Research Laboratory, Edmonton, Canada

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APA Style

James Tembei Titah, Coulibaly Wacothon Karime, Kevin Chambers, Anita Balogh, Kevin Joannou. (2020). Synthesis, Characterization and Bacterial Growth Inhibitory Properties of Schiff-Base Ligands Derived from Amino Acids. Science Journal of Chemistry, 8(1), 1-6. https://doi.org/10.11648/j.sjc.20200801.11

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ACS Style

James Tembei Titah; Coulibaly Wacothon Karime; Kevin Chambers; Anita Balogh; Kevin Joannou. Synthesis, Characterization and Bacterial Growth Inhibitory Properties of Schiff-Base Ligands Derived from Amino Acids. Sci. J. Chem. 2020, 8(1), 1-6. doi: 10.11648/j.sjc.20200801.11

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AMA Style

James Tembei Titah, Coulibaly Wacothon Karime, Kevin Chambers, Anita Balogh, Kevin Joannou. Synthesis, Characterization and Bacterial Growth Inhibitory Properties of Schiff-Base Ligands Derived from Amino Acids. Sci J Chem. 2020;8(1):1-6. doi: 10.11648/j.sjc.20200801.11

Copy | Download

@article{10.11648/j.sjc.20200801.11,
  author = {James Tembei Titah and Coulibaly Wacothon Karime and Kevin Chambers and Anita Balogh and Kevin Joannou},
  title = {Synthesis, Characterization and Bacterial Growth Inhibitory Properties of Schiff-Base Ligands Derived from Amino Acids},
  journal = {Science Journal of Chemistry},
  volume = {8},
  number = {1},
  pages = {1-6},
  doi = {10.11648/j.sjc.20200801.11},
  url = {https://doi.org/10.11648/j.sjc.20200801.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjc.20200801.11},
  abstract = {Schiff-base ligands and their metal complexes are attracting a lot of research in bioinorganic and medicinal chemistry owing to their improved activity in biological systems. Six schiff-base ligands derived from amino acids; N-Salicylidene Alanine, N-Salicylidene Serine, N-Benzalidene Histidine, N-Balzalidene Leucine, N-4-(dimethylamino) benzalidene Phenylalanine, and N-4-(dimethylamino)benzalidene Valine have been synthesized, characterized and their bacterial growth inhibitory properties determined against Staphylococcus aureus and Escherichia coli. These schiff-bases are synthesized by the condensation reaction between carbonyl compounds (aldehydes and ketones) and amines (amino acids). Characterization of the schiff-base ligands is done using melting/decomposition temperatures, FTIR spectroscopy, US-visible spectroscopy, and solubility. It is observed that, all the schiff-base ligands contain the imine or azomethine (C=N) group with a stretching frequency ranging from 2200 - 2400 cm-1. In addition, all the schiff-base ligands are seen to be soluble in water, which is paramount in their application in biological systems. The structures of the schiff-base ligands were deduced based on the characterization techniques. Furthermore, the bacterial growth inhibitory properties of the schiff-base ligands were done using the Agar Well Diffusion method. The results reveal that, all the schiff-base ligands show no toxicity effect or negative bacterial growth properties against gram positive (Staphylococcus aureus) and gram negative (Escherichia coli) bacteria.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - Synthesis, Characterization and Bacterial Growth Inhibitory Properties of Schiff-Base Ligands Derived from Amino Acids
AU  - James Tembei Titah
AU  - Coulibaly Wacothon Karime
AU  - Kevin Chambers
AU  - Anita Balogh
AU  - Kevin Joannou
Y1  - 2020/03/02
PY  - 2020
N1  - https://doi.org/10.11648/j.sjc.20200801.11
DO  - 10.11648/j.sjc.20200801.11
T2  - Science Journal of Chemistry
JF  - Science Journal of Chemistry
JO  - Science Journal of Chemistry
SP  - 1
EP  - 6
PB  - Science Publishing Group
SN  - 2330-099X
UR  - https://doi.org/10.11648/j.sjc.20200801.11
AB  - Schiff-base ligands and their metal complexes are attracting a lot of research in bioinorganic and medicinal chemistry owing to their improved activity in biological systems. Six schiff-base ligands derived from amino acids; N-Salicylidene Alanine, N-Salicylidene Serine, N-Benzalidene Histidine, N-Balzalidene Leucine, N-4-(dimethylamino) benzalidene Phenylalanine, and N-4-(dimethylamino)benzalidene Valine have been synthesized, characterized and their bacterial growth inhibitory properties determined against Staphylococcus aureus and Escherichia coli. These schiff-bases are synthesized by the condensation reaction between carbonyl compounds (aldehydes and ketones) and amines (amino acids). Characterization of the schiff-base ligands is done using melting/decomposition temperatures, FTIR spectroscopy, US-visible spectroscopy, and solubility. It is observed that, all the schiff-base ligands contain the imine or azomethine (C=N) group with a stretching frequency ranging from 2200 - 2400 cm-1. In addition, all the schiff-base ligands are seen to be soluble in water, which is paramount in their application in biological systems. The structures of the schiff-base ligands were deduced based on the characterization techniques. Furthermore, the bacterial growth inhibitory properties of the schiff-base ligands were done using the Agar Well Diffusion method. The results reveal that, all the schiff-base ligands show no toxicity effect or negative bacterial growth properties against gram positive (Staphylococcus aureus) and gram negative (Escherichia coli) bacteria.
VL  - 8
IS  - 1
ER  -

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