International Journal of Clinical and Experimental Medical Sciences

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Complications of Deep Brain Stimulation in the Treatment of Parkinson’s Disease

Received: Aug. 14, 2019    Accepted: Sep. 10, 2019    Published: Sep. 26, 2019
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Abstract

Objectives: To study the therapeutic effect and complications of deep brain stimulation (DBS) to Parkinson’s disease (PD). Patients and Methods: A retrospective analysis of DBS performed on 44 patients with Parkinson’s disease who had complications in the post-operation. Results: 1). A stimulation effect was observed in all PD patients during the operation, with the most obvious effect being relief of muscular tension, followed by improvement in tremor and bradykinesia. 2). The implantable pulse generator was activated from 3 days to 1 month after the implantation of the stimulation electrode, and then had an obvious effect. 3). Clinical follow-up was performed from 3 months to 2.5 years post-implantation. The symptoms assessed using the UPDRS score were significantly improved. 4). Two cases of cerebral hemorrhage and vesicular effusion were related to surgical methods. There were several cases of pneumonia in the postoperative fever and two cases of urinary system infection. One case of traverse fracture also occurred. Postoperative electrode exposure and local infection occurred in 1 case. There were 3 cases of lethargy, 2 cases of hallucinations. In the postoperative period, intelligence decreased further in 1 case. One patient had no obvious improvement in rigidity. 5). One case had difficulties in eye opening within 1 month. One case of PD had poor rigidity control. There was also decrease memory after stimulation in 2 cases. Conclusion: Proper selection of patients, appropriate DBS surgical methods and reasonable adjustment of stimulation parameters can effectively prevent and treat related complications.

DOI 10.11648/j.ijcems.20190504.12
Published in International Journal of Clinical and Experimental Medical Sciences ( Volume 5, Issue 4, July 2019 )
Page(s) 58-61
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

DBS, PD, Complications, Surgery

References
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[2] Mehta SH and Sethi KD. Bilateral deep brain stimulation versus best medical therapy for patients with advanced Parkinson’s disease. Jama 2009; 9: 63-73.
[3] Bermudez C, Rodriguez W, Huo Y, et al:. Towards Machine Learning Prediction of Deep Brain Stimulation (DBS) Intra-operative Efficacy Maps. 2018.
[4] Pauls KAM, Hammesfahr S, Moro E, et al:. Deep brain stimulation in the ventrolateral thalamus/subthalamic area in dystonia with head tremor. Movement Disorders 2014; 29: 953-959.
[5] Buhmann C, Moll CKE, Zittel S, et al:. Deep Brain Stimulation of the Ventrolateral Thalamic Base and Posterior Subthalamic Area in Dystonic Head Tremor. Acta Neurochir Suppl 2013; 117: 67-72.
[6] Majdinasab F, Khatoonabadi A, Khoddami SM, et al:. The effect of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on the acoustic and prosodic features in patients with Parkinson's disease: A study protocol for the first trial on Iranian patients. Medical journal of the Islamic Republic of Iran 2017; 31: 786-791.
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[16] Morishita T, Hilliard JD, Okun MS, et al:. Postoperative lead migration in deep brain stimulation surgery: Incidence, risk factors, and clinical impact. Plos One 2017; 12: e0183711.
[17] Odekerken VJ, Van LT, Staal MJ, et al:. Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson's disease (NSTAPS study): a randomised controlled trial. Lancet Neurology 2013; 12: 37-44.
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    Hui Huang, Liyuan Xie, Min Chen, Ming Guo, Xingen Zhu, et al. (2019). Complications of Deep Brain Stimulation in the Treatment of Parkinson’s Disease. International Journal of Clinical and Experimental Medical Sciences, 5(4), 58-61. https://doi.org/10.11648/j.ijcems.20190504.12

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    ACS Style

    Hui Huang; Liyuan Xie; Min Chen; Ming Guo; Xingen Zhu, et al. Complications of Deep Brain Stimulation in the Treatment of Parkinson’s Disease. Int. J. Clin. Exp. Med. Sci. 2019, 5(4), 58-61. doi: 10.11648/j.ijcems.20190504.12

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    AMA Style

    Hui Huang, Liyuan Xie, Min Chen, Ming Guo, Xingen Zhu, et al. Complications of Deep Brain Stimulation in the Treatment of Parkinson’s Disease. Int J Clin Exp Med Sci. 2019;5(4):58-61. doi: 10.11648/j.ijcems.20190504.12

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  • @article{10.11648/j.ijcems.20190504.12,
      author = {Hui Huang and Liyuan Xie and Min Chen and Ming Guo and Xingen Zhu and Suyue Zheng and Mingwei Lu},
      title = {Complications of Deep Brain Stimulation in the Treatment of Parkinson’s Disease},
      journal = {International Journal of Clinical and Experimental Medical Sciences},
      volume = {5},
      number = {4},
      pages = {58-61},
      doi = {10.11648/j.ijcems.20190504.12},
      url = {https://doi.org/10.11648/j.ijcems.20190504.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ijcems.20190504.12},
      abstract = {Objectives: To study the therapeutic effect and complications of deep brain stimulation (DBS) to Parkinson’s disease (PD). Patients and Methods: A retrospective analysis of DBS performed on 44 patients with Parkinson’s disease who had complications in the post-operation. Results: 1). A stimulation effect was observed in all PD patients during the operation, with the most obvious effect being relief of muscular tension, followed by improvement in tremor and bradykinesia. 2). The implantable pulse generator was activated from 3 days to 1 month after the implantation of the stimulation electrode, and then had an obvious effect. 3). Clinical follow-up was performed from 3 months to 2.5 years post-implantation. The symptoms assessed using the UPDRS score were significantly improved. 4). Two cases of cerebral hemorrhage and vesicular effusion were related to surgical methods. There were several cases of pneumonia in the postoperative fever and two cases of urinary system infection. One case of traverse fracture also occurred. Postoperative electrode exposure and local infection occurred in 1 case. There were 3 cases of lethargy, 2 cases of hallucinations. In the postoperative period, intelligence decreased further in 1 case. One patient had no obvious improvement in rigidity. 5). One case had difficulties in eye opening within 1 month. One case of PD had poor rigidity control. There was also decrease memory after stimulation in 2 cases. Conclusion: Proper selection of patients, appropriate DBS surgical methods and reasonable adjustment of stimulation parameters can effectively prevent and treat related complications.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Complications of Deep Brain Stimulation in the Treatment of Parkinson’s Disease
    AU  - Hui Huang
    AU  - Liyuan Xie
    AU  - Min Chen
    AU  - Ming Guo
    AU  - Xingen Zhu
    AU  - Suyue Zheng
    AU  - Mingwei Lu
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    DO  - 10.11648/j.ijcems.20190504.12
    T2  - International Journal of Clinical and Experimental Medical Sciences
    JF  - International Journal of Clinical and Experimental Medical Sciences
    JO  - International Journal of Clinical and Experimental Medical Sciences
    SP  - 58
    EP  - 61
    PB  - Science Publishing Group
    SN  - 2469-8032
    UR  - https://doi.org/10.11648/j.ijcems.20190504.12
    AB  - Objectives: To study the therapeutic effect and complications of deep brain stimulation (DBS) to Parkinson’s disease (PD). Patients and Methods: A retrospective analysis of DBS performed on 44 patients with Parkinson’s disease who had complications in the post-operation. Results: 1). A stimulation effect was observed in all PD patients during the operation, with the most obvious effect being relief of muscular tension, followed by improvement in tremor and bradykinesia. 2). The implantable pulse generator was activated from 3 days to 1 month after the implantation of the stimulation electrode, and then had an obvious effect. 3). Clinical follow-up was performed from 3 months to 2.5 years post-implantation. The symptoms assessed using the UPDRS score were significantly improved. 4). Two cases of cerebral hemorrhage and vesicular effusion were related to surgical methods. There were several cases of pneumonia in the postoperative fever and two cases of urinary system infection. One case of traverse fracture also occurred. Postoperative electrode exposure and local infection occurred in 1 case. There were 3 cases of lethargy, 2 cases of hallucinations. In the postoperative period, intelligence decreased further in 1 case. One patient had no obvious improvement in rigidity. 5). One case had difficulties in eye opening within 1 month. One case of PD had poor rigidity control. There was also decrease memory after stimulation in 2 cases. Conclusion: Proper selection of patients, appropriate DBS surgical methods and reasonable adjustment of stimulation parameters can effectively prevent and treat related complications.
    VL  - 5
    IS  - 4
    ER  - 

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Author Information
  • Department of Neurosurgery, Second Affiliation Hospital, Nanchang University, Nanchang, China

  • Department of Neurosurgery, Second Affiliation Hospital, Nanchang University, Nanchang, China

  • Department of Neurosurgery, Second Affiliation Hospital, Nanchang University, Nanchang, China

  • Psychosomatic Medicine, Second Affiliation Hospital, Nanchang University, Nanchang, China

  • Department of Neurosurgery, Second Affiliation Hospital, Nanchang University, Nanchang, China

  • Department of Neurosurgery, First Affiliation Hospital, Nanchang University, Nanchang, China

  • Department of Neurosurgery, Second Affiliation Hospital, Nanchang University, Nanchang, China

  • Section