American Journal of Pediatrics

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Risk Factors of Patent Ductus Arteriosus in Preterm

Received: Mar. 14, 2020    Accepted: Apr. 07, 2020    Published: Apr. 29, 2020
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Abstract

Patent Ductus Arteriosus (PDA) is one of acyanotic congenital heart diseases that often occurs in preterm infants and closely related to an increased risk of complications for sufferers. Identification of PDA risk factors in preterm infants is very important, so that the diagnosis and management can be done earlier. In this study we aimed to determine risk factors of PDA in preterm infants. This case-control study was conducted between July 2017 and April 2018, analysed 43 preterm infants with PDA as the case group and 43 preterm infants without PDA as the control group. The basic information related to characteristics, risk of infection and perinatal history in both groups were collected. Bivariate and multivariate analysis with logistic regression were performed to identify risk factors for PDA. We found several factors were identified significantly (P<0.05) as risk factors for PDA including premature rupture of membranes >12 hours (OR 7.25; 95% CI: 2.08 - 25.09) and thrombocytopenia in the first 24 hours (OR 15.11; 95% CI: 3.73 - 61.13). This study concluded premature rupture of membranes >12 hours and thrombocytopenia in the first 24 hours were proven to increase the risk of PDA in preterm infants.

DOI 10.11648/j.ajp.20200602.29
Published in American Journal of Pediatrics ( Volume 6, Issue 2, June 2020 )
Page(s) 168-172
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Risk Factor, PDA, Preterm, Thrombocytopenia, Premature Rupture of Membranes

References
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[2] Clyman RI, Couto J, Murphy, GM. Patent ductus arteriosus: are current neonatal treatment options better or worse than no treatment at all? Semin Perinatol. 2012; 36: 123-9.
[3] Pourarian S, Cheriki S, Sharma D, Bijanzadeh F, Farahbakhsh N. Prevalence and risk factors associated with the patency of ductus arteriosus in premature neonates: A prospective observational study from Iran. J Matern-Fetal Neo M. 2017; 30: 1460-4.
[4] Echtler K, Stark K, Lorenz M, Kerstan S. Platelets contribute to postnatal occlusion of the ductus arteriosus. Nat Med. 2010; 16: 75-82.
[5] Sallmon H, Weber SC, Huning B, Stein A, Horn PA, Metze BC, et al. Thrombocytopenia in the first 24 hours after birth and incidence of patent ductus arteriosus. Pediatrics. 2012; 130: 623-30.
[6] Chen YY, Wang HP, Chang JT, Chiou YH, Huang YF, Hsieh KS. Perinatal factors in patent ductus arteriosus in very low-birthweight infants. Pediatr Int. 2014; 56: 72-6.
[7] Hamrick SE, Hansmann G. Patent ductus arteriosus of the preterm infant. Pediatrics. 2010; 125: 1020-30.
[8] The ́baud B, Michelakis ED, Wu XC, Moudgil R, Kuzyk M. Oxygen-sensitive Kv channel gene transfer confers oxygen responsiveness to preterm rabbit and remodeled human ductus arteriosus: implications for infants with patent ductus arteriosus. Circulation. 2004; 110: 1372-9.
[9] Antonucci R, Bassareo P, Zaffanello M, Pusceddu M, Fanos V. Patent ductus arteriosus in the preterm infant: new insight into pathogenesis and clinical mana-gement. J Matern-Fetal Neo M. 2010; 23: 34-7.
[10] Fan F, Zhu S, Chen L, Zou Y, Fan L, Kang J. Role of prostaglandin E2 and its receptors in the process of ductus arteriosus maturation and functional closure in the rabbit. Clin Exp Pharmacol Physiol. 2010; 37: 574-80.
[11] Yajima I, Colombo S, Puig I, Champeval D, Kumasaka M, Belloir E. A subpopulation of smooth muscle cells, derived from melanocyte-competent precursors, prevents patent ductus arteriosus. PLoS One. 2013; 8: e 53183.
[12] Hermes-Desantis ER, Clyman RI. Patent ductus arteriosus: pathophysiology and management. J Perinatol. 2006; 26: 14-8.
[13] Simbolon D. Faktor risiko sepsis pada bayi baru lahir di RSUD Curup Kabupaten Rejang Lebong. Buletin Penelitian Kesehatan. 2008; 36: 127-34.
[14] Gonzalez A, Sosenko IR, Chandar J, Hummler H, Claure N, Bancalari E. Influence of infection on patent ductus arteriosus and chronic lung disease in premature infants weighing 1000 grams or less. J Pediatr. 1996; 128: 470-8.
[15] Simon SR, Zogchel L, Bas-Suarez MP, Cavallaro G, Clyman RI, Villamor E. Platelet counts and patent ductus arteriosus in preterm infants: a systematic review and meta-analysis. Neonatology. 2015; 108: 143-51.
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    Anak Agung Made Wijaya Kusuma, Eka Gunawijaya, I Gusti Ngurah Sanjaya Putra, Ni Putu Veny Kartika Yantie, I Made Kardana, et al. (2020). Risk Factors of Patent Ductus Arteriosus in Preterm. American Journal of Pediatrics, 6(2), 168-172. https://doi.org/10.11648/j.ajp.20200602.29

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    ACS Style

    Anak Agung Made Wijaya Kusuma; Eka Gunawijaya; I Gusti Ngurah Sanjaya Putra; Ni Putu Veny Kartika Yantie; I Made Kardana, et al. Risk Factors of Patent Ductus Arteriosus in Preterm. Am. J. Pediatr. 2020, 6(2), 168-172. doi: 10.11648/j.ajp.20200602.29

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    AMA Style

    Anak Agung Made Wijaya Kusuma, Eka Gunawijaya, I Gusti Ngurah Sanjaya Putra, Ni Putu Veny Kartika Yantie, I Made Kardana, et al. Risk Factors of Patent Ductus Arteriosus in Preterm. Am J Pediatr. 2020;6(2):168-172. doi: 10.11648/j.ajp.20200602.29

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  • @article{10.11648/j.ajp.20200602.29,
      author = {Anak Agung Made Wijaya Kusuma and Eka Gunawijaya and I Gusti Ngurah Sanjaya Putra and Ni Putu Veny Kartika Yantie and I Made Kardana and I Made Gede Dwi Lingga Utama and I Wayan Gustawan},
      title = {Risk Factors of Patent Ductus Arteriosus in Preterm},
      journal = {American Journal of Pediatrics},
      volume = {6},
      number = {2},
      pages = {168-172},
      doi = {10.11648/j.ajp.20200602.29},
      url = {https://doi.org/10.11648/j.ajp.20200602.29},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajp.20200602.29},
      abstract = {Patent Ductus Arteriosus (PDA) is one of acyanotic congenital heart diseases that often occurs in preterm infants and closely related to an increased risk of complications for sufferers. Identification of PDA risk factors in preterm infants is very important, so that the diagnosis and management can be done earlier. In this study we aimed to determine risk factors of PDA in preterm infants. This case-control study was conducted between July 2017 and April 2018, analysed 43 preterm infants with PDA as the case group and 43 preterm infants without PDA as the control group. The basic information related to characteristics, risk of infection and perinatal history in both groups were collected. Bivariate and multivariate analysis with logistic regression were performed to identify risk factors for PDA. We found several factors were identified significantly (P12 hours (OR 7.25; 95% CI: 2.08 - 25.09) and thrombocytopenia in the first 24 hours (OR 15.11; 95% CI: 3.73 - 61.13). This study concluded premature rupture of membranes >12 hours and thrombocytopenia in the first 24 hours were proven to increase the risk of PDA in preterm infants.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Risk Factors of Patent Ductus Arteriosus in Preterm
    AU  - Anak Agung Made Wijaya Kusuma
    AU  - Eka Gunawijaya
    AU  - I Gusti Ngurah Sanjaya Putra
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    AU  - I Made Kardana
    AU  - I Made Gede Dwi Lingga Utama
    AU  - I Wayan Gustawan
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    DO  - 10.11648/j.ajp.20200602.29
    T2  - American Journal of Pediatrics
    JF  - American Journal of Pediatrics
    JO  - American Journal of Pediatrics
    SP  - 168
    EP  - 172
    PB  - Science Publishing Group
    SN  - 2472-0909
    UR  - https://doi.org/10.11648/j.ajp.20200602.29
    AB  - Patent Ductus Arteriosus (PDA) is one of acyanotic congenital heart diseases that often occurs in preterm infants and closely related to an increased risk of complications for sufferers. Identification of PDA risk factors in preterm infants is very important, so that the diagnosis and management can be done earlier. In this study we aimed to determine risk factors of PDA in preterm infants. This case-control study was conducted between July 2017 and April 2018, analysed 43 preterm infants with PDA as the case group and 43 preterm infants without PDA as the control group. The basic information related to characteristics, risk of infection and perinatal history in both groups were collected. Bivariate and multivariate analysis with logistic regression were performed to identify risk factors for PDA. We found several factors were identified significantly (P12 hours (OR 7.25; 95% CI: 2.08 - 25.09) and thrombocytopenia in the first 24 hours (OR 15.11; 95% CI: 3.73 - 61.13). This study concluded premature rupture of membranes >12 hours and thrombocytopenia in the first 24 hours were proven to increase the risk of PDA in preterm infants.
    VL  - 6
    IS  - 2
    ER  - 

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Author Information
  • Department of Child Health, Udayana University Medical Faculty/Sanglah Hospital, Denpasar, Bali, Indonesia

  • Department of Child Health, Udayana University Medical Faculty/Sanglah Hospital, Denpasar, Bali, Indonesia

  • Department of Child Health, Udayana University Medical Faculty/Sanglah Hospital, Denpasar, Bali, Indonesia

  • Department of Child Health, Udayana University Medical Faculty/Sanglah Hospital, Denpasar, Bali, Indonesia

  • Department of Child Health, Udayana University Medical Faculty/Sanglah Hospital, Denpasar, Bali, Indonesia

  • Department of Child Health, Udayana University Medical Faculty/Sanglah Hospital, Denpasar, Bali, Indonesia

  • Department of Child Health, Udayana University Medical Faculty/Sanglah Hospital, Denpasar, Bali, Indonesia

  • Section