Journal of Plant Sciences

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Highly Anticancer and Moderate Thrombolytic Property of Accacia rugata of Mimosaceae Family

Received: Feb. 02, 2020    Accepted: Feb. 26, 2020    Published: Apr. 07, 2020
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Abstract

Medicinal plants containing potent bioactive compound effective in treating many diseases exert different pharmacological action. This study designed to evaluate the cytotoxic and thrombolytic activity of Acacia rugata of Mimosaceae family. The cytotoxic and thrombolytic activity was evaluated by brine-shrimp lethality bioassay and in-vitro clot lysis method. Methanol, petroleum-ether, n-hexane, chloroform and dichloromethane fraction leaves (MEL, PETFL, n-HxFL, CHFL, DCMFL), methanol and n-hexane fraction of fruits (MEF, n-HxFF) and methanol fraction of bark (MEB) were used to evaluate cytotoxicity of the plant. Each extracts showed significant cytotoxic property. The LC50 values of MEL, PETFL, n-HxFL, CHFL, DCMFL, MEF, n-HxFF, MEB were observed 1.436, 0.039, 0.974, 0.626, 0.121, 0.176, 0.865, 0.081 µg/ml when compared to standard vincristine (positive control) which LC50 value was 0.049 µg/ml. In thrombolytic activity evaluation 20 mg/ml, 10 mg/ml, 5 mg/ml and 2.5 mg/ml dose of MEL showed 40.52 ± 2.91, 35.09 ± 2.71, 31.96 ± 2.02 and 24.91 ± 3.05% clot lysis respectively while 0.9% NaCl solution (negative control) and standard streptokinase (positive control) exhibited 7.41 ± 1.73% and 48.91 ± 3.52% of clot lysis. It can be assumed that different solvent extracts of A. rugata have important cytotoxic and thrombolytic activity as compared to standard compounds.

DOI 10.11648/j.jps.20200801.12
Published in Journal of Plant Sciences ( Volume 8, Issue 1, February 2020 )
Page(s) 12-16
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Cytotoxic, Thrombolytic, Streptokinase, Vincristine, % of Clot Lysis, Acacia rugata

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Cite This Article
  • APA Style

    Bibi Humayra Khanam, Ahmed Rakib, Farhana Binta Faiz, Md. Giash Uddin, Mohammed Kamrul Hossain, et al. (2020). Highly Anticancer and Moderate Thrombolytic Property of Accacia rugata of Mimosaceae Family. Journal of Plant Sciences, 8(1), 12-16. https://doi.org/10.11648/j.jps.20200801.12

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    ACS Style

    Bibi Humayra Khanam; Ahmed Rakib; Farhana Binta Faiz; Md. Giash Uddin; Mohammed Kamrul Hossain, et al. Highly Anticancer and Moderate Thrombolytic Property of Accacia rugata of Mimosaceae Family. J. Plant Sci. 2020, 8(1), 12-16. doi: 10.11648/j.jps.20200801.12

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    AMA Style

    Bibi Humayra Khanam, Ahmed Rakib, Farhana Binta Faiz, Md. Giash Uddin, Mohammed Kamrul Hossain, et al. Highly Anticancer and Moderate Thrombolytic Property of Accacia rugata of Mimosaceae Family. J Plant Sci. 2020;8(1):12-16. doi: 10.11648/j.jps.20200801.12

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  • @article{10.11648/j.jps.20200801.12,
      author = {Bibi Humayra Khanam and Ahmed Rakib and Farhana Binta Faiz and Md. Giash Uddin and Mohammed Kamrul Hossain and Ramiz Ahmed Sultan},
      title = {Highly Anticancer and Moderate Thrombolytic Property of Accacia rugata of Mimosaceae Family},
      journal = {Journal of Plant Sciences},
      volume = {8},
      number = {1},
      pages = {12-16},
      doi = {10.11648/j.jps.20200801.12},
      url = {https://doi.org/10.11648/j.jps.20200801.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.jps.20200801.12},
      abstract = {Medicinal plants containing potent bioactive compound effective in treating many diseases exert different pharmacological action. This study designed to evaluate the cytotoxic and thrombolytic activity of Acacia rugata of Mimosaceae family. The cytotoxic and thrombolytic activity was evaluated by brine-shrimp lethality bioassay and in-vitro clot lysis method. Methanol, petroleum-ether, n-hexane, chloroform and dichloromethane fraction leaves (MEL, PETFL, n-HxFL, CHFL, DCMFL), methanol and n-hexane fraction of fruits (MEF, n-HxFF) and methanol fraction of bark (MEB) were used to evaluate cytotoxicity of the plant. Each extracts showed significant cytotoxic property. The LC50 values of MEL, PETFL, n-HxFL, CHFL, DCMFL, MEF, n-HxFF, MEB were observed 1.436, 0.039, 0.974, 0.626, 0.121, 0.176, 0.865, 0.081 µg/ml when compared to standard vincristine (positive control) which LC50 value was 0.049 µg/ml. In thrombolytic activity evaluation 20 mg/ml, 10 mg/ml, 5 mg/ml and 2.5 mg/ml dose of MEL showed 40.52 ± 2.91, 35.09 ± 2.71, 31.96 ± 2.02 and 24.91 ± 3.05% clot lysis respectively while 0.9% NaCl solution (negative control) and standard streptokinase (positive control) exhibited 7.41 ± 1.73% and 48.91 ± 3.52% of clot lysis. It can be assumed that different solvent extracts of A. rugata have important cytotoxic and thrombolytic activity as compared to standard compounds.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Highly Anticancer and Moderate Thrombolytic Property of Accacia rugata of Mimosaceae Family
    AU  - Bibi Humayra Khanam
    AU  - Ahmed Rakib
    AU  - Farhana Binta Faiz
    AU  - Md. Giash Uddin
    AU  - Mohammed Kamrul Hossain
    AU  - Ramiz Ahmed Sultan
    Y1  - 2020/04/07
    PY  - 2020
    N1  - https://doi.org/10.11648/j.jps.20200801.12
    DO  - 10.11648/j.jps.20200801.12
    T2  - Journal of Plant Sciences
    JF  - Journal of Plant Sciences
    JO  - Journal of Plant Sciences
    SP  - 12
    EP  - 16
    PB  - Science Publishing Group
    SN  - 2331-0731
    UR  - https://doi.org/10.11648/j.jps.20200801.12
    AB  - Medicinal plants containing potent bioactive compound effective in treating many diseases exert different pharmacological action. This study designed to evaluate the cytotoxic and thrombolytic activity of Acacia rugata of Mimosaceae family. The cytotoxic and thrombolytic activity was evaluated by brine-shrimp lethality bioassay and in-vitro clot lysis method. Methanol, petroleum-ether, n-hexane, chloroform and dichloromethane fraction leaves (MEL, PETFL, n-HxFL, CHFL, DCMFL), methanol and n-hexane fraction of fruits (MEF, n-HxFF) and methanol fraction of bark (MEB) were used to evaluate cytotoxicity of the plant. Each extracts showed significant cytotoxic property. The LC50 values of MEL, PETFL, n-HxFL, CHFL, DCMFL, MEF, n-HxFF, MEB were observed 1.436, 0.039, 0.974, 0.626, 0.121, 0.176, 0.865, 0.081 µg/ml when compared to standard vincristine (positive control) which LC50 value was 0.049 µg/ml. In thrombolytic activity evaluation 20 mg/ml, 10 mg/ml, 5 mg/ml and 2.5 mg/ml dose of MEL showed 40.52 ± 2.91, 35.09 ± 2.71, 31.96 ± 2.02 and 24.91 ± 3.05% clot lysis respectively while 0.9% NaCl solution (negative control) and standard streptokinase (positive control) exhibited 7.41 ± 1.73% and 48.91 ± 3.52% of clot lysis. It can be assumed that different solvent extracts of A. rugata have important cytotoxic and thrombolytic activity as compared to standard compounds.
    VL  - 8
    IS  - 1
    ER  - 

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Author Information
  • Department of Pharmacy, University of Chittagong, Chittagong, Bangladesh

  • Department of Pharmacy, University of Chittagong, Chittagong, Bangladesh

  • Department of Pharmacy, University of Chittagong, Chittagong, Bangladesh

  • Department of Pharmacy, University of Chittagong, Chittagong, Bangladesh

  • Department of Pharmacy, University of Chittagong, Chittagong, Bangladesh

  • Department of Pharmacy, University of Chittagong, Chittagong, Bangladesh

  • Section