International Journal of Biomedical Materials Research

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Chitosan/ Alginate /Gellan Gum Hybrid Hydrogel as a Vehicle for Controlled Release of Drug

Received: Jan. 16, 2019    Accepted: Feb. 20, 2019    Published: Mar. 06, 2019
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Abstract

Hybrid hydrogel was fabricated by a classic sol-gel method using EDC/NHS as crosslink reagent grafting onto the thermoplastic polyurethane (TPU), nonwoven fabric, for controlled release of drug. In this study, precursor acetic acid (AA) was used to plasma deposit on the surface of TPU to form a hydrophilic thin film. Hybrid hydrogel was investigated through scanning electron microscopy (SEM), water contact angle (WCA) measurement, Fourier transform infra-red (FTIR) spectroscopy, UV/V is spectroscopy, equilibrium swelling ratio, MTT assay and drug delivery system studies. This polyelectrolyte complexes (PECs) formed hydrogel, pH-sensitive type, was evaluated at pH value of 1.2 and 7.4 of buffer solution and at temperature of 37C to observe its rate of swelling and drug release features with caffeine. Moreover, the mechanism of caffeine release from membrane devices (n=0.58) are anomalous transport, non-Fickian diffusion, the value of n lies between 0.43 and 0.85. It has an excellent release ratio up to about 90% absorption cumulative amounts of caffeine at pH 7.4 after 8h and could be a beneficial carrier for fragile drugs.

DOI 10.11648/j.ijbmr.20190701.13
Published in International Journal of Biomedical Materials Research ( Volume 7, Issue 1, June 2019 )
Page(s) 16-23
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

TPU, Acetic Acid Plasma, EDC/NHS Grafting, Hybrid Hydrogel

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  • APA Style

    Jiunn-An Pan, Hsuan-Liang Liu, Ko-Shao Chen. (2019). Chitosan/ Alginate /Gellan Gum Hybrid Hydrogel as a Vehicle for Controlled Release of Drug. International Journal of Biomedical Materials Research, 7(1), 16-23. https://doi.org/10.11648/j.ijbmr.20190701.13

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    ACS Style

    Jiunn-An Pan; Hsuan-Liang Liu; Ko-Shao Chen. Chitosan/ Alginate /Gellan Gum Hybrid Hydrogel as a Vehicle for Controlled Release of Drug. Int. J. Biomed. Mater. Res. 2019, 7(1), 16-23. doi: 10.11648/j.ijbmr.20190701.13

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    AMA Style

    Jiunn-An Pan, Hsuan-Liang Liu, Ko-Shao Chen. Chitosan/ Alginate /Gellan Gum Hybrid Hydrogel as a Vehicle for Controlled Release of Drug. Int J Biomed Mater Res. 2019;7(1):16-23. doi: 10.11648/j.ijbmr.20190701.13

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  • @article{10.11648/j.ijbmr.20190701.13,
      author = {Jiunn-An Pan and Hsuan-Liang Liu and Ko-Shao Chen},
      title = {Chitosan/ Alginate /Gellan Gum Hybrid Hydrogel as a Vehicle for Controlled Release of Drug},
      journal = {International Journal of Biomedical Materials Research},
      volume = {7},
      number = {1},
      pages = {16-23},
      doi = {10.11648/j.ijbmr.20190701.13},
      url = {https://doi.org/10.11648/j.ijbmr.20190701.13},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ijbmr.20190701.13},
      abstract = {Hybrid hydrogel was fabricated by a classic sol-gel method using EDC/NHS as crosslink reagent grafting onto the thermoplastic polyurethane (TPU), nonwoven fabric, for controlled release of drug. In this study, precursor acetic acid (AA) was used to plasma deposit on the surface of TPU to form a hydrophilic thin film. Hybrid hydrogel was investigated through scanning electron microscopy (SEM), water contact angle (WCA) measurement, Fourier transform infra-red (FTIR) spectroscopy, UV/V is spectroscopy, equilibrium swelling ratio, MTT assay and drug delivery system studies. This polyelectrolyte complexes (PECs) formed hydrogel, pH-sensitive type, was evaluated at pH value of 1.2 and 7.4 of buffer solution and at temperature of 37C to observe its rate of swelling and drug release features with caffeine. Moreover, the mechanism of caffeine release from membrane devices (n=0.58) are anomalous transport, non-Fickian diffusion, the value of n lies between 0.43 and 0.85. It has an excellent release ratio up to about 90% absorption cumulative amounts of caffeine at pH 7.4 after 8h and could be a beneficial carrier for fragile drugs.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Chitosan/ Alginate /Gellan Gum Hybrid Hydrogel as a Vehicle for Controlled Release of Drug
    AU  - Jiunn-An Pan
    AU  - Hsuan-Liang Liu
    AU  - Ko-Shao Chen
    Y1  - 2019/03/06
    PY  - 2019
    N1  - https://doi.org/10.11648/j.ijbmr.20190701.13
    DO  - 10.11648/j.ijbmr.20190701.13
    T2  - International Journal of Biomedical Materials Research
    JF  - International Journal of Biomedical Materials Research
    JO  - International Journal of Biomedical Materials Research
    SP  - 16
    EP  - 23
    PB  - Science Publishing Group
    SN  - 2330-7579
    UR  - https://doi.org/10.11648/j.ijbmr.20190701.13
    AB  - Hybrid hydrogel was fabricated by a classic sol-gel method using EDC/NHS as crosslink reagent grafting onto the thermoplastic polyurethane (TPU), nonwoven fabric, for controlled release of drug. In this study, precursor acetic acid (AA) was used to plasma deposit on the surface of TPU to form a hydrophilic thin film. Hybrid hydrogel was investigated through scanning electron microscopy (SEM), water contact angle (WCA) measurement, Fourier transform infra-red (FTIR) spectroscopy, UV/V is spectroscopy, equilibrium swelling ratio, MTT assay and drug delivery system studies. This polyelectrolyte complexes (PECs) formed hydrogel, pH-sensitive type, was evaluated at pH value of 1.2 and 7.4 of buffer solution and at temperature of 37C to observe its rate of swelling and drug release features with caffeine. Moreover, the mechanism of caffeine release from membrane devices (n=0.58) are anomalous transport, non-Fickian diffusion, the value of n lies between 0.43 and 0.85. It has an excellent release ratio up to about 90% absorption cumulative amounts of caffeine at pH 7.4 after 8h and could be a beneficial carrier for fragile drugs.
    VL  - 7
    IS  - 1
    ER  - 

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Author Information
  • Graduate Institution Engineering Technology-Doctoral, National Taipei University of Technology, Taipei, Taiwan; New Taipei Municipal Yonghe Junior High School, New Taipei City, Taiwan

  • Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, Taiwan

  • Department of Materials Engineering, Tatung University, Taipei, Taiwan

  • Section