International Journal of Clinical and Experimental Medical Sciences

| Peer-Reviewed |

Effects of Periconceptual Omega-3-Fatty Acid Supplementation on in Vitro Fertilization Success and Miscarriage Rates in Patients of a German Fertility Centre

Received: Sep. 06, 2019    Accepted: Sep. 27, 2019    Published: Oct. 10, 2019
Views:       Downloads:

Share This Article

Abstract

Long-chain omega-3 fatty acids have been positively related with improvement of fertility in both women and men. Primary natural source of omega-3- fatty acids is seafood. As this also can bei the source of toxicants like f.e. lead, mercury and cadmium, reproductive benefits may be counteracted. Therefore, our approach was to supplement pharmaceutical grade omega-3-fatty acids in order to assess potential benefits of omega-3-fatty acids on modulation of IVF-success by dietary measures in a well-defined group of patients of a German Fertility Centre. A group of 52 IVF-patients with a history of at least two miscarriages or unsuccessful in vitro fertilization approaches received periconceptual omega-3-fatty acid supplementation for a time period of at least 3 weeks. The “historical” control group, consisting of 1109 patients without omega-3-fatty acid supplementation, was generated out of the Fertility Centre´s patient database. The same inclusion criteria (history of at least two miscarriages or unsuccessful in vitro fertilization approaches) were applied for both groups. Omega-3-fatty acid supplementation lead to significantly enhanced in vitro fertilization success rates as well as to reduction of miscarriage rates compared to patients of the control group. The results encourage to design further age-matched, double-blinded prospective studies in order to verify a positive influence of dietary intervention and lifestyle modification on fertility rates.

DOI 10.11648/j.ijcems.20190505.11
Published in International Journal of Clinical and Experimental Medical Sciences ( Volume 5, Issue 5, September 2019 )
Page(s) 62-66
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Omega-3-Fatty Acid Supplementation, In Vitro Fertilization, Miscarriage Rates

References
[1] Burr, M. L., Fehily, A. M., Gilbert, J, F., Rogers S., Holliday R, M., Sweetnam P, M. et al. (1989) Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). Lancet, 2, 757-761.
[2] Marchioli, R., Barzi, F., Bomba, E., Chieffo, C., Di, G. D., Di, M. R. et al. (2002) Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI) -Prevenzione. Circulation, 105, 1897-1903.
[3] Freeman, M. P., Hibbeln, J. R., Wisner, K. L., Davis, J. M., Mischoulon, D., Peet, M. et al. (2006) Omega-3 fatty acids: evidence basis for treatment and future research in psychiatry. Journal of Clinical Psychiatry, 67, 1954-1967.
[4] Yan Y., Jiang W., Spinetti T., Tardivel A., Castillo R., Bourquin C. et al. (2013) Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Immunity, 38, 1154-1163.
[5] Chavarro, J. E., Stampfer, M. J., Li, H., Campos, H., Kurth, T., Ma, J. (2007) A prospective study of polyunsaturated fatty acid levels in blood and prostate cancer risk. Cancer Epidemiology, Biomarkers & Prevention, 16, 1364-1370.
[6] Honest, H., Forbes, C. A., Duree, K. H., Norman, G., Duffy, S. B., Tsourapas, A. et al. (2009) Screening to prevent spontaneous preterm birth: systematic reviews of accuracy and effectiveness literature with economic modelling. Health Technology Assessment, 13, 1-627.
[7] Nakao, J., Ohba, T., Takaishi, K., Katabuchi, H. (2015) Omega-3 fatty acids for the treatment of hypertriglyceridemia during the second trimester. Nutrition, 31, 409-412.
[8] Di Cintio, E., Parazzini, F., Chatenoud, L., Sourace, M., Benzi, G., Zanconato, G. et al. (2001) Dietary factors and risk of spontaneous abortion. European Journal of Obstetrics & Gynecology and Reproductive Biology, 95, 132-136.
[9] Salas-Hueto, A., Rosique-Esteban, N., Becerra-Tomás, N., Vizmanos, B., Bulló, M., Salas-Salvadó, J. (2018) The effecst of nutrients and dietary supplements on sperm quality parameters: a systematic review and meta-analysis of randomized clinical trials. Advances in Nutrition, 9, 833-848.
[10] Falsig, A. L., Gleerup, C. S., Knudsen, U. B. (2019) The influence of omega-3 fatty acids on semen quality markers: a systematic PRISMA review. Andrology, doi: 10.1111/andr.12649. [Epub ahead of print].
[11] Helland, I. B., Smith, L., Saarem, K., Saugstad, O. D., Drevon, C. A. (2003) Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children's IQ at 4 years of age. Pediatrics, 111, e39-e44.
[12] Jensen, C. L. (2006) Effects of n-3 fatty acids during pregnancy and lactation. The American Journal of Clinical Nutrition, 83, 1452S-1457S.
[13] Mmbaga, N., Luk, J. (2012) The impact of preconceptual diet on the outcome of reproductive treatments. Current Opinion in Obstetrics and Gynecology, 24, 127-131.
[14] Jungheim, E. S., Frolova, AI., Jiang, H., Riley, J. K. (2013) Relationship between serum polyunsaturated fatty acids and pregnancy in women undergoing in vitro fertilization. The Journal of Clinical Endocrinology and Metabolism, 98, E1364-E1368.
[15] Kermack, A. J., Calder, P. C., Houghton, F. D., Godfrey, K. M., Macklon, N. S. (2014) A randomised controlled trial of a periconceptional dietary intervention in women undergoing IVF treatment (PREPARE trial). BMC Women´s Health, 14, 130.
[16] Lass, A:, Belluzzi, A. (2019) Omega-3 polyunsaturated fatty acids and IVF treatment. Reproductive Biomedicine Online, 38, 95-99.
[17] Eskow, A. M., Wormer, K. C., Matthews, M. L., Norton, H. J., Papadakis, M. A., Hurst, B. S. (2017) The association between fatty acid index and in vitro fertilization outcomes. Journal of Assisted Reproduction and Genetics, 34, 1627-1632.
[18] Wise, L. A., Wesselink, A. K., Tucker, K. L., Saklani, S., Mikkelsenm E. M., Cueto, H., Riis, A. H. et al. (2017) Dietary fat intake and fecundability in 2 preconception cohort studies. American Journal of Epidemiology, 187, 60-74.
[19] Mumford, S. L., Browne, R. W., Kim, K., Nichols, C., Wilcox, B., Silver, R. M., Connell, M. T. et al. (2018) Preconception plasma phospholipid fatty acids and fecundability. The Journal of Clinical Endocrinology & Metabolism, 103, 4501-4510.
[20] Chiu, Y. H., Karmon, A. E., Gaskins, A. ., Arvizu, M., Williams, P. L., Souter, I., Rueda, B. R. et al. (2018) Serum omega-3 fatty acids and treatment outcomes among women undergoing assisted reproduction. Human Reproduction, 33, 156-161.
[21] Rahman, M. M., Gasparini, C., Turchini, G. M., Evans, J. P. (2014) Experimental reduction in dietary omega-3 polyunsaturated fatty acids depresses sperm competitiveness. Biology Letters, 10, 20140623.
[22] Nandi, S., Chattopadhyay, D. N., Verma, J. P., Sarkar, S. K., Mukhopadhyay, P. K. (2001) Effect of dietary supplementation of fatty acids and vitamins on the breeding performance of the carp Catla catla. Reproduction Nutrition Development, 41, 365-375.
[23] Ghaffarilaleh, V., Fouladi-Nashta, A., Paramio, M. T. (2014) Effect of alpha-linolenic acid on oocyte maturation and embryo development of prepubertal sheep oocytes. Theriogenology, 14, 82, 686-696.
[24] Moallem, U., Shafran, A., Zachut, M., Dekel, I., Portnick, Y., Arieli, A. (2013) Dietary alpha-linolenic acid from flaxseed oil improved folliculogenesis and IVF performance in dairy cows, similar to eicosapentaenoic and docosahexaenoic acids from fish oil. Reproduction, 146, 603-614.
[25] Lee, S. A., Whenham, N., Bedford, M. R. (2019) Review on docosahexaenoic acid in poutry and swine nutrition: consequences of enriched animal products on performance and health characteristics. Animal Nutrition, 5, 11-21.
[26] Salas-Huetos, A., James. E. R., Aston, K. I., Jenkins, T. G., Carrell D. T. (2019) Diet and sperm quality: nutrients, foods and dietary patterns. Reproductive Biology, doi: 10.1016/j.repbio.2019.07.005. [Epub ahead of print].
[27] Yao, D., Mills, J. N. (2016) Male infertility: lifestyle factors and holistic, complementary, and alternative therapies. Asian Journal of Andrology, 18, 410-418.
[28] Minguez-Alarcón, L., Chavarro, J. E., Mendiola, J., Roca, M., Tanrikut, C., Vioque, J., Jorgensend N. et al. (2017) Fatty acid intake in relation to reproductive hormones and testicular volumen among young healthy men. Asian Journal of Andrology, 19, 184-190.
[29] Lazzarin, N., Vaquero, E., Exacoustos, C., Bertonotti, E., Romanini, M. E., Arduini, D. (2009) Low-dose aspirin and omega-3 fatty acids improve uterine artery blood flow velocity in women with recurrent miscarriage due to impaired uterine perfusion. Fertility and Sterility, 92, 296-300.
[30] Rossi, E., Costa, M. (1993) Fish oil derivatives as a prophylaxis of recurrent miscarriage associated with antiphospholipid antibodies (APL): a pilot study. Lupus, 2, 319-323.
[31] Glenville, M. Nutritional supplements in pregnancy: commercial push or evidence based? (2006) Current Opinion in Obstetrics and Gynecology, 18, 642-647.
[32] Ambrose, D. J., Kastelic, J. P., Corbett, R., Pitney, P. A., Petit, H. V., Small, J. A. et al. (2006) Lower pregnancy losses in lactating dairy cows fed a diet enriched in alpha-linolenic acid. Journal of Dairy Science, 89, 3066-3074.
Cite This Article
  • APA Style

    Arasch Bareksei, Gerd Hafner, Sebastian Pfeiffer, Kathrin Schlatterer. (2019). Effects of Periconceptual Omega-3-Fatty Acid Supplementation on in Vitro Fertilization Success and Miscarriage Rates in Patients of a German Fertility Centre. International Journal of Clinical and Experimental Medical Sciences, 5(5), 62-66. https://doi.org/10.11648/j.ijcems.20190505.11

    Copy | Download

    ACS Style

    Arasch Bareksei; Gerd Hafner; Sebastian Pfeiffer; Kathrin Schlatterer. Effects of Periconceptual Omega-3-Fatty Acid Supplementation on in Vitro Fertilization Success and Miscarriage Rates in Patients of a German Fertility Centre. Int. J. Clin. Exp. Med. Sci. 2019, 5(5), 62-66. doi: 10.11648/j.ijcems.20190505.11

    Copy | Download

    AMA Style

    Arasch Bareksei, Gerd Hafner, Sebastian Pfeiffer, Kathrin Schlatterer. Effects of Periconceptual Omega-3-Fatty Acid Supplementation on in Vitro Fertilization Success and Miscarriage Rates in Patients of a German Fertility Centre. Int J Clin Exp Med Sci. 2019;5(5):62-66. doi: 10.11648/j.ijcems.20190505.11

    Copy | Download

  • @article{10.11648/j.ijcems.20190505.11,
      author = {Arasch Bareksei and Gerd Hafner and Sebastian Pfeiffer and Kathrin Schlatterer},
      title = {Effects of Periconceptual Omega-3-Fatty Acid Supplementation on in Vitro Fertilization Success and Miscarriage Rates in Patients of a German Fertility Centre},
      journal = {International Journal of Clinical and Experimental Medical Sciences},
      volume = {5},
      number = {5},
      pages = {62-66},
      doi = {10.11648/j.ijcems.20190505.11},
      url = {https://doi.org/10.11648/j.ijcems.20190505.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ijcems.20190505.11},
      abstract = {Long-chain omega-3 fatty acids have been positively related with improvement of fertility in both women and men. Primary natural source of omega-3- fatty acids is seafood. As this also can bei the source of toxicants like f.e. lead, mercury and cadmium, reproductive benefits may be counteracted. Therefore, our approach was to supplement pharmaceutical grade omega-3-fatty acids in order to assess potential benefits of omega-3-fatty acids on modulation of IVF-success by dietary measures in a well-defined group of patients of a German Fertility Centre. A group of 52 IVF-patients with a history of at least two miscarriages or unsuccessful in vitro fertilization approaches received periconceptual omega-3-fatty acid supplementation for a time period of at least 3 weeks. The “historical” control group, consisting of 1109 patients without omega-3-fatty acid supplementation, was generated out of the Fertility Centre´s patient database. The same inclusion criteria (history of at least two miscarriages or unsuccessful in vitro fertilization approaches) were applied for both groups. Omega-3-fatty acid supplementation lead to significantly enhanced in vitro fertilization success rates as well as to reduction of miscarriage rates compared to patients of the control group. The results encourage to design further age-matched, double-blinded prospective studies in order to verify a positive influence of dietary intervention and lifestyle modification on fertility rates.},
     year = {2019}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Effects of Periconceptual Omega-3-Fatty Acid Supplementation on in Vitro Fertilization Success and Miscarriage Rates in Patients of a German Fertility Centre
    AU  - Arasch Bareksei
    AU  - Gerd Hafner
    AU  - Sebastian Pfeiffer
    AU  - Kathrin Schlatterer
    Y1  - 2019/10/10
    PY  - 2019
    N1  - https://doi.org/10.11648/j.ijcems.20190505.11
    DO  - 10.11648/j.ijcems.20190505.11
    T2  - International Journal of Clinical and Experimental Medical Sciences
    JF  - International Journal of Clinical and Experimental Medical Sciences
    JO  - International Journal of Clinical and Experimental Medical Sciences
    SP  - 62
    EP  - 66
    PB  - Science Publishing Group
    SN  - 2469-8032
    UR  - https://doi.org/10.11648/j.ijcems.20190505.11
    AB  - Long-chain omega-3 fatty acids have been positively related with improvement of fertility in both women and men. Primary natural source of omega-3- fatty acids is seafood. As this also can bei the source of toxicants like f.e. lead, mercury and cadmium, reproductive benefits may be counteracted. Therefore, our approach was to supplement pharmaceutical grade omega-3-fatty acids in order to assess potential benefits of omega-3-fatty acids on modulation of IVF-success by dietary measures in a well-defined group of patients of a German Fertility Centre. A group of 52 IVF-patients with a history of at least two miscarriages or unsuccessful in vitro fertilization approaches received periconceptual omega-3-fatty acid supplementation for a time period of at least 3 weeks. The “historical” control group, consisting of 1109 patients without omega-3-fatty acid supplementation, was generated out of the Fertility Centre´s patient database. The same inclusion criteria (history of at least two miscarriages or unsuccessful in vitro fertilization approaches) were applied for both groups. Omega-3-fatty acid supplementation lead to significantly enhanced in vitro fertilization success rates as well as to reduction of miscarriage rates compared to patients of the control group. The results encourage to design further age-matched, double-blinded prospective studies in order to verify a positive influence of dietary intervention and lifestyle modification on fertility rates.
    VL  - 5
    IS  - 5
    ER  - 

    Copy | Download

Author Information
  • Dental Concept, Praxis für Zahn, Mund-Und Kieferheilkunde, Voerde, Germany

  • Institut für Laboratoriumsmedizin, Mikrobiologie Und Hygiene, Evangelisches Klinikum Bethel, Bielefeld, Germany

  • Labor Todorov, Düsseldorf, Germany

  • Departments of Dermatology, Venereology, Allergology and Immunology, Dessau Medical Center, Brandenburg Medical School Theodor Fontane, Dessau, Germany

  • Section