Study of Biodegradation of Film Materials with D-Cycloserine Based on Polyurethaneurea and the Dynamics of Drug Release

Tetiana Rudenchyk; Rita Rozhnova; Nataliia Galatenko; Lіudmyla Nechaeva

doi:doi:10.11648/j.ajpst.20190504.11

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Study of Biodegradation of Film Materials with D-Cycloserine Based on Polyurethaneurea and the Dynamics of Drug Release

Tetiana Rudenchyk, Rita Rozhnova, Nataliia Galatenko, Lіudmyla Nechaeva

Received: 1 October 2019 Accepted: 26 October 2019 Published: 8 November 2019

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Abstract

The study of the ability to biodegradation of film materials with D-cycloserine obtained on the basis of polyurethaneurea with fragments of the copolymer of N-vinylpyrrolidone with vinyl acetate and vinyl alcohol, and 1.6-hexamethylenediamine in the structure under the influence of biological medium 199 for 1, 3 and 6 months were conducted. IR spectroscopy and physical-mechanical tests of these film materials before and after incubation in biological medium 199 were investigated. According to research results, there are decrease of the tensile strength (in 1.29-2.50 times) and a relative elongation at break (in 1.15-1.91 times) after incubation in biological medium 199. It is established that under the influence of biological medium 199 there are processes of biodegradation of film materials. The introduction of D-cycloserine into the composition of polyurethaneurea contributes to their biodegradation. It allows us to conclude that biodegradation is due to release of D-cycloserine. The study of the dynamics of D-cycloserine release from the polymer matrix was conducted by spectrophotometric method. The amount of drug varies depending on the copolymer content in structure of film materials (75.00-96.71% of the total amount of the introduced drug). It has been established that the studied film materials are capable to the prolonged release of D-cycloserine. It allows using them as film coatings for medicine with different ability to release of drug depending on requirements.

DOI	10.11648/j.ajpst.20190504.11
Published in	American Journal of Polymer Science and Technology (Volume 5, Issue 4, December 2019)
Page(s)	97-104
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Polyurethaneurea, D-Cycloserine, N-vinylpyrrolidone Copolymer, Model Biological Medium 199, Biodegradation

References

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APA Style

Tetiana Rudenchyk, Rita Rozhnova, Nataliia Galatenko, Lіudmyla Nechaeva. (2019). Study of Biodegradation of Film Materials with D-Cycloserine Based on Polyurethaneurea and the Dynamics of Drug Release. American Journal of Polymer Science and Technology, 5(4), 97-104. https://doi.org/10.11648/j.ajpst.20190504.11

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ACS Style

Tetiana Rudenchyk; Rita Rozhnova; Nataliia Galatenko; Lіudmyla Nechaeva. Study of Biodegradation of Film Materials with D-Cycloserine Based on Polyurethaneurea and the Dynamics of Drug Release. Am. J. Polym. Sci. Technol. 2019, 5(4), 97-104. doi: 10.11648/j.ajpst.20190504.11

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AMA Style

Tetiana Rudenchyk, Rita Rozhnova, Nataliia Galatenko, Lіudmyla Nechaeva. Study of Biodegradation of Film Materials with D-Cycloserine Based on Polyurethaneurea and the Dynamics of Drug Release. Am J Polym Sci Technol. 2019;5(4):97-104. doi: 10.11648/j.ajpst.20190504.11

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@article{10.11648/j.ajpst.20190504.11,
  author = {Tetiana Rudenchyk and Rita Rozhnova and Nataliia Galatenko and Lіudmyla Nechaeva},
  title = {Study of Biodegradation of Film Materials with D-Cycloserine Based on Polyurethaneurea and the Dynamics of Drug Release},
  journal = {American Journal of Polymer Science and Technology},
  volume = {5},
  number = {4},
  pages = {97-104},
  doi = {10.11648/j.ajpst.20190504.11},
  url = {https://doi.org/10.11648/j.ajpst.20190504.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpst.20190504.11},
  abstract = {The study of the ability to biodegradation of film materials with D-cycloserine obtained on the basis of polyurethaneurea with fragments of the copolymer of N-vinylpyrrolidone with vinyl acetate and vinyl alcohol, and 1.6-hexamethylenediamine in the structure under the influence of biological medium 199 for 1, 3 and 6 months were conducted. IR spectroscopy and physical-mechanical tests of these film materials before and after incubation in biological medium 199 were investigated. According to research results, there are decrease of the tensile strength (in 1.29-2.50 times) and a relative elongation at break (in 1.15-1.91 times) after incubation in biological medium 199. It is established that under the influence of biological medium 199 there are processes of biodegradation of film materials. The introduction of D-cycloserine into the composition of polyurethaneurea contributes to their biodegradation. It allows us to conclude that biodegradation is due to release of D-cycloserine. The study of the dynamics of D-cycloserine release from the polymer matrix was conducted by spectrophotometric method. The amount of drug varies depending on the copolymer content in structure of film materials (75.00-96.71% of the total amount of the introduced drug). It has been established that the studied film materials are capable to the prolonged release of D-cycloserine. It allows using them as film coatings for medicine with different ability to release of drug depending on requirements.},
 year = {2019}
}

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TY  - JOUR
T1  - Study of Biodegradation of Film Materials with D-Cycloserine Based on Polyurethaneurea and the Dynamics of Drug Release
AU  - Tetiana Rudenchyk
AU  - Rita Rozhnova
AU  - Nataliia Galatenko
AU  - Lіudmyla Nechaeva
Y1  - 2019/11/08
PY  - 2019
N1  - https://doi.org/10.11648/j.ajpst.20190504.11
DO  - 10.11648/j.ajpst.20190504.11
T2  - American Journal of Polymer Science and Technology
JF  - American Journal of Polymer Science and Technology
JO  - American Journal of Polymer Science and Technology
SP  - 97
EP  - 104
PB  - Science Publishing Group
SN  - 2575-5986
UR  - https://doi.org/10.11648/j.ajpst.20190504.11
AB  - The study of the ability to biodegradation of film materials with D-cycloserine obtained on the basis of polyurethaneurea with fragments of the copolymer of N-vinylpyrrolidone with vinyl acetate and vinyl alcohol, and 1.6-hexamethylenediamine in the structure under the influence of biological medium 199 for 1, 3 and 6 months were conducted. IR spectroscopy and physical-mechanical tests of these film materials before and after incubation in biological medium 199 were investigated. According to research results, there are decrease of the tensile strength (in 1.29-2.50 times) and a relative elongation at break (in 1.15-1.91 times) after incubation in biological medium 199. It is established that under the influence of biological medium 199 there are processes of biodegradation of film materials. The introduction of D-cycloserine into the composition of polyurethaneurea contributes to their biodegradation. It allows us to conclude that biodegradation is due to release of D-cycloserine. The study of the dynamics of D-cycloserine release from the polymer matrix was conducted by spectrophotometric method. The amount of drug varies depending on the copolymer content in structure of film materials (75.00-96.71% of the total amount of the introduced drug). It has been established that the studied film materials are capable to the prolonged release of D-cycloserine. It allows using them as film coatings for medicine with different ability to release of drug depending on requirements.
VL  - 5
IS  - 4
ER  -

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Author Information

Tetiana Rudenchyk

Department of Polymers of Medical Appointment, Institute of Macromolecular Chemistry of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
Rita Rozhnova

Department of Polymers of Medical Appointment, Institute of Macromolecular Chemistry of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
Nataliia Galatenko

Department of Polymers of Medical Appointment, Institute of Macromolecular Chemistry of the National Academy of Sciences of Ukraine, Kyiv, Ukraine
Lіudmyla Nechaeva

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APA Style

Tetiana Rudenchyk, Rita Rozhnova, Nataliia Galatenko, Lіudmyla Nechaeva. (2019). Study of Biodegradation of Film Materials with D-Cycloserine Based on Polyurethaneurea and the Dynamics of Drug Release. American Journal of Polymer Science and Technology, 5(4), 97-104. https://doi.org/10.11648/j.ajpst.20190504.11

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ACS Style

Tetiana Rudenchyk; Rita Rozhnova; Nataliia Galatenko; Lіudmyla Nechaeva. Study of Biodegradation of Film Materials with D-Cycloserine Based on Polyurethaneurea and the Dynamics of Drug Release. Am. J. Polym. Sci. Technol. 2019, 5(4), 97-104. doi: 10.11648/j.ajpst.20190504.11

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AMA Style

Tetiana Rudenchyk, Rita Rozhnova, Nataliia Galatenko, Lіudmyla Nechaeva. Study of Biodegradation of Film Materials with D-Cycloserine Based on Polyurethaneurea and the Dynamics of Drug Release. Am J Polym Sci Technol. 2019;5(4):97-104. doi: 10.11648/j.ajpst.20190504.11

Copy | Download

@article{10.11648/j.ajpst.20190504.11,
  author = {Tetiana Rudenchyk and Rita Rozhnova and Nataliia Galatenko and Lіudmyla Nechaeva},
  title = {Study of Biodegradation of Film Materials with D-Cycloserine Based on Polyurethaneurea and the Dynamics of Drug Release},
  journal = {American Journal of Polymer Science and Technology},
  volume = {5},
  number = {4},
  pages = {97-104},
  doi = {10.11648/j.ajpst.20190504.11},
  url = {https://doi.org/10.11648/j.ajpst.20190504.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpst.20190504.11},
  abstract = {The study of the ability to biodegradation of film materials with D-cycloserine obtained on the basis of polyurethaneurea with fragments of the copolymer of N-vinylpyrrolidone with vinyl acetate and vinyl alcohol, and 1.6-hexamethylenediamine in the structure under the influence of biological medium 199 for 1, 3 and 6 months were conducted. IR spectroscopy and physical-mechanical tests of these film materials before and after incubation in biological medium 199 were investigated. According to research results, there are decrease of the tensile strength (in 1.29-2.50 times) and a relative elongation at break (in 1.15-1.91 times) after incubation in biological medium 199. It is established that under the influence of biological medium 199 there are processes of biodegradation of film materials. The introduction of D-cycloserine into the composition of polyurethaneurea contributes to their biodegradation. It allows us to conclude that biodegradation is due to release of D-cycloserine. The study of the dynamics of D-cycloserine release from the polymer matrix was conducted by spectrophotometric method. The amount of drug varies depending on the copolymer content in structure of film materials (75.00-96.71% of the total amount of the introduced drug). It has been established that the studied film materials are capable to the prolonged release of D-cycloserine. It allows using them as film coatings for medicine with different ability to release of drug depending on requirements.},
 year = {2019}
}

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TY  - JOUR
T1  - Study of Biodegradation of Film Materials with D-Cycloserine Based on Polyurethaneurea and the Dynamics of Drug Release
AU  - Tetiana Rudenchyk
AU  - Rita Rozhnova
AU  - Nataliia Galatenko
AU  - Lіudmyla Nechaeva
Y1  - 2019/11/08
PY  - 2019
N1  - https://doi.org/10.11648/j.ajpst.20190504.11
DO  - 10.11648/j.ajpst.20190504.11
T2  - American Journal of Polymer Science and Technology
JF  - American Journal of Polymer Science and Technology
JO  - American Journal of Polymer Science and Technology
SP  - 97
EP  - 104
PB  - Science Publishing Group
SN  - 2575-5986
UR  - https://doi.org/10.11648/j.ajpst.20190504.11
AB  - The study of the ability to biodegradation of film materials with D-cycloserine obtained on the basis of polyurethaneurea with fragments of the copolymer of N-vinylpyrrolidone with vinyl acetate and vinyl alcohol, and 1.6-hexamethylenediamine in the structure under the influence of biological medium 199 for 1, 3 and 6 months were conducted. IR spectroscopy and physical-mechanical tests of these film materials before and after incubation in biological medium 199 were investigated. According to research results, there are decrease of the tensile strength (in 1.29-2.50 times) and a relative elongation at break (in 1.15-1.91 times) after incubation in biological medium 199. It is established that under the influence of biological medium 199 there are processes of biodegradation of film materials. The introduction of D-cycloserine into the composition of polyurethaneurea contributes to their biodegradation. It allows us to conclude that biodegradation is due to release of D-cycloserine. The study of the dynamics of D-cycloserine release from the polymer matrix was conducted by spectrophotometric method. The amount of drug varies depending on the copolymer content in structure of film materials (75.00-96.71% of the total amount of the introduced drug). It has been established that the studied film materials are capable to the prolonged release of D-cycloserine. It allows using them as film coatings for medicine with different ability to release of drug depending on requirements.
VL  - 5
IS  - 4
ER  -

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