Ro-autoantibody System and Characterisation of Protein Isoforms of Ro60 in Systemic Erythematosus Lupus (An Update)

Manideep Chowdary Pachva

doi:doi:10.11648/j.jcebe.20200401.11

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Ro-autoantibody System and Characterisation of Protein Isoforms of Ro60 in Systemic Erythematosus Lupus (An Update)

Manideep Chowdary Pachva

Published in Journal of Chemical, Environmental and Biological Engineering (Volume 4, Issue 1)

Received: 3 February 2020 Accepted: 24 February 2020 Published: 11 May 2020

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Abstract

Systemic lupus erythematosus (SLE) is a multisystem inflammatory and autoimmune disorder that usually affects various self-tissues of the body, whose sera is predominantly reported to have autoantibodies against Ro60 or TROVE-2 protein. Ro60 is a ring-shaped RNA-binding protein, that usually binds misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs (hY-RNAs). Y RNAs are known to be involved in regulating cellular stress responses and also in initiation of chromosomal replication. Ro60 is known to have 6 isoforms along with the short isoform. Recent studies of Ro60 protein in mammalian cells suggests that Ro60 is vital for the cell survival after the UV irradiation. It is evident that Ro60 is essential for degrading the damaged RNA due to the UV irradiation, because exposure to the UV irradiation might result in RNA: RNA and RNA: Protein crosslinks. Also, role of Ro60 in maintaining the tolerance is supported by the experiment which resulted in development of lupus like syndrome in the Ro60 knock-down mice by producing antibodies against chromatin and ribosomes. Thus, it is evident from the various studies that Ro60 is inevitably important for the cells and tissues for preventing the autoimmunity. This review focusses on the pathology and autoantibody system in SLE, structure and functions of the Ro60 in association with Y RNAs, and epitope bindings of Ro60 to the anti-Ro positive sera from SLE patients.

Published in	Journal of Chemical, Environmental and Biological Engineering (Volume 4, Issue 1)
DOI	10.11648/j.jcebe.20200401.11
Page(s)	1-10
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Self-tolerance, Systemic Lupus Erythematosus, Ro60 Protein, Y RNAs, Anti-Ro Autoantibodies

References

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Manideep Chowdary Pachva. (2020). Ro-autoantibody System and Characterisation of Protein Isoforms of Ro60 in Systemic Erythematosus Lupus (An Update). Journal of Chemical, Environmental and Biological Engineering, 4(1), 1-10. https://doi.org/10.11648/j.jcebe.20200401.11

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Manideep Chowdary Pachva. Ro-autoantibody System and Characterisation of Protein Isoforms of Ro60 in Systemic Erythematosus Lupus (An Update). J. Chem. Environ. Biol. Eng. 2020, 4(1), 1-10. doi: 10.11648/j.jcebe.20200401.11

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AMA Style

Manideep Chowdary Pachva. Ro-autoantibody System and Characterisation of Protein Isoforms of Ro60 in Systemic Erythematosus Lupus (An Update). J Chem Environ Biol Eng. 2020;4(1):1-10. doi: 10.11648/j.jcebe.20200401.11

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@article{10.11648/j.jcebe.20200401.11,
  author = {Manideep Chowdary Pachva},
  title = {Ro-autoantibody System and Characterisation of Protein Isoforms of Ro60 in Systemic Erythematosus Lupus (An Update)},
  journal = {Journal of Chemical, Environmental and Biological Engineering},
  volume = {4},
  number = {1},
  pages = {1-10},
  doi = {10.11648/j.jcebe.20200401.11},
  url = {https://doi.org/10.11648/j.jcebe.20200401.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jcebe.20200401.11},
  abstract = {Systemic lupus erythematosus (SLE) is a multisystem inflammatory and autoimmune disorder that usually affects various self-tissues of the body, whose sera is predominantly reported to have autoantibodies against Ro60 or TROVE-2 protein. Ro60 is a ring-shaped RNA-binding protein, that usually binds misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs (hY-RNAs). Y RNAs are known to be involved in regulating cellular stress responses and also in initiation of chromosomal replication. Ro60 is known to have 6 isoforms along with the short isoform. Recent studies of Ro60 protein in mammalian cells suggests that Ro60 is vital for the cell survival after the UV irradiation. It is evident that Ro60 is essential for degrading the damaged RNA due to the UV irradiation, because exposure to the UV irradiation might result in RNA: RNA and RNA: Protein crosslinks. Also, role of Ro60 in maintaining the tolerance is supported by the experiment which resulted in development of lupus like syndrome in the Ro60 knock-down mice by producing antibodies against chromatin and ribosomes. Thus, it is evident from the various studies that Ro60 is inevitably important for the cells and tissues for preventing the autoimmunity. This review focusses on the pathology and autoantibody system in SLE, structure and functions of the Ro60 in association with Y RNAs, and epitope bindings of Ro60 to the anti-Ro positive sera from SLE patients.},
 year = {2020}
}

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TY  - JOUR
T1  - Ro-autoantibody System and Characterisation of Protein Isoforms of Ro60 in Systemic Erythematosus Lupus (An Update)
AU  - Manideep Chowdary Pachva
Y1  - 2020/05/11
PY  - 2020
N1  - https://doi.org/10.11648/j.jcebe.20200401.11
DO  - 10.11648/j.jcebe.20200401.11
T2  - Journal of Chemical, Environmental and Biological Engineering
JF  - Journal of Chemical, Environmental and Biological Engineering
JO  - Journal of Chemical, Environmental and Biological Engineering
SP  - 1
EP  - 10
PB  - Science Publishing Group
SN  - 2640-267X
UR  - https://doi.org/10.11648/j.jcebe.20200401.11
AB  - Systemic lupus erythematosus (SLE) is a multisystem inflammatory and autoimmune disorder that usually affects various self-tissues of the body, whose sera is predominantly reported to have autoantibodies against Ro60 or TROVE-2 protein. Ro60 is a ring-shaped RNA-binding protein, that usually binds misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs (hY-RNAs). Y RNAs are known to be involved in regulating cellular stress responses and also in initiation of chromosomal replication. Ro60 is known to have 6 isoforms along with the short isoform. Recent studies of Ro60 protein in mammalian cells suggests that Ro60 is vital for the cell survival after the UV irradiation. It is evident that Ro60 is essential for degrading the damaged RNA due to the UV irradiation, because exposure to the UV irradiation might result in RNA: RNA and RNA: Protein crosslinks. Also, role of Ro60 in maintaining the tolerance is supported by the experiment which resulted in development of lupus like syndrome in the Ro60 knock-down mice by producing antibodies against chromatin and ribosomes. Thus, it is evident from the various studies that Ro60 is inevitably important for the cells and tissues for preventing the autoimmunity. This review focusses on the pathology and autoantibody system in SLE, structure and functions of the Ro60 in association with Y RNAs, and epitope bindings of Ro60 to the anti-Ro positive sera from SLE patients.
VL  - 4
IS  - 1
ER  -

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Manideep Chowdary Pachva

Department of Molecular Genetics, Bangor University, Bangor, United Kingdom

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APA Style

Manideep Chowdary Pachva. (2020). Ro-autoantibody System and Characterisation of Protein Isoforms of Ro60 in Systemic Erythematosus Lupus (An Update). Journal of Chemical, Environmental and Biological Engineering, 4(1), 1-10. https://doi.org/10.11648/j.jcebe.20200401.11

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ACS Style

Manideep Chowdary Pachva. Ro-autoantibody System and Characterisation of Protein Isoforms of Ro60 in Systemic Erythematosus Lupus (An Update). J. Chem. Environ. Biol. Eng. 2020, 4(1), 1-10. doi: 10.11648/j.jcebe.20200401.11

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AMA Style

Manideep Chowdary Pachva. Ro-autoantibody System and Characterisation of Protein Isoforms of Ro60 in Systemic Erythematosus Lupus (An Update). J Chem Environ Biol Eng. 2020;4(1):1-10. doi: 10.11648/j.jcebe.20200401.11

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@article{10.11648/j.jcebe.20200401.11,
  author = {Manideep Chowdary Pachva},
  title = {Ro-autoantibody System and Characterisation of Protein Isoforms of Ro60 in Systemic Erythematosus Lupus (An Update)},
  journal = {Journal of Chemical, Environmental and Biological Engineering},
  volume = {4},
  number = {1},
  pages = {1-10},
  doi = {10.11648/j.jcebe.20200401.11},
  url = {https://doi.org/10.11648/j.jcebe.20200401.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jcebe.20200401.11},
  abstract = {Systemic lupus erythematosus (SLE) is a multisystem inflammatory and autoimmune disorder that usually affects various self-tissues of the body, whose sera is predominantly reported to have autoantibodies against Ro60 or TROVE-2 protein. Ro60 is a ring-shaped RNA-binding protein, that usually binds misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs (hY-RNAs). Y RNAs are known to be involved in regulating cellular stress responses and also in initiation of chromosomal replication. Ro60 is known to have 6 isoforms along with the short isoform. Recent studies of Ro60 protein in mammalian cells suggests that Ro60 is vital for the cell survival after the UV irradiation. It is evident that Ro60 is essential for degrading the damaged RNA due to the UV irradiation, because exposure to the UV irradiation might result in RNA: RNA and RNA: Protein crosslinks. Also, role of Ro60 in maintaining the tolerance is supported by the experiment which resulted in development of lupus like syndrome in the Ro60 knock-down mice by producing antibodies against chromatin and ribosomes. Thus, it is evident from the various studies that Ro60 is inevitably important for the cells and tissues for preventing the autoimmunity. This review focusses on the pathology and autoantibody system in SLE, structure and functions of the Ro60 in association with Y RNAs, and epitope bindings of Ro60 to the anti-Ro positive sera from SLE patients.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - Ro-autoantibody System and Characterisation of Protein Isoforms of Ro60 in Systemic Erythematosus Lupus (An Update)
AU  - Manideep Chowdary Pachva
Y1  - 2020/05/11
PY  - 2020
N1  - https://doi.org/10.11648/j.jcebe.20200401.11
DO  - 10.11648/j.jcebe.20200401.11
T2  - Journal of Chemical, Environmental and Biological Engineering
JF  - Journal of Chemical, Environmental and Biological Engineering
JO  - Journal of Chemical, Environmental and Biological Engineering
SP  - 1
EP  - 10
PB  - Science Publishing Group
SN  - 2640-267X
UR  - https://doi.org/10.11648/j.jcebe.20200401.11
AB  - Systemic lupus erythematosus (SLE) is a multisystem inflammatory and autoimmune disorder that usually affects various self-tissues of the body, whose sera is predominantly reported to have autoantibodies against Ro60 or TROVE-2 protein. Ro60 is a ring-shaped RNA-binding protein, that usually binds misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs (hY-RNAs). Y RNAs are known to be involved in regulating cellular stress responses and also in initiation of chromosomal replication. Ro60 is known to have 6 isoforms along with the short isoform. Recent studies of Ro60 protein in mammalian cells suggests that Ro60 is vital for the cell survival after the UV irradiation. It is evident that Ro60 is essential for degrading the damaged RNA due to the UV irradiation, because exposure to the UV irradiation might result in RNA: RNA and RNA: Protein crosslinks. Also, role of Ro60 in maintaining the tolerance is supported by the experiment which resulted in development of lupus like syndrome in the Ro60 knock-down mice by producing antibodies against chromatin and ribosomes. Thus, it is evident from the various studies that Ro60 is inevitably important for the cells and tissues for preventing the autoimmunity. This review focusses on the pathology and autoantibody system in SLE, structure and functions of the Ro60 in association with Y RNAs, and epitope bindings of Ro60 to the anti-Ro positive sera from SLE patients.
VL  - 4
IS  - 1
ER  -

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