3. Results and Discussion
Table 1. Trends in estimated number of gout patients in Japan in 2004-2022.
Year | 2004 | 2007 | 2010 | 2013 | 2016 | 2019 | 2022 |
Gender | | | | million | | | |
Total | 0.874 | 0.854 | 0.957 | 1.063 | 1.105 | 1.254 | 1.306 |
Men | 0.790 | 0.779 | 0.904 | 0.993 | 1.048 | 1.195 | 1.236 |
Women | 0.083 | 0.074 | 0.053 | 0.069 | 0.057 | 0.059 | 0.070 |
Adapted from the Ministry of Health, Labour and Welfare in Japan
.
Table 2. Trends in estimated number of gout patients by generations in Japan in 1998, 2016, 2019, and 2022.
Year | 1998 | 2016 | 2019 | 2022 |
Years old | | Thousand | | |
Total | | | | |
15-24 | 2 | 4 | 3 | 1 |
25-34 | 15 | 17 | 19 | 22 |
35-44 | 68 | 84 | 83 | 79 |
45-54 | 124 | 180 | 206 | 211 |
55-64 | 159 | 270 | 296 | 315 |
65-74 | 152 | 340 | 393 | 415 |
75-84 | 61 | 173 | 216 | 214 |
≥ 85 | 9 | 35 | 38 | 48 |
Men | | | | |
15-24 | 2 | 4 | 2 | 1 |
25-34 | 14 | 16 | 19 | 20 |
35-44 | 67 | 81 | 82 | 78 |
45-54 | 116 | 177 | 204 | 207 |
55-64 | 137 | 261 | 288 | 302 |
65-74 | 125 | 326 | 373 | 396 |
75-84 | 43 | 155 | 199 | 192 |
≥ 85 | 6 | 27 | 28 | 39 |
Women | | | | |
15-24 | 0 | 0 | 0 | 0 |
25-34 | 1 | 1 | 0 | 2 |
35-44 | 1 | 1 | 0 | 1 |
45-54 | 8 | 4 | 1 | 4 |
55-64 | 22 | 9 | 9 | 12 |
65-74 | 27 | 14 | 20 | 19 |
75-84 | 18 | 19 | 17 | 21 |
≥ 85 | 3 | 8 | 10 | 9 |
Adapted from the Ministry of Health, Labour and Welfare in Japan
.
3.1. Prevalence of Gout in Japan
The number of gout patients going to hospitals estimated based on the Comprehensive Survey of Living Conditions conducted by the Ministry of Health, Labour and Welfare in Japan was 0.255 million in 1986, 0.283 million in 1989, 0.338 million in 1992, 0.423 million in 1995, 0.590 million in 1998, 0.696 million in 2001, 0.874 million in 2004, 0.854 million in 2007, 0.957 million in 2010, 1.063 million in 2013, 1.105 million in 2016, 1.254 million in 2019, and 1.306 million in 2022
(
Table 1). These values clearly indicate a steady increase in the number of patients with gout in Japan.
The number of gout patients in Japanese adult population (aged ≥ 20 years) in 2022 was estimated to be 1.306 million
. The number of gout patients in Japanese adult men (aged ≥ 20 years) and Japanese adult women (aged ≥ 20 years) in 2022 were estimated to be 1.236 million and 0.070 million, respectively
. Almost all gout patients were adults, and the number of gout patients were higher in men than in women.
3.2. Relationship Between Prevalence of Gout and Age in Japan
The number of gout patients in Japanese people are shown in
Table 2. The number of gout patients, especially men, increased with age in 1998-2022
. Japanese people who were 15-54 years old in 1998 increased gout patients after 2016. Compared to the number of total gout patients in Japanese people (aged 15-64 years) in 1998, the number of total gout patients in Japanese people (aged 35-84 years) in 2019 and 2022 markedly increased, approximately 20 years later
.
Compared to the number of total gout patients (aged ≥ 25 years) in 1998, the number of total gout patients (aged ≥ 25 years) in 2022 increased
. Compared to the number of total gout patients (aged ≥ 45 years) in 2016 and 2019, the number of total gout patients (aged ≥ 45 years) in 2022 increased, except the number of total gout patients (aged 75-84 years) in 2019
. The number of total gout patients of Japanese people who are 45-74 years old and ≥ 85 years old in 2022 were higher than those in 1998, 2016, and 2019. Compared to the number of gout patients in men (aged ≥ 25 years) in 1998, 2016, and 2019, the number of gout patients in men (aged ≥ 25 years) in 2022 increased, except the number of gout patients in men (aged 35-44 years) in 2016 and 2019, and men (aged 75-84 years) in 2019
. Whereas compared to the number of gout patients in women (aged 45-74 years) in 1998, the number of gout patients in women (aged 45-74 years) in 2022 decreased
. Compared to the number of gout patients (aged 25-34 years, ≥ 75 years) in 2016, the number of gout patients in women (aged 25-34 years, ≥ 75 years) in 2022 increased
. Compared to the number of gout patients in women (aged ≥ 55 years) in 2016 and 2019, the number of gout patients in women (aged ≥ 55 years) in 2022 increased, except the number of gout patients in women (aged 65-74 years, ≥ 85 years) in 2019
.
3.3. Relationship Between the Number of Gout Patients and Macronutrient Intake
The results on the correlation between the number of gout patients and macronutrient intake in Japanese people are shown in
Tables 3 and 4. Since gout patients of Japanese people were aged 15 year or older in 1998-2022, this article evaluated the intake of nutrients in Japanese people aged 15 year or older.
Table 3. Correlation between number of gout patients and macronutrient intake in Japanese people in 1986-2019 and 1986-2022.
Year | 1986-2019 | 1986-2022 |
Macronutrient | coefficient | coefficient |
Energy | - 0.938*** | - 0.919*** |
Total Carbohydrate | - 0.982*** | - 0.985*** |
Dietary Fiber | - 0.214 | 0.033 |
Carbohydrate/Energy | - 0.358 | - 0.519 |
Total Protein | - 0.887*** | - 0.855*** |
Animal Protein | - 0.709* | - 0.612* |
Vegetable Protein | - 0.960*** | - 0.956*** |
Protein/Energy | - 0.661* | - 0.637* |
Total Fat | - 0.210 | 0.055 |
Animal Fat | 0.242 | 0.433 |
Vegetable Fat | - 0.676* | - 0.502 |
Fat/Energy | 0.660* | 0.737** |
| 2004-2019 | 2004-2022 |
| coefficient | coefficient |
Cholesterol | 0.294 | 0.614 |
| 2007-2019 | 2007-2022 |
| coefficient | coefficient |
SFAs | 0.855 | 0.911* |
SFAs/Energy | 0.907* | 0.943** |
MUFAs | 0.860 | 0.915* |
n-3 PUFAs | - 0.098 | - 0.132 |
n-6 PUFAs | 0.776 | 0.867* |
The Pearson Product Moment Correlation coefficient, * for P<0.05, ** for P<0.01, *** for P<0.001.
Abbreviation: Carbohydrate/Energy, Mean ratio of energy intake from carbohydrate in total energy intake; Protein/Energy, Mean ratio of energy intake from protein in total energy intake; Fat/Energy, Mean ratio of energy intake from fat in total energy intake; SFAs, Saturated fatty acids; SFAs/Energy, Mean ratio of energy intake from saturated fatty acids in total energy intake; MUFAs, monounsaturated fatty acids; n-3 PUFAs, n-3 polyunsaturated fatty acids; n-6 PUFAs, n-6 polyunsaturated fatty acids.
Table 4. Correlation between number of gout patients and macronutrient intake in Japanese adult population, adult men, and adult women in 2004-2022.
Year | Adults | Adult men | Adult women |
2004-2022 | | coefficient | |
Macronutrient | | | |
Energy | 0.0137 | - 0.207 | 0.611 |
Total Carbohydrate | - 0.972*** | - 0.971*** | 0.554 |
Dietary Fiber | 0.831* | 0.834* | - 0.129 |
Carbohydrate/Energy | - 0.967*** | - 0.967*** | 0.316 |
Total Protein | 0.356 | 0.268 | 0.537 |
Animal Protein | 0.717 | 0.649 | 0.211 |
Vegetable Protein | - 0.616 | - 0.864* | 0.686 |
Protein/Energy | 0.646 | 0.681 | 0.299 |
Total Fat | 0.941** | 0.944** | - 0.250 |
Animal Fat | 0.949** | 0.947** | - 0.259 |
Vegetable Fat | 0.900** | 0.917** | - 0.199 |
Fat/Energy | 0.971*** | 0.975*** | - 0.396 |
Cholesterol | 0.703 | 0.651 | 0.100 |
2007-2022 | | coefficient | |
SFAs | 0.932** | 0.927** | 0.015 |
SFAs/Energy | 0.943** | 0.940** | - 0.029 |
MUFAs | 0.929** | 0.924** | 0.004 |
n-3 PUFAs | - 0.132 | - 0.220 | 0.065 |
n-6 PUFAs | 0.893* | 0.896* | 0.022 |
The Pearson Product Moment Correlation coefficient, * for P<0.05, ** for P<0.01, *** for P<0.001.
Abbreviation: Carbohydrate/Energy, Mean ratio of energy intake from carbohydrate in total energy intake; Protein/Energy, Mean ratio of energy intake from protein in total energy intake; Fat/Energy, Mean ratio of energy intake from fat in total energy intake; SFAs, Saturated fatty acids; SFAs/Energy, Mean ratio of energy intake from saturated fatty acids in total energy intake; MUFAs, monounsaturated fatty acids; n-3 PUFAs, n-3 polyunsaturated fatty acids; n-6 PUFAs, n-6 polyunsaturated fatty acids.
3.3.1. Energy
The daily energy intake of Japanese people in 2022 was lower compared to that in 1960, 1965, 1975, 1986, 1989, 1992, 1995, 1998, 2001, 2004, 2007, and 2019 and was higher compared to that in 2010, 2013, and 2016 (1960: 2096 kcal/day; 1965: 2184 kcal/day; 1975: 2188 kcal/day; 1986: 2075 kcal/day; 1989: 2061 kcal/day; 1992: 2058 kcal/day; 1995: 2042 kcal/day; 1998: 1979 kcal/day; 2001: 1954 kcal/day; 2004: 1902 kcal/day; 2007: 1898 kcal/day; 2010: 1849 kcal/day; 2013: 1873 kcal/day; 2016: 1865 kcal/day; 2019: 1903 kcal/day; 2022: 1888 kcal/day). The daily consumption of energy was negatively correlated with the number of gout patients in 1986-2019 (r= -0.938, p= 0.0000065) and in 1986-2022 (r= -0.919, p= 0.0000088).
The daily energy intake of Japanese adult population (aged ≥ 20 years) in 2022 was lower compared to that in 2019 (2019: 1915 kcal/day; 2022: 1896 kcal/day). The daily consumption of energy did not show a significant correlation with the number of gout patients in the adult population (aged ≥ 20 years) in 2004-2019 (r= -0.0133, p= 0.980) and in 2004-2022 (r= 0.0137, p= 0.977).
The daily energy intake of Japanese adult men (aged ≥ 20 years) and adult women (aged ≥ 20 years) in 2022 was lower compared to that in 2019, respectively (men: 2019: 2141 kcal/day; 2022: 2111 kcal/day, women: 2019: 1717 kcal/day; 2022: 1712 kcal/day). The daily consumption of energy did not show a significant correlation with the number of gout patients in adult men (aged ≥ 20 years) in 2004-2019 (r= -0.125, p= 0.814) and in 2004-2022 (r= -0.207, p= 0.656). The daily consumption of energy did not show a significant correlation with the number of gout patients in adult women (aged ≥ 20 years) in 2004-2019 (r= 0.599, p= 0.209) and in 2004-2022 (r= 0.611, p= 0.145).
The mean daily intake of energy for Japanese men (aged ≥ 20 years) and women (aged 20-59 years) in 2022 were 2064-2196 kcal/day and 1600-1720 kcal/day, respectively, and were below the estimation of energy requirement of low physical activity levels [physical activity levels: low: 2300 kcal/day; medium: 2650-2700 kcal/day; high: 3050 kcal/day among men; low: 1700-1750 kcal/day; medium: 2000-2050 kcal/day; high: 2300-2350 kcal/day among women]
. In Japanese men and women in 2022, the mean daily intake of energy for women (aged ≥ 60 years) was 1659-1763 kcal/day and was within the estimation of energy requirement of medium physical activity levels, and below the estimation of energy requirement of high physical activity levels [physical activity levels: low: 1400-1650 kcal/day; medium: 1650-2190 kcal/day; high: 2100-2250 kcal/day among women]
. The Institute of Medicine of the National Academy of Sciences in the U.S. has established the Estimate Energy Requirement (EER), which is defined as the average dietary energy intake that is predicted to maintain energy balance in a healthy adult of a defined age, gender, weight, height, and a level of physical activity that is consistent with good health
[27] | Institute of Medicine of the National Academy of Sciences. Food and Nutrition Board. Dietary Reference Intakes: The essential guide to nutrient requirements. Washington, D.C. The National Academy Press. Available from: https://www.nap.edu/catalog/11537.html (accessed 14 October 2021). |
[27]
.
A cross-sectional study using US National Health and Nutrition Examination Survey (NHANES) (2017-2018) data showed that dietary energy intake was positively correlated with SUA concentrations
[31] | Yao, J., Zhang, Y., Zhao, J., Lin, Y-P., Lu, Q-Y., Fan, G-J. Cor relation of obesity, dietary patterns, and blood pressure with uric acid: data from the NHANES 2017-2018. BMC Endocr Disord. 2022, 22(1), 196. https://doi.org/10.1186/s12902-022-01112-5 |
[31]
.
3.3.2. Carbohydrates
Carbohydrate
The daily carbohydrate intake of Japanese people in 2022 was lower compared to that in 1959, 1965, 1975, 1986, 1989, 1992, 1995, 1998, 2001, 2004, 2007, 2010, 2013, 2016, and 2019 (1959: 405 g/day; 1965: 384 g/day; 1975: 337 g/day; 1986: 295 g/day; 1989: 290 g/day; 1992: 289 g/day; 1995: 280 g/day; 1998: 271 g/day; 2001: 274 g/day; 2004: 266 g/day; 2007: 264 g/day; 2010: 258 g/day; 2013: 259 g/day; 2016: 252.8 g/day; 2019: 248.3 g/day; 2022: 244.8 g/day). The daily carbohydrate intake was negatively correlated with the number of gout patients in 1986-2019 (r= -0.982, p=0.0000000144) and in 1986-2022 (r= -0.985, p=0.000000000817).
The daily carbohydrate intake of Japanese adult population (aged ≥ 20 years) in 2022 was lower compared to that in 2019 (2019: 248.7 g/day; 2022: 245.1 g/day). The daily carbohydrate intake was negatively correlated with the number of gout patients in the adult population (aged ≥ 20 years) in 2004-2019 (r= -0.955, p=0.00301) and in 2004-2022 (r= -0.972, p= 0.000246).
The daily carbohydrate intake of Japanese adult men (aged ≥ 20 years) and adult women (aged ≥ 20 years) in 2022 were lower compared to those in 2019, respectively (men: 2019: 275.3 g/day; 2022: 269.9 g/day, women: 2019: 225.5 g/day; 2022: 223.8 g/day). The daily carbohydrate intake was negatively correlated with the number of gout patients in adult men (aged ≥ 20 years) in 2004-2019 (r= -0.959, p= 0.00249) and in 2004-2022 (r= -0.971, p= 0.000270). The daily carbohydrate intake tended to be positively correlated with the number of gout patients in adult women (aged ≥ 20 years) in 2004-2019 (r= 0.788, p= 0.0624). The daily carbohydrate intake did not show a significant correlation with the number of gout patients in adult women (aged ≥ 20 years) in 2004-2022 (r= 0.554, p= 0.197). This result suggests that the correlation of daily carbohydrate intake with the number of gout patients tends to vary with gender and is stronger in adult men than in adult women.
The Ministry of Health, Labour and Welfare in Japan
has not set the Recommended Dietary Allowances (RDAs) for the daily carbohydrate intake in Japanese people. The Recommended Dietary Allowances (RDAs) for carbohydrates (sugars and starches) in the U.S. population (aged ≥ 1 year) established by the Institute of Medicine of the National Academy of Sciences in the U.S. is 130 g/day
[27] | Institute of Medicine of the National Academy of Sciences. Food and Nutrition Board. Dietary Reference Intakes: The essential guide to nutrient requirements. Washington, D.C. The National Academy Press. Available from: https://www.nap.edu/catalog/11537.html (accessed 14 October 2021). |
[27]
.
The results of a recently published article are presented below. A cross-sectional study using US NHANES (2017-2018) data showed that dietary carbohydrate intake was negatively correlated with SUA concentrations
[31] | Yao, J., Zhang, Y., Zhao, J., Lin, Y-P., Lu, Q-Y., Fan, G-J. Cor relation of obesity, dietary patterns, and blood pressure with uric acid: data from the NHANES 2017-2018. BMC Endocr Disord. 2022, 22(1), 196. https://doi.org/10.1186/s12902-022-01112-5 |
[31]
. A cross-sectional study from China showed that every 10 g increase in energy-adjusted carbohydrate intakes caused a 5% decrease in hyperuricemia risk
[32] | Zhang, M., Ye, C., Wang, R., Zhang, Z., Huang, X., Halimulati, M., Sun, M., Ma, Y., Zhang, Z. Association between dietary acid load and hyperuricemia in Chinese adults: Analysis of the China Health and Nutrition Survey (2009). Nutrients. 2023, 15(8), 1806. https://doi.org/10.3390/nu15081806 |
[32]
.
A large-scale prospective cohort study based on the UK Biobank involving 500,000 individuals (aged 40-69 years) in 2006-2010 found that total carbohydrates, total sugars, non-free sugars, total starch, refined grain starch, wholegrain starch, and fiber intake were associated with a reduced risk of gout, whereas free sugars intake were associated with an increased risk of gout
[33] | Hua, B., Dong, Z., Yang, Y., Liu, W., Chen, S., Chen, Y., Sun, X., Ye, D., Li, J., Mao, Y. Dietary carbohydrates, genetic susceptibility, and gout risk; a prospective cohort study in the UK. Nutrients. 2024, 16(17), 2883. https://doi.org/10.3390/nu16172883 |
[33]
. This large-scale prospective cohort study found that total carbohydrates intake were associated with a reduced risk of gout; that is to say, individuals in the second level (230.50 - < 256.73 g/day), the third level (256.73 - < 281.42 g/day), the highest level (≥ 281.42 g/day) of the total carbohydrates intake were 21%, 31%, and 33% less likely to be gout compared to those individuals in the lowest intake level (< 230.50 g/day) (p for Trend = 3.073 × 10
-15)
[33] | Hua, B., Dong, Z., Yang, Y., Liu, W., Chen, S., Chen, Y., Sun, X., Ye, D., Li, J., Mao, Y. Dietary carbohydrates, genetic susceptibility, and gout risk; a prospective cohort study in the UK. Nutrients. 2024, 16(17), 2883. https://doi.org/10.3390/nu16172883 |
[33]
. Hua et al.
[33] | Hua, B., Dong, Z., Yang, Y., Liu, W., Chen, S., Chen, Y., Sun, X., Ye, D., Li, J., Mao, Y. Dietary carbohydrates, genetic susceptibility, and gout risk; a prospective cohort study in the UK. Nutrients. 2024, 16(17), 2883. https://doi.org/10.3390/nu16172883 |
[33]
revealed that SUA was identified as a significant mediator in all associations between total carbohydrates, total sugars, non-free sugars, total starch, refined grain starch, wholegrain starch, and fiber intake and gout risk. Detailed results are shown in the following sections.
Fructose
The Ministry of Health, Labour and Welfare in Japan has not investigated the daily fructose intake.
Previous reports
showed the association between fructose intake and SUA concentrations, hyperuricemia risk or gout risk referencing the results of clinical research (clinical trials and epidemiological studies) reported. These results suggest that excessive intake of fructose and fructose-rich foods (e.g., high-fructose corn syrup and sugar-sweetened beverages, soft drinks) may lead to hyperuricemia and gout.
The results of a recently published article are presented below. Lecoultre et al.
[34] | Lecoultre, V., Egli, L., Theytaz, F., Despland, C., Schneiter, P., Tappy, L. Fructose-induced hyperuricemia is associated with a decreased renal uric acid excretion in humans. Diabetes Care. 2013, 36(9), e149-e150. https://doi.org/10.2337/dc13-0866 |
[34]
found that fructose-induced hyperuricemia was associated with a decreased renal UA excretion in humans. Fang et al.
[35] | Fang, X-Y., Qi, L-W., Chen, H-F., Gao, P., Zhang, Q., Leng, R-X., Fan, Y-G., Li, B-Z., Pan, H-F., Ye, D-Q. The interaction between dietary fructose and gut microbiota in hyperuricemia and gout. Front Nutr. 2022, 9, 890730. https://doi.org/10.3389/fnut.2022.890730 |
[35]
also reviewed the interaction between dietary fructose or fructose-rich diet and gut microbiota in hyperuricemia and gout. They
[35] | Fang, X-Y., Qi, L-W., Chen, H-F., Gao, P., Zhang, Q., Leng, R-X., Fan, Y-G., Li, B-Z., Pan, H-F., Ye, D-Q. The interaction between dietary fructose and gut microbiota in hyperuricemia and gout. Front Nutr. 2022, 9, 890730. https://doi.org/10.3389/fnut.2022.890730 |
[35]
have stated that excessive fructose (especially in refined sugar and fruit juice) intake alters the gut microbiota composition and impairs intestinal barriers function through a series of inflammatory reactions, which play key roles in the pathogenesis of hyperuricemia and gout. A 10% fructose given intravenously (0.5 g/kg/h) for 2 hours increased blood lactate concentration, which may be attributable to decrease UA excretion via urate transporter 1 (URAT1/SLC22A12)
. Therefore, fructose intake has been shown to increase SUA level via both decreased UA excretion and increased UA production. In a systematic review and meta-analysis of controlled feeding trials, Wang et al.
[37] | Wang, D. D., Sievenpiper, J. L., de Souza, R. J., Chiavaroli, L., Ha, V., Cozma, A. I., Mirrahimi, A., Yu, M. E., Carleton, A. J., Buono, M. D., Jenkins, A. L., Leiter, L. A., Wolever, T. M. S., Beyene, J., Kendall, C. W. C., & Jenkins, D. J. A. (2012) The effects of fructose intake on serum uric acid vary among controlled dietary trials. J Nutr, 142, 916-923. https://doi.org/10.3945/jn.111.151951 |
[37]
have stated that high fructose intake (213-219 g/day) under hypercaloric feeding conditions (+35% excess energy) leads to increased risk of hyperuricemia and gout.
Anderson and Tulp
[38] | Anderson, M. E., Tulp, O. L. The effects of high dietary fructose consumption on the development of gout. ES J Public Health. 2023, 4, 1019. https://doi.org/10.59152/ESJPH/1019 |
[38]
have stated that the recommended safe and healthful daily fructose intake is not entirely defined; however, 25-50 grams a day is often indicated as safe, with 50-100 grams a day as being high, and over 100 grams a day as potentially dangerous for human consumption.
The Japanese Society of Gout and Uric & Nucleic Acids Guidelines
[6] | Hisatome, I., Ichida, K., Mineo, I., Ohtahara, A., Ogino, K., Kuwabara, M., Ishizaka, N., Uchida, S., Kurajoh, M., Kohagura, K., Sato, Y., Taniguchi, A., Tsuchihashi, T., Terai, C., Nakamura, T., Hamaguchi, T., Hamada, T., Fujimori, S., Masuda, I., Moriwaki, Y., Yamamoto, T. on behalf of guideline development group. Japanese Society of Gout and Uric & Nucleic Acids Guidelines for Management of Hyperuricemia and Gout: 3 rd edition. Tokyo: SHINDAN TO CHIRYO SHA, Inc.; 2018, pp. 1-169 (in Japanese). |
[6]
has recommended avoidance of fructose overdose in patients of gout. The 2020 American College of Rheumatology (ACR) Guideline
[39] | FitzGerald, J. D., Dalbeth, N., Mikuls, T., Brignardello-Petersen, R., Guyatt, G., Abeles, A. M., Gelber, A. C., Harrold, L. R., Khanna, D., King, C., Levy, G., Libbey, C., Mount, D., Pillinger, M. H., Rosenthal, A., Singh, J. A., Sims, J. E., Smith, B. J., Wenger, N. S., Bae, S. S., Danve, A., Khanna, P. P., Kim, S. C., Lenert, A., Poon, S., Qasim, A., Sehra, S. T., Sharma, T. S. K., Toprover, M., Turgunbaev, M., Zeng, L., Zhang, M. A., Turner, A. S., Neogi, T. 2020 American College of Rheumatology guideline for the management of gout. Arthritis Care Research. 2020, 72(6), 744-760. https://doi.org/10.1002/acr.24180 |
[39]
has conditionally recommended for limiting high-fructose for patients with gout, regardless of disease activity.
Foods high in fructose are as follows: raisins, date palm, dried figs, dried mango, dried tomatoes, dried kanpyo, dried apricots, dried prunes, ginger powder, grape, apple, dried banana, lychee, cherimoya, pear, cherry, kiwifruit, quince, gooseberry, persimmon, fig, mango, blueberry
.
Anderson and Tulp
[38] | Anderson, M. E., Tulp, O. L. The effects of high dietary fructose consumption on the development of gout. ES J Public Health. 2023, 4, 1019. https://doi.org/10.59152/ESJPH/1019 |
[38]
have stated that fructose as a limited normal constituent of fruits and vegetables has always likely been a minor constituent of the human diet, where it occurs in combination with dietary fibers, gums and other dietary components that collectively slow its rate of luminal absorption and postprandial disposal.
Sugars
Sugars from diets can be absorbed as glucose, galactose or fructose in the liver portal circulation. The liver and gut normally process galactose and fructose into lactate, glucose and organic acids through gluconeogenesis, glycogenolysis, aerobic oxidation and other pathway
. Metabolism of glucose, fructose or galactose is reviewed in detail by Chandel
.
The World Health Organization (WHO) has stated that the term “sugars” includes intrinsic sugars, which are those incorporated within the structure of intact fruit and vegetables; sugars from milk (lactose and galactose); and free sugars, which are monosaccharides and disaccharides added to foods and beverages by the manufacturer, cook or consumer, and sugars naturally present in honey, syrups, fruit juices and fruit juice concentrates
[41] | World Health Organization. Guideline: Sugars intake for adults and children. Geneva, Switzerland: WHO Press; 2015, pp. 1-49. |
[41]
.
The Ministry of Health, Labour and Welfare in Japan has not investigated the daily intake of sucrose, glucose and fructose. The Ministry of Health, Labour and Welfare in Japan
has not set the Recommended Dietary Allowances (RDAs) for the daily intake of sugars (monosaccharides, disaccharides, sugar alcohols) in Japanese people.
Considering the results of clinical research (clinical trials and epidemiological studies) reported, the previous reports
suggest excessive intake of sugars (particularly fructose and sucrose) may lead to hyperuricemia and gout. The detailed results of these articles have been described in the previous article
.
The results of a recently published article are presented below. A cross-sectional study using US NHANES (2017-2018) data showed that no statistical difference was found about the associations of dietary total sugars intake with SUA concentrations
[31] | Yao, J., Zhang, Y., Zhao, J., Lin, Y-P., Lu, Q-Y., Fan, G-J. Cor relation of obesity, dietary patterns, and blood pressure with uric acid: data from the NHANES 2017-2018. BMC Endocr Disord. 2022, 22(1), 196. https://doi.org/10.1186/s12902-022-01112-5 |
[31]
. In Mendelian randomization analysis, higher intake of sugar was associated with increased SUA levels
[42] | Ou, G., Wu, J., Wang, S., Jiang, Y., Chen, Y., Kong, J., Xu, H., Deng, L., Zhao, H., Chen, X., Xu, L. Dietary factors and risk of gout: a two-sample mendelian randomization study. Foods. 2024, 13(8), 1269. https://doi.org/10.3390/foods13081269 |
[42]
. An isocaloric sucrose diet in gouty patients increased SUA concentrations
[43] | Fox, I. H., John, D., DeBruyne, S., Dwosh, I., Marliss, E. B. Hyperuricemia and hypertriglyceridemia: metabolic basis for the association. Metabolism. 1985, 34(8), 741-746. https://doi.org/10.1016/0026-0495(85)90025-3 |
[43]
.
A large-scale prospective cohort study found that free sugars intake were associated with an increased risk of gout; that is to say, individuals in the second level (42.44 -< 5 7.73 g/day), the highest level (≥ 75.61 g/day) of the free sugars intake were 1% and 15% more likely to be gout compared to those individuals in the lowest intake level (< 42.44 g/day), respectively and individuals in the third level (57.73 - < 75.61 g/day) of the free sugars intake was 1% less likely to be gout compared to those individuals in the lowest intake level (< 42.44 g/day) (p for Trend = 0.014)
[33] | Hua, B., Dong, Z., Yang, Y., Liu, W., Chen, S., Chen, Y., Sun, X., Ye, D., Li, J., Mao, Y. Dietary carbohydrates, genetic susceptibility, and gout risk; a prospective cohort study in the UK. Nutrients. 2024, 16(17), 2883. https://doi.org/10.3390/nu16172883 |
[33]
. Whereas total sugars and non-free sugars intake were associated with a reduced risk of gout; that is to say, individuals in the second level (100.97 - < 122.91 g/day), the third level (122.91 - < 146.72 g/day), the highest level (≥ 146.72 g/day) of the total sugars intake were 16%, 18%, and 11% less likely to be gout compared to those individuals in the lowest intake level (< 100.97 g/day) (p for Trend = 0.018)
[33] | Hua, B., Dong, Z., Yang, Y., Liu, W., Chen, S., Chen, Y., Sun, X., Ye, D., Li, J., Mao, Y. Dietary carbohydrates, genetic susceptibility, and gout risk; a prospective cohort study in the UK. Nutrients. 2024, 16(17), 2883. https://doi.org/10.3390/nu16172883 |
[33]
. Furthermore, non-free sugars intake were associated with a reduced risk of gout; that is to say, individuals in the second level (43.88 - < 60.70 g/day), the third level (60.70 - < 80.04 g/day), the highest level (≥ 80.04 g/day) of the non-free sugars intake were 22%, 28%, and 30% less likely to be gout compared to those individuals in the lowest intake level (< 43.88 g/day) (p for Trend = 2.100 × 10
-11)
[33] | Hua, B., Dong, Z., Yang, Y., Liu, W., Chen, S., Chen, Y., Sun, X., Ye, D., Li, J., Mao, Y. Dietary carbohydrates, genetic susceptibility, and gout risk; a prospective cohort study in the UK. Nutrients. 2024, 16(17), 2883. https://doi.org/10.3390/nu16172883 |
[33]
.
Tappy et al.
[44] | Tappy, L., Morio, B., Azzout-Mamiche, D., Champ, M., Gerber, M., Houdart, S., Mas, E., Rizkalia, S., Slama, G., Mariotti, F., Margaritis, I. French recommendations for sugar intake in adults: a novel approach chosen by ANSES. Nutrients. 2018, 10(8), 989. https://doi.org/10.3390/nu10080989 |
[44]
have proposed to set a maximum limit to the intake of total sugars containing fructose (sucrose, glucose fructose syrups, honey or other syrups, and natural concentrates, etc.) of 100 g/day. Recommendation for added sugars naturally present in established by the Institute of Medicine of the National Academy of Sciences in the U.S. suggests limit to a maximal intake of no more than 25 percent total energy
[27] | Institute of Medicine of the National Academy of Sciences. Food and Nutrition Board. Dietary Reference Intakes: The essential guide to nutrient requirements. Washington, D.C. The National Academy Press. Available from: https://www.nap.edu/catalog/11537.html (accessed 14 October 2021). |
[27]
. The World Health Organization (WHO) recommends reducing the intake of free sugars to less than 10% of total energy intake in both adults and children and suggests a further reduction of the intake of free sugars to below 5% of total energy intake
[41] | World Health Organization. Guideline: Sugars intake for adults and children. Geneva, Switzerland: WHO Press; 2015, pp. 1-49. |
[41]
. The 2015-2020 Edition of the Dietary Guidelines for Americans
recommends consuming less than 10% calories per day from added sugar and does not include sugars fruit juices added sugars. The Joint WHO/FAO Expert Consultation
[46] | Nishida, C., Uauy, R., Kumanyika, S., & Shetty, P. The joint WHO/FAO expert consultation on diet, nutrition and the prevention of chronic diseases: process, product and policy implications. Public Health Nutr. 2004, 7(1A), 245-250. https://doi.org/10.1079/phn2003592 |
[46]
has stated that the recommended intake of free sugars is < 10% of energy.
The 2012 American College of Rheumatology (ACR) Guidelines for Management of Gout
[10] | Khanna, D., Fitzgerald, J. D., Khanna, P. P., Bae, S., Singh, M. K., Neogi, T., Pillinger, M. H., Merill, J., Lee, S., Prakash, S., Kaldas, M., Gogia, M., Perez-Ruiz, F., Taylor, W., Lioté, F., Choi, H., Singh, J. A., Dalbeth, N., Kaplan, S., Niyyar, V., Jones, D., Yarows, S. A., Roessler, B., Kerr, G., King, C., Levy, G., Furst, D. E., Edwards, N. L., Mandell, B., Schumacher, H. R., Robbins, M., Wenger, N., Terkeltaub, R. 2012 American College of Rheumatology guidelines for management of gout. Part 1: systematic nonpharmacologic and pharmacologic therapeutic approaches to hyperuricemia. Arthritis Care Research. 2012, 64(10), 1431-1446. https://doi.org/10.1002/acr.21772 |
[10]
has recommended limiting intake of table sugar in all gout patients. The Italian Society of Rheumatology clinical practice guidelines for the diagnosis and management of gout
[47] | Ughi, N., Prevete, I., Ramonda, R., Cavagna, L., Filippou, G., Manara, M., Bortoluzzi, A., Parisi, S., Ariani, A., Scirè, C. A. The Italian Society of Rheumatology clinical practice guidelines for the diagnosis and management of gout. Reumatismo, 2019, 71 (S1), 50-79. https://doi.org/10.4081/reumatismo.2019.1176 |
[47]
has recommended low in added sugars.
As described in the previous articles
, it should pay attention to not to excessive intake of sugars (particularly fructose and sucrose) to prevent hyperuricemia and/or gout.
Starches
The Ministry of Health, Labour and Welfare in Japan has not investigated the daily starch intake.
A large-scale prospective cohort study based on the UK Biobank involving 500,000 individuals (aged 40-69 years) in 2006-2010 found that total starch, refined grain starch, wholegrain starch intake were associated with a reduced risk of gout; that is to say, individuals in the second level (109.29 - < 129.26 g/day), the third level (129.26 - < 149.44 g/day), the highest level (≥ 149.44 g/day) of the total starch intake were 19%, 28%, and 30% less likely to be gout compared to those individuals in the lowest intake level (< 109.29 g/day) (p for Trend = 7.254 × 10
-12)
[33] | Hua, B., Dong, Z., Yang, Y., Liu, W., Chen, S., Chen, Y., Sun, X., Ye, D., Li, J., Mao, Y. Dietary carbohydrates, genetic susceptibility, and gout risk; a prospective cohort study in the UK. Nutrients. 2024, 16(17), 2883. https://doi.org/10.3390/nu16172883 |
[33]
. Refined grain starch intake were associated with a reduced risk of gout; that is to say, individuals in the second level (96.21 - < 153.17 g/day), the third level (153.17 - < 222.30 g/day), the highest level (≥ 222.30 g/day) of the refined grain starch intake were 9%, 12%, and 15% less likely to be gout compared to those individuals in the lowest intake level (< 96.21 g/day) (p for Trend = 0.002)
[33] | Hua, B., Dong, Z., Yang, Y., Liu, W., Chen, S., Chen, Y., Sun, X., Ye, D., Li, J., Mao, Y. Dietary carbohydrates, genetic susceptibility, and gout risk; a prospective cohort study in the UK. Nutrients. 2024, 16(17), 2883. https://doi.org/10.3390/nu16172883 |
[33]
. Furthermore, wholegrain starch intake were associated with a reduced risk of gout; that is to say, individuals in the second level (45.99 - < 96.03 g/day), the third level (96.03 - < 162.67 g/day), the highest level (≥ 162.67 g/day) of the wholegrain starch intake were 5%, 19%, and 27% less likely to be gout compared to those individuals in the lowest intake level (< 45.99 g/day) (p for Trend = 1.536 × 10
-9)
[33] | Hua, B., Dong, Z., Yang, Y., Liu, W., Chen, S., Chen, Y., Sun, X., Ye, D., Li, J., Mao, Y. Dietary carbohydrates, genetic susceptibility, and gout risk; a prospective cohort study in the UK. Nutrients. 2024, 16(17), 2883. https://doi.org/10.3390/nu16172883 |
[33]
.
Dietary Fiber
The daily intake of dietary fiber of Japanese people in 2022 was lower compared to that in 1951, 1955, 1960, 1975, and 2019 and was higher compared to that in 1986, 1989, 1992, 1998, 2001, 2004, 2007, 2010, 2013, and 2016 and was the same as that in 1966 (1951: 23.3 g/day; 1955: 23.0 g/day; 1960: 19.9 g/day; 1966: 18.1 g/day; 1975: 18.3 g/day; 1986: 16.6 g/day; 1989: 16.4 g/day; 1992: 16.4 g/day; 1998: 15.0 g/day; 2001: 14.6 g/day; 2004: 13.9 g/day; 2007: 14.6 g/day; 2010: 14.0 g/day; 2013: 14.2 g/day; 2016: 14.2 g/day; 2019: 18.4 g/day; 2022: 18.1 g/day). The daily dietary fiber intake did not show a significant correlation with the number of gout patients in 1986-2019 (r= -0.214, p= 0.476) and in 1986-2022 (r= 0.033, p= 0.918).
The daily intake of dietary fiber of Japanese adult population (aged ≥ 20 years) in 2022 was lower compared to that in 2019 (2019: 18.8 g/day; 2022: 18.5 g/day). The daily intake of dietary fiber did not show a significant correlation with the number of gout patients in the adult population (aged ≥ 20 years) in 2004-2019 (r= 0.730, p= 0.0994). Whereas the daily dietary fiber intake was positively correlated with the number of gout patients in the adult population (aged ≥ 20 years) in 2004-2022 (r= 0.831, p= 0.0206).
The daily dietary fiber intake of Japanese adult men (aged ≥ 20 years) and adult women (aged ≥ 20 years) in 2022 were lower compared to that in 2019, respectively (men: 2019: 19.9 g/day; 2022: 19.5 g/day, women: 2019: 18.0 g/day; 2022: 17.6 g/day). The daily intake of dietary fiber did not show a significant correlation with the number of gout patients in adult men (aged ≥ 20 years) in 2004-2019 (r= 0.742, p= 0.0913). Whereas the daily dietary fiber intake was positively correlated with the number of gout patients in adult men (aged ≥ 20 years) in 2004-2022 (r= 0.834, p= 0.0198). The daily intake of dietary fiber did not show a significant correlation with the number of gout patients in adult women (aged ≥ 20 years) in 2004-2019 (r= -0.270, p= 0.605) and in 2004-2022 (r= -0.129, p= 0.782). This result suggests that the correlation of the daily intake of dietary fiber with the number of gout patients varies with gender.
The daily intake of dietary fiber of Japanese men (aged ≥ 15 years) in 2022 was about the same as that in 2019 (2019: 17.5-21.4 g/day; 2022: 17.6-21.5 g/day). The daily intake of dietary fiber of Japanese women (aged ≥ 15 years) in 2022 was about the same as that in 2019 (2019: 14.6-19.8 g/day; 2022: 13.7-20.1 g/day). The daily dietary fiber intake of Japanese men (aged 20-59 years) and women (aged 20-59 years) in 2022 were 17.6-18.9 g/day (8.37-8.90 g/1000kcal) and 13.7-16.9 g/day (8.56-9.83 g/1000kcal), respectively, and were below the Tentative Dietary Goal for Preventing Lifestyle-related Diseases (DG) established by the Ministry of Health, Labour and Welfare in Japan [men (aged 18-64 years): ≥ 21 g/day; women (aged 15-64 years): ≥ 18 g/day]
. The daily dietary fiber intake of Japanese men (aged ≥ 70 years) and women (aged ≥ 60 years) were 21.5 g/day (10.86 g/1000kcal) and 18.6-20.1 g/day (10.55-11.40 g/1000kcal), respectively, and were above the DG established by the Ministry of Health, Labour and Welfare in Japan [men (aged ≥ 65 years): ≥ 20 g/day; women (aged 15-64 years): ≥ 18 g/day; women (aged ≥ 65 years): ≥ 17 g/day]
. The U.S. Department of Agriculture (USDA) has recommended that daily dietary fiber intake is 14 g/1000kcal, for an average age adult, this means a daily intake of 25 g (female) or 38 g (male) in the U.S.
. Recommended Adequate Intakes (AIs) for total fiber (the sum of dietary fiber and functional fiber) in the U.S. population (aged ≥ 1 year) established by the Institute of Medicine of the National Academy of Sciences in the U.S. is 14 g/1,000 kcal [men (aged 14-50 years): 38 g/day; men (aged ≥ 51 years): 30 g/day; women (aged 9-18 years): 26 g/day; women (aged 19-50 years): 25 g/day; women (aged ≥ 51 years): 21 g/day]
[27] | Institute of Medicine of the National Academy of Sciences. Food and Nutrition Board. Dietary Reference Intakes: The essential guide to nutrient requirements. Washington, D.C. The National Academy Press. Available from: https://www.nap.edu/catalog/11537.html (accessed 14 October 2021). |
[27]
. The daily intake of dietary fiber of Japanese men (aged ≥ 15 years) in 2022 was below the AIs established by the Institute of Medicine of the National Academy of Sciences in the U.S.
[27] | Institute of Medicine of the National Academy of Sciences. Food and Nutrition Board. Dietary Reference Intakes: The essential guide to nutrient requirements. Washington, D.C. The National Academy Press. Available from: https://www.nap.edu/catalog/11537.html (accessed 14 October 2021). |
[27]
. The Nordic Nutrition Recommendations 2012
[48] | Carlsen, H., Pajari, A-M. Dietary fiber – a scoping review for Nordic Nutrition Recommendations 2023. Food & Nutrition Research. 2023, 67, 9979. https://doi.org/10.29219/fnr.v67.9979 eCollection 2023 |
[48]
has stated that the recommended intake of dietary fiber is 35 g/d for men and 25 g/d for women and dietary fiber is beneficial for health, advocating intakes of at least 25 g/day. Results of the German National Nutrition Monitoring (NEMONIT)
[49] | Gose, M., Krems, C., Heuer, T., Hoffmann, I. Trends in food consumption and nutrient intake in Germany between 2006 and 2012: results of the German National Nutrition Monitoring (NEMONIT). Br J Nutr. 2016, 115(8), 1498-1507. https://doi.org/10.1017/S0007114516000544 |
[49]
have shown that adults are recommended to consume over 30 g/day of fiber. The European Food Safety Authority
[50] | European Food Safety Authority. Scientific opinion on dietary reference values for carbohydrates and dietary fibre 1EFSA panel on dietetic products, nutrition, and allergies (NDA). EFSA J. 2010, 8, 1462. |
[50]
has recommended 25 g as the sufficient fiber consumption in adults. The Joint WHO/FAO Expert Consultation
[46] | Nishida, C., Uauy, R., Kumanyika, S., & Shetty, P. The joint WHO/FAO expert consultation on diet, nutrition and the prevention of chronic diseases: process, product and policy implications. Public Health Nutr. 2004, 7(1A), 245-250. https://doi.org/10.1079/phn2003592 |
[46]
has stated that the recommended intake of dietary fiber is > 25 g/day for adults for preventing obesity, diabetes, cardiovascular diseases and various cancers. Therefore, the daily dietary fiber intake for Japanese adult men and women (aged ≥ 20 years) were below the recommendation by the U.S. Department of Agriculture (USDA)
, the Nordic Nutrition Recommendations 2012
[48] | Carlsen, H., Pajari, A-M. Dietary fiber – a scoping review for Nordic Nutrition Recommendations 2023. Food & Nutrition Research. 2023, 67, 9979. https://doi.org/10.29219/fnr.v67.9979 eCollection 2023 |
[48]
, the German National Nutrition Monitoring (NEMONIT)
[49] | Gose, M., Krems, C., Heuer, T., Hoffmann, I. Trends in food consumption and nutrient intake in Germany between 2006 and 2012: results of the German National Nutrition Monitoring (NEMONIT). Br J Nutr. 2016, 115(8), 1498-1507. https://doi.org/10.1017/S0007114516000544 |
[49]
, The European Food Safety Authority
[50] | European Food Safety Authority. Scientific opinion on dietary reference values for carbohydrates and dietary fibre 1EFSA panel on dietetic products, nutrition, and allergies (NDA). EFSA J. 2010, 8, 1462. |
[50]
, and The Joint WHO/FAO Expert Consultation
[46] | Nishida, C., Uauy, R., Kumanyika, S., & Shetty, P. The joint WHO/FAO expert consultation on diet, nutrition and the prevention of chronic diseases: process, product and policy implications. Public Health Nutr. 2004, 7(1A), 245-250. https://doi.org/10.1079/phn2003592 |
[46]
.
In epidemiological studies, increased dietary fiber intake was associated with decreased SUA concentrations
[31] | Yao, J., Zhang, Y., Zhao, J., Lin, Y-P., Lu, Q-Y., Fan, G-J. Cor relation of obesity, dietary patterns, and blood pressure with uric acid: data from the NHANES 2017-2018. BMC Endocr Disord. 2022, 22(1), 196. https://doi.org/10.1186/s12902-022-01112-5 |
[51] | Zykova, S. N., Storhaug, H. M., Toft, I., Chadban, S. J., Jenssen, T. G., White, S. L. Cross-sectional analysis of nutrition and serum uric acid in two Caucasian cohorts: the AusDiab Study and the Tromsø study. Nutr J. 2015, 14, 49. https://doi.org/10.1186/s12937-015-0032-1 |
[52] | Sun, S. Z., Flickinger, B. D., Williamson-Hughes, P. S., Empie, M. W. Lack of association between dietary fructose and hyperuricemia risk in adults. Nutr Metab (Lond). 2010, 7, 16. https://doi.org/10.1186/1743-7075-7-16 |
[53] | So, M. W., Lim, D-H., Kim, S-H., Lee, S. Dietary and nutritional factors associated with hyperuricemia: The seventh Korean National Health and Nutrition Examination Survey. Asia Pac J Clin Nutr. 2020, 29(3), 609-617. https://doi.org/10.6133/apjcn.202009_29(3).0021 |
[54] | Shatat, I. F., Abdallah, R. T., Sas, D. J., Hailpern, S. M. Serum uric acid in US adolescents: distribution and relationship to demographic characteristics and cardiovascular risk factors. Pediatric Research. 2012, 72(1), 95-100. https://doi.org/10.1038/pr.2012.47 |
[55] | Zhu, Q., Yu, L., Li, Y., Man, Q., Jia, S., Zhou, Y., Zuo, H., Zhang, J. Association between dietary fiber intake and hyperuricemia among Chinese adults: Analysis of the China Adult Chronic Disease and Nutrition Surveillance (2015). Nutrients. 2022, 14(7), 1433. https://doi.org/10.3390/nu14071433 |
[56] | Kim, J., Jung, D. Y., Lee, J-H., Kim, M. K., Kwon, H-S., Yim, H. W., Moon, S-J. Association between serum uric acid levels and dietary fiber intake in adults: the Korea national health and nutrition examination survey (KNHANES VII, 2016-2018). Nutr Metab (Lond). 2024, 21(1), 33. https://doi.org/10.1186/s12986-024-00809-9 |
[31, 51-56]
, hyperuricemia risk
[32] | Zhang, M., Ye, C., Wang, R., Zhang, Z., Huang, X., Halimulati, M., Sun, M., Ma, Y., Zhang, Z. Association between dietary acid load and hyperuricemia in Chinese adults: Analysis of the China Health and Nutrition Survey (2009). Nutrients. 2023, 15(8), 1806. https://doi.org/10.3390/nu15081806 |
[51] | Zykova, S. N., Storhaug, H. M., Toft, I., Chadban, S. J., Jenssen, T. G., White, S. L. Cross-sectional analysis of nutrition and serum uric acid in two Caucasian cohorts: the AusDiab Study and the Tromsø study. Nutr J. 2015, 14, 49. https://doi.org/10.1186/s12937-015-0032-1 |
[52] | Sun, S. Z., Flickinger, B. D., Williamson-Hughes, P. S., Empie, M. W. Lack of association between dietary fructose and hyperuricemia risk in adults. Nutr Metab (Lond). 2010, 7, 16. https://doi.org/10.1186/1743-7075-7-16 |
[53] | So, M. W., Lim, D-H., Kim, S-H., Lee, S. Dietary and nutritional factors associated with hyperuricemia: The seventh Korean National Health and Nutrition Examination Survey. Asia Pac J Clin Nutr. 2020, 29(3), 609-617. https://doi.org/10.6133/apjcn.202009_29(3).0021 |
[55] | Zhu, Q., Yu, L., Li, Y., Man, Q., Jia, S., Zhou, Y., Zuo, H., Zhang, J. Association between dietary fiber intake and hyperuricemia among Chinese adults: Analysis of the China Adult Chronic Disease and Nutrition Surveillance (2015). Nutrients. 2022, 14(7), 1433. https://doi.org/10.3390/nu14071433 |
[56] | Kim, J., Jung, D. Y., Lee, J-H., Kim, M. K., Kwon, H-S., Yim, H. W., Moon, S-J. Association between serum uric acid levels and dietary fiber intake in adults: the Korea national health and nutrition examination survey (KNHANES VII, 2016-2018). Nutr Metab (Lond). 2024, 21(1), 33. https://doi.org/10.1186/s12986-024-00809-9 |
[57] | Yu, K-H., See, L-C., Huang, Y-C., Yang, C-H., Sun, J-H. Dietary factors associated with hyperuricemia in adults. Semin Arthritis Rheum. 2008, 37(4), 243-250. https://doi.org/10.1016/j.semarthrit.2007.04.007 |
[58] | Sun, Y., Sun, J., Zhang, P., Zhong, F., Cai, J., Ma, A. Association of dietary fiber intake with hyperuricemia in U.S. adults. Food Funct. 2019, 10(8), 4932-4940. https://doi.org/10.1039/c8fo01917g |
[32, 51-53, 55-58]
, and gout risk
[33] | Hua, B., Dong, Z., Yang, Y., Liu, W., Chen, S., Chen, Y., Sun, X., Ye, D., Li, J., Mao, Y. Dietary carbohydrates, genetic susceptibility, and gout risk; a prospective cohort study in the UK. Nutrients. 2024, 16(17), 2883. https://doi.org/10.3390/nu16172883 |
[59] | Lyu, L. C., Hsu, C. Y., Yeh, C. Y., Lee, M. S., Huang, S. H., Chen, C. L. A case-control study of the association of diet and obesity with gout in Taiwan. Am J Clin Nutr. 2003, 78(4), 690-701. https://doi.org/10.1093/ajcn/78.4.690 |
[33, 59]
. In a clinical trial, dietary fiber decreased serum uric acid (SUA) concentrations
[60] | Yamaguchi, Y., Ando, C., Tsukamoto, S., Nagao, J., Ueda, T., Yamaguchi, H., & Akaoka, I. (2007) The effect on the serum uric acid level of long-term intake of chitosan-supplemented food and its safety in adults. J Jpn Soc Clin Nutr, 29, 104-113 (in Japanese). |
[61] | Carabin, I. G., Lyon, M. R., Wood, S., Pelletier, X., Donazzolo, Y., Burdock, G. A. Supplementation of the diet with the functional fiber PolyGlycoplex is well tolerated by healthy subjects in a clinical trial. Nutr J. 2009, 8, 9. https://doi.org/10.1186/1475-2891-8-9 |
[60, 61]
. The previous article
showed that the detailed results of effect of dietary fiber on SUA concentrations and hyperuricemia risk
[51] | Zykova, S. N., Storhaug, H. M., Toft, I., Chadban, S. J., Jenssen, T. G., White, S. L. Cross-sectional analysis of nutrition and serum uric acid in two Caucasian cohorts: the AusDiab Study and the Tromsø study. Nutr J. 2015, 14, 49. https://doi.org/10.1186/s12937-015-0032-1 |
[52] | Sun, S. Z., Flickinger, B. D., Williamson-Hughes, P. S., Empie, M. W. Lack of association between dietary fructose and hyperuricemia risk in adults. Nutr Metab (Lond). 2010, 7, 16. https://doi.org/10.1186/1743-7075-7-16 |
[53] | So, M. W., Lim, D-H., Kim, S-H., Lee, S. Dietary and nutritional factors associated with hyperuricemia: The seventh Korean National Health and Nutrition Examination Survey. Asia Pac J Clin Nutr. 2020, 29(3), 609-617. https://doi.org/10.6133/apjcn.202009_29(3).0021 |
[55] | Zhu, Q., Yu, L., Li, Y., Man, Q., Jia, S., Zhou, Y., Zuo, H., Zhang, J. Association between dietary fiber intake and hyperuricemia among Chinese adults: Analysis of the China Adult Chronic Disease and Nutrition Surveillance (2015). Nutrients. 2022, 14(7), 1433. https://doi.org/10.3390/nu14071433 |
[58] | Sun, Y., Sun, J., Zhang, P., Zhong, F., Cai, J., Ma, A. Association of dietary fiber intake with hyperuricemia in U.S. adults. Food Funct. 2019, 10(8), 4932-4940. https://doi.org/10.1039/c8fo01917g |
[60] | Yamaguchi, Y., Ando, C., Tsukamoto, S., Nagao, J., Ueda, T., Yamaguchi, H., & Akaoka, I. (2007) The effect on the serum uric acid level of long-term intake of chitosan-supplemented food and its safety in adults. J Jpn Soc Clin Nutr, 29, 104-113 (in Japanese). |
[61] | Carabin, I. G., Lyon, M. R., Wood, S., Pelletier, X., Donazzolo, Y., Burdock, G. A. Supplementation of the diet with the functional fiber PolyGlycoplex is well tolerated by healthy subjects in a clinical trial. Nutr J. 2009, 8, 9. https://doi.org/10.1186/1475-2891-8-9 |
[51-53, 55, 58, 60, 61]
. Dietary fiber intake may prevent gout through reduced SUA concentrations and decreased hyperuricemia risk. The previous articles
describe a possible mechanism for the suppression of elevation of SUA concentrations of fiber ingested in experimental hyperuricemia model in animal species. It seems that increase intake of carbohydrate (particularly dietary fiber) may play an important role for the prevention of gout.
The results of a recently published article are presented below. A cross-sectional study using US NHANES (2017-2018) data showed that dietary fiber intake was negatively correlated with SUA concentrations
[31] | Yao, J., Zhang, Y., Zhao, J., Lin, Y-P., Lu, Q-Y., Fan, G-J. Cor relation of obesity, dietary patterns, and blood pressure with uric acid: data from the NHANES 2017-2018. BMC Endocr Disord. 2022, 22(1), 196. https://doi.org/10.1186/s12902-022-01112-5 |
[31]
. A cross-sectional study from China showed that every 10 g increase in energy-adjusted dietary fiber intakes caused a 13% decrease in hyperuricemia risk
[32] | Zhang, M., Ye, C., Wang, R., Zhang, Z., Huang, X., Halimulati, M., Sun, M., Ma, Y., Zhang, Z. Association between dietary acid load and hyperuricemia in Chinese adults: Analysis of the China Health and Nutrition Survey (2009). Nutrients. 2023, 15(8), 1806. https://doi.org/10.3390/nu15081806 |
[32]
. A cross-sectional study survey using the seventh Korean National Health and Nutrition Examination Survey 2016-2018 data collected for 15278 subjects (6455 men and 8823 women) (aged ≥ 20 years) showed that dietary fiber intake was inversely associated with SUA concentrations in both men and women
[56] | Kim, J., Jung, D. Y., Lee, J-H., Kim, M. K., Kwon, H-S., Yim, H. W., Moon, S-J. Association between serum uric acid levels and dietary fiber intake in adults: the Korea national health and nutrition examination survey (KNHANES VII, 2016-2018). Nutr Metab (Lond). 2024, 21(1), 33. https://doi.org/10.1186/s12986-024-00809-9 |
[56]
. Consuming more than 27.9 g of dietary fiber in men and 20.7 g in women reduced hyperuricemia risk by 28% and 29% in men and women, respectively [hyperuricemia: SUA concentration ≥ 7.0 mg/dL (416.4 µmol/L) in men and ≥ 6.0 mg/dL (356.9 µmol/L) in women]. Men in the highest quartile of intake of total dietary fiber, cereal fiber, vegetable fiber, and fruit fiber were 38.9%, 29.7%, 23.9%, and 28.4% less likely to be hyperuricemia [SUA concentration ≥ 7.0 mg/dL (416.4 µmol/L) in men] compared to those subjects in the lowest quartile of each fiber intake, respectively
[56] | Kim, J., Jung, D. Y., Lee, J-H., Kim, M. K., Kwon, H-S., Yim, H. W., Moon, S-J. Association between serum uric acid levels and dietary fiber intake in adults: the Korea national health and nutrition examination survey (KNHANES VII, 2016-2018). Nutr Metab (Lond). 2024, 21(1), 33. https://doi.org/10.1186/s12986-024-00809-9 |
[56]
. Women in the highest quartile of intake of total dietary fiber, cereal fiber, vegetable fiber, and fruit fiber were 34.7%, 27.9%, 27.5%, and 20.2% less likely to be hyperuricemia [SUA concentration ≥ 6.0 mg/dL (356.9 µmol/L) in women] compared to those subjects in the lowest quartile of each fiber intake, respectively
[56] | Kim, J., Jung, D. Y., Lee, J-H., Kim, M. K., Kwon, H-S., Yim, H. W., Moon, S-J. Association between serum uric acid levels and dietary fiber intake in adults: the Korea national health and nutrition examination survey (KNHANES VII, 2016-2018). Nutr Metab (Lond). 2024, 21(1), 33. https://doi.org/10.1186/s12986-024-00809-9 |
[56]
.
Dietary glycemic load values, which reflect both quality and quantity of dietary carbohydrate intake, were negatively correlated with total fiber intake in Chinese adults in the China Health and Nutrition Survey 2009
[63] | Li, M., Cui, Z., Meng, S., Li, T., Kang, T., Ye, Q., Cao, M., Bi, Y., Meng, H. Associations between dietary glycemic index and glycemic load values and cardiometabolic risk factors in adults: findings from the China Health and Nutrition Survey. Nutrients. 2020, 13(1), 116. https://doi.org/10.3390/nu13010116 |
[63]
. Higher dietary glycemic load values, which reflect both quality and quantity of dietary carbohydrate intake, were significantly associated with an increased prevalence of hyperuricemia in Chinese adults in the China Health and Nutrition Survey 2009
[63] | Li, M., Cui, Z., Meng, S., Li, T., Kang, T., Ye, Q., Cao, M., Bi, Y., Meng, H. Associations between dietary glycemic index and glycemic load values and cardiometabolic risk factors in adults: findings from the China Health and Nutrition Survey. Nutrients. 2020, 13(1), 116. https://doi.org/10.3390/nu13010116 |
[63]
. These results suggest that an increased hyperuricemia risk may be partially due to the low intake of dietary fiber.
The exact mechanism for the beneficial effect of dietary fiber intake on gout remains largely unknown.
In an experimental model of gout in mice, which are made by injection of monosodium urate crystals into the knee joint, a high-fiber diet (5% cellulose + 10% pectin) controlled the inflammatory response to monosodium urate crystals by favoring the resolution of the inflammatory response
[64] | Vieira, A. T., Galväo, I., Macia, L. M., Sernaglia, É. M., Vinolo, M. A., Garcia, C. C., Tavares, L. P., Amaral, F. A., Sousa, L. P., Martins, F. S., Mackay, C. R., Teixeira, M. M. Dietary fiber and the short-chain fatty acid acetate promote resolution of neutrophilic inflammation in a model of gout in mice. J Leukoc Biol. 2017, 101(1), 275-284. https://doi.org/10.1189/jlb.3A1015-453RRR |
[64]
. In the same mouse model of gout, a pectin-rich fiber diet increased serum acetate concentrations and showed reduced joint destruction and decreased joint dysfunction (hypernociception) and interleukin-1β (IL-1β) production, compared with the cellulose diet
[64] | Vieira, A. T., Galväo, I., Macia, L. M., Sernaglia, É. M., Vinolo, M. A., Garcia, C. C., Tavares, L. P., Amaral, F. A., Sousa, L. P., Martins, F. S., Mackay, C. R., Teixeira, M. M. Dietary fiber and the short-chain fatty acid acetate promote resolution of neutrophilic inflammation in a model of gout in mice. J Leukoc Biol. 2017, 101(1), 275-284. https://doi.org/10.1189/jlb.3A1015-453RRR |
[64]
. Therefore, high intake of dietary fiber had a positive effect on the resolution of a gout flare in an experimental model of mice with gout
[64] | Vieira, A. T., Galväo, I., Macia, L. M., Sernaglia, É. M., Vinolo, M. A., Garcia, C. C., Tavares, L. P., Amaral, F. A., Sousa, L. P., Martins, F. S., Mackay, C. R., Teixeira, M. M. Dietary fiber and the short-chain fatty acid acetate promote resolution of neutrophilic inflammation in a model of gout in mice. J Leukoc Biol. 2017, 101(1), 275-284. https://doi.org/10.1189/jlb.3A1015-453RRR |
[64]
. High-fiber diet alleviated the inflammatory response induced by monosodium urate crystals through short chain fatty acids (SCFAs) production
[64] | Vieira, A. T., Galväo, I., Macia, L. M., Sernaglia, É. M., Vinolo, M. A., Garcia, C. C., Tavares, L. P., Amaral, F. A., Sousa, L. P., Martins, F. S., Mackay, C. R., Teixeira, M. M. Dietary fiber and the short-chain fatty acid acetate promote resolution of neutrophilic inflammation in a model of gout in mice. J Leukoc Biol. 2017, 101(1), 275-284. https://doi.org/10.1189/jlb.3A1015-453RRR |
[64]
.
Cao and Hu
[65] | Cao, S., Hu, Y. Interpretable machine learning framework to predict gout associated with dietary fiber and triglyceride-glucose index. Nutr Metab (Lond). 2024, 21, 25. https://doi.org/10.1186/s12986-024-00802-2 |
[65]
used the interpretable machine learning model based on SHapley Additive exPlanations (SHAP) to assess the contribution of dietary fiber in predicting gout using datasets from the NHANES (2005-2018). In the interpretable Light Gradient Boosting Machine (LGBM) model, increasing dietary fiber intake reduced the potential risk of gout. A large-scale prospective cohort study found that fiber intake was associated with a reduced risk of gout; that is to say, individuals in the second level (14.23 - < 17.43 g/day), the third level (17.43 - < 20.98 g/day), the highest level (≥ 20.98 g/day) of the fiber intake were 26%, 24%, and 28% less likely to be gout compared to those individuals in the lowest intake level (< 14.23 g/day) (p for Trend = 2.638 × 10
-9)
[33] | Hua, B., Dong, Z., Yang, Y., Liu, W., Chen, S., Chen, Y., Sun, X., Ye, D., Li, J., Mao, Y. Dietary carbohydrates, genetic susceptibility, and gout risk; a prospective cohort study in the UK. Nutrients. 2024, 16(17), 2883. https://doi.org/10.3390/nu16172883 |
[33]
.
Judging from the data of food composition
, it is important for Japanese people to eat seeds and nuts (pumpkin seeds, chia seeds, almonds, chestnuts, sunflower seeds, pine nuts, pistachio nuts, hazelnuts, peanuts, coconut), whole grains (high fiber-bran ready-to-eat cereals, shredded wheat ready-to-eat cereals, popcorn, bulgur, spelt, whole grain bread, oats, barley, rye), legumes (lima beans, navy beans, small white beans, yellow beans, green peas, adzuki beans, cranberry beans, adzuki beans, French beans, split peas, chickpeas, lentils, pinto beans), seaweed, mushrooms (wood ear, shiitake mushrooms, maitake mushrooms), potatoes (sweet potato, konjac, potato with skin), fruit (sapote or sapodilla, guava, nance, avocados, apples, raspberries, loganberries, blackberries, pear, kiwifruit, grapefruit, apple with skin, prunes, oranges, bananas,), and vegetables (artichokes, pumpkins, taro root (dasheen or yautia), brussels sprouts, tomatoes, broccoli, carrots, sweet corn, pears) to take in more dietary fiber to reach the DG established by the Ministry of Health, Labour and Welfare in Japan and recommended AIs established by the U.S. Department of Agriculture (USDA), the recommended intake by the Nordic Nutrition Recommendations 2012
[48] | Carlsen, H., Pajari, A-M. Dietary fiber – a scoping review for Nordic Nutrition Recommendations 2023. Food & Nutrition Research. 2023, 67, 9979. https://doi.org/10.29219/fnr.v67.9979 eCollection 2023 |
[48]
, and the German National Nutrition Monitoring (NEMONIT)
[49] | Gose, M., Krems, C., Heuer, T., Hoffmann, I. Trends in food consumption and nutrient intake in Germany between 2006 and 2012: results of the German National Nutrition Monitoring (NEMONIT). Br J Nutr. 2016, 115(8), 1498-1507. https://doi.org/10.1017/S0007114516000544 |
[49]
, the European Food Safety Authority
[50] | European Food Safety Authority. Scientific opinion on dietary reference values for carbohydrates and dietary fibre 1EFSA panel on dietetic products, nutrition, and allergies (NDA). EFSA J. 2010, 8, 1462. |
[50]
, and the Joint WHO/FAO Expert Consultation
[46] | Nishida, C., Uauy, R., Kumanyika, S., & Shetty, P. The joint WHO/FAO expert consultation on diet, nutrition and the prevention of chronic diseases: process, product and policy implications. Public Health Nutr. 2004, 7(1A), 245-250. https://doi.org/10.1079/phn2003592 |
[46]
. Though the daily dietary fiber intake was positively correlated with the number of gout patients in the adult population (aged ≥ 20 years) in 2004-2022, it seems that Japanese adult population (aged ≥ 20 years) need to take in more dietary fiber. Increase in intake of fiber-rich foods (e.g., whole grains, legumes, seeds and nuts, fruit, vegetables) in Japanese people seems to be important for the prevention of gout.
Other article will describe the importance of intake of dietary fiber for the prevention of hyperuricemia and/or gout in Japanese people in detail including the role of dietary fiber on gut microbiota.
Ratio of Energy Intake from Carbohydrate in Total Energy Intake
The mean ratio of energy intake from carbohydrate in total energy intake (Carbohydrate/Energy) of Japanese people in 2022 was lower compared to that in 1975, 1980, 1986, 1989, 1992, 1995, 1998, 2001, 2004, 2007, 2010, 2013, 2016, and 2019 (1975: 63.1%; 1980: 61.5%; 1986: 60.3%; 1989: 58.7%; 1992: 58.9%; 1995: 57.8%; 1998: 57.8%; 2001: 59.7%; 2004: 59.7%; 2007: 59.3%; 2010: 59.4%; 2013: 58.9%; 2016: 57.8%; 2019: 56.3%; 2022: 55.8%). The Carbohydrate/Energy did not show a significant correlation with the number of gout patients in 1986-2019 (r= -0.358, p= 0.253) and in 1986-2022 (r= -0.519, p= 0.0690).
The Carbohydrate/Energy of Japanese adult population (aged ≥ 20 years) in 2022 was lower compared to that in 2019 (2019: 56.4%; 2022: 55.9%). The Carbohydrate/Energy was negatively correlated with the number of gout patients in the adult population (aged ≥ 20 years) in 2004-2019 (r= -0.932, p= 0.00687) and in 2004-2022 (r= -0.967, p= 0.000377).
The Carbohydrate/Energy of Japanese adult men (aged ≥ 20 years) and adult women (aged ≥ 20 years) in 2022 were lower compared to those in 2019, respectively (men: 2019: 57.8%; 2022: 57.0%, women: 2019: 55.3%; 2022: 54.9%). The Carbohydrate/Energy was negatively correlated with the number of gout patients in adult men (aged ≥ 20 years) in 2004-2019 (r= -0.954, p=0.00314) and in 2004-2022 (r= -0.967, p= 0.000383). The Carbohydrate/Energy did not show a significant correlation with the number of gout patients in adult women (aged ≥ 20 years) in 2004-2019 (r= 0.541, p= 0.268) and in 2004-2022 (r= 0.316, p= 0.490). This result suggests that the correlation of the Carbohydrate/Energy with the number of gout patients varies with gender.
The results of a recently published article are presented below. In a cross-sectional study in 7886 Chinese adults who participated in the China Health and Nutrition Survey 2009, substituting 5% of energy intake from the total protein for carbohydrates was associated with increase in SUA concentrations
[67] | Meng, S., Cui, Z., Li, M., Li, T., Wu, F., Kang, T., Meng, H. Associations between dietary animal and plant protein intake and cardiometabolic risk factors- a cross-sectional study in China Health and Nutrition Survey. Nutrients. 2021, 13(2), 336. https://doi.org/10.3390/nu13020336 |
[67]
.
The Carbohydrate/Energy of Japanese men (aged ≥ 15 year) and women (aged ≥ 15 year) in 2022 were 55.1-59.2% of energy and 52.3-58.2% of energy, respectively, and were within the Tentative Dietary Goal for Preventing Lifestyle-related Diseases (DG) established by the Ministry of Health, Labour and Welfare in Japan [ men (aged ≥ 1 year): 50-65% of energy; women (aged ≥ 1 year): 50-65% of energy]
or the Acceptable Macronutrient Distribution Ranges (AMDRs) set by the Institute of Medicine of the National Academy of Sciences in the U.S.
[27] | Institute of Medicine of the National Academy of Sciences. Food and Nutrition Board. Dietary Reference Intakes: The essential guide to nutrient requirements. Washington, D.C. The National Academy Press. Available from: https://www.nap.edu/catalog/11537.html (accessed 14 October 2021). |
[27]
. The Institute of Medicine of the National Academy of Sciences in the U.S. has determined that the AMDRs, which is defined as a range of intakes for a particular energy source that is associated with reduced risk of chronic disease while providing adequate intakes of essential nutrients, for carbohydrates both adults (aged ≥ 19 years) and children (aged 1-18 years) is 45-65 percent of total calories
[27] | Institute of Medicine of the National Academy of Sciences. Food and Nutrition Board. Dietary Reference Intakes: The essential guide to nutrient requirements. Washington, D.C. The National Academy Press. Available from: https://www.nap.edu/catalog/11537.html (accessed 14 October 2021). |
[27]
. Furthermore, the Joint WHO/FAO Expert Consultation
[46] | Nishida, C., Uauy, R., Kumanyika, S., & Shetty, P. The joint WHO/FAO expert consultation on diet, nutrition and the prevention of chronic diseases: process, product and policy implications. Public Health Nutr. 2004, 7(1A), 245-250. https://doi.org/10.1079/phn2003592 |
[46]
has stated that the recommended the Carbohydrate/Energy is 15-75% of total energy (calories). Intake of fiber-rich foods (e.g., whole grains, legumes, seeds and nuts, fruit, vegetables) seems to be important for the prevention of gout.
3.3.3. Proteins
Total Protein
The daily total protein intake of Japanese people in 2022 was lower compared to that in 1975, 1986, 1989, 1992, 1995, 1998, 2001, and 2019 and was higher compared to that in 1960, 2004, 2007, 2010, 2013, and 2016 and was the same as that in 1965 (1960: 69.7 g/day; 1965: 71.3 g/day; 1975: 80.0 g/day; 1986: 78.9 g/day; 1989: 80.2 g/day; 1992: 80.1 g/day; 1995: 81.5 g/day; 1998: 79.2 g/day; 2001: 73.4 g/day; 2004: 70.8 g/day; 2007: 69.8 g/day; 2010: 67.3 g/day; 2013: 68.9 g/day; 2016: 68.5 g/day; 2019: 71.4 g/day; 2022: 71.3 g/day). The daily total protein intake was negatively correlated with the number of gout patients in 1986-2019 (r= -0.887, p= 0.000118) and in 1986-2022 (r= -0.855, p= 0.000197).
The daily total protein intake of Japanese adult population (aged ≥ 20 years) in 2022 was lower compared to that in 2019 (2019: 72.2 g/day; 2022: 71.9 g/day). The daily intake of total protein did not show a significant correlation with the number of gout patients in the adult population (aged ≥ 20 years) in 2004-2019 (r= 0.159, p= 0.764), and in 2004-2022 (r= 0.356, p= 0.433).
The daily total protein intake of Japanese adult men (aged ≥ 20 years) and adult women (aged ≥ 20 years) in 2022 were lower compared to those in 2019, respectively (men: 2019: 78.8 g/day; 2022: 78.5 g/day, women: 2019: 66.4 g/day; 2022: 66.2 g/day). The daily intake of total protein did not show a significant correlation with the number of gout patients in adult men (aged ≥ 20 years) in 2004-2019 (r= 0.077, p= 0.885) and in 2004-2022 (r= 0.268, p= 0.561). The daily intake of total protein did not show a significant correlation with the number of gout patients in adult women (aged ≥ 20 years) in 2004-2019 (r= 0.527, p= 0.283) and in 2004-2022 (r= 0.537, p= 0.214).
The mean daily total protein intake of Japanese men (aged ≥ 15 years) and women (aged ≥ 15 years) in 2022 were 76.5-90.8 g/day and 60.2-70.4 g/day, respectively, and exceeded the recommended dietary allowances (RDAs) [men (aged ≥ 15 years): 60-65 g/day; women (aged ≥ 15 years): 50-55 g/day]
. The RDAs for protein in the U.S. adults (aged ≥ 19 years) established by the Institutes of Medicine is 0.8 g/kg body weight for the reference body weight
[27] | Institute of Medicine of the National Academy of Sciences. Food and Nutrition Board. Dietary Reference Intakes: The essential guide to nutrient requirements. Washington, D.C. The National Academy Press. Available from: https://www.nap.edu/catalog/11537.html (accessed 14 October 2021). |
[68] | Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes: Recommended Dietary Allowances and Adequate Intakes, Total Water and Macronutrients. (2011) Washington, D.C. The National Academy Press. Available from: https://www.ncbi.nlm.nih.gov/books/NBK56068/table/summarytables.t4/?report=objectonly (accessed 18 October 2024). |
[27, 68]
. In healthy adult men and women, protein intake should not exceed the World Health Organization (WHO) recommendation (0.83 g/ kg body weight/day for adults
[69] | The World Health Organization, Food and Agriculture Organization, and United Nations University. Protein and amino acid requirements in human nutrition. Tech Rep Ser. Geneva, Switzerland: WHO Press; 2007, pp. 935. |
[69]
). UK Gout Society
has stated that gout patients need about 1 g of protein per kg of body weight, unless they on a protein restricted diet (e.g., some people with kidney disease may need to restrict protein intake). The Ministry of Health, Labour and Welfare in Japan
has not set a Tolerable Upper Intake Levels (ULs) for healthy individuals because there are insufficient reports of clear scientific evidence for health problems due to excessive daily intake of protein. However, excessive intake of protein can reduce renal function. A meta-analysis concluded that higher protein intake (≥ 20% but < 35% of energy or ≥ 10% higher than a comparison intake) within the range of recommended intakes for protein was consistent with normal renal function in healthy individuals in the short term (and did not reduce renal function)
[71] | Van Elswyk, M. E., Weatherford, C. A., McNeill, S. H. A systematic review of renal health in healthy individuals associated with protein intake above the US Recommended Allowance in randomized controlled trials and observational studies. Adv Nutr. 2018, 9(4), 404-418. https://doi.org/10.1093/advances/nmy026 |
[71]
. In healthy adults, consuming a higher-protein diet did not cause changes in kidney function compared with lower- or normal-protein diets
[72] | Devries, M. C., Sithamparapillai, A., Brimble, K. S., Banfield, L., Morton, R. W., Phillips, S. M. Changes in kidney function do not differ between healthy adults consuming higher- compared with lower- or normal-protein diets: A systematic review and meta-analysis. J Nutr. 2018, 148(11), 1760-1775. https://doi.org/10.1093/jn/nxy197 |
[72]
.
The results of a recently published article are presented below. A cross-sectional study using US NHANES (2017-2018) data showed that no statistical difference was found about the associations of dietary protein intake with SUA concentrations
[31] | Yao, J., Zhang, Y., Zhao, J., Lin, Y-P., Lu, Q-Y., Fan, G-J. Cor relation of obesity, dietary patterns, and blood pressure with uric acid: data from the NHANES 2017-2018. BMC Endocr Disord. 2022, 22(1), 196. https://doi.org/10.1186/s12902-022-01112-5 |
[31]
. A cross-sectional study from China showed that every 10 g increase in energy-adjusted protein intakes caused a 17% increase in hyperuricemia risk
[32] | Zhang, M., Ye, C., Wang, R., Zhang, Z., Huang, X., Halimulati, M., Sun, M., Ma, Y., Zhang, Z. Association between dietary acid load and hyperuricemia in Chinese adults: Analysis of the China Health and Nutrition Survey (2009). Nutrients. 2023, 15(8), 1806. https://doi.org/10.3390/nu15081806 |
[32]
. In a 6-year follow-up study of 1621 community-dwelling Chinese participants (aged 50-70 years) without hyperuricemia [SUA concentration > 420.0 µmol/L in men and > 360.0 µmol/L in women], plasma cysteine, glutamine, phenylalanine, threonine, and long-chain acylcarnitines were positively associated with incident hyperuricemia
[73] | Wang, F., Sun, L., Zong, G., Gao, X., Zhang, H., Xiong, Q., Huo, S., Niu, Z., Sun, Q., Zeng, R., Li, X. Associations of amino acid and acylcarnitine profiles with incident hyperuricemia in middle-aged and older Chinese individuals. Arthritis Care Res (Hoboken). 2020, 72(9), 1305-1314. https://doi.org/10.1002/acr.24013 |
[73]
. Wang et al.
[73] | Wang, F., Sun, L., Zong, G., Gao, X., Zhang, H., Xiong, Q., Huo, S., Niu, Z., Sun, Q., Zeng, R., Li, X. Associations of amino acid and acylcarnitine profiles with incident hyperuricemia in middle-aged and older Chinese individuals. Arthritis Care Res (Hoboken). 2020, 72(9), 1305-1314. https://doi.org/10.1002/acr.24013 |
[73]
have stated that the levels of these metabolites may be partially driven by intakes of meat and soy products that are associated with hyperuricemia.
In a prospective cohort study in a Chinese population, higher intake of total protein, protein from poultry, protein from seafood (fish and shellfish) was associated with increased gout risk, respectively, whereas higher intake of protein from soy foods and protein from nonsoy legumes was associated with decreased gout risk, respectively
[74] | Teng, G. G., Pan, A., Yuan, J. M., Koh, W. P. Food sources of protein and risk of incident gout in the Singapore Chinese Health Study. Arthritis Rheumatol. 2015, 67(7), 1933-1942. https://doi.org/10.1002/art.39115 |
[74]
. Protein intake from red meat, eggs, dairy products, grain products, or nuts and seeds had no association with gout risk, respectively
[74] | Teng, G. G., Pan, A., Yuan, J. M., Koh, W. P. Food sources of protein and risk of incident gout in the Singapore Chinese Health Study. Arthritis Rheumatol. 2015, 67(7), 1933-1942. https://doi.org/10.1002/art.39115 |
[74]
.
Animal Protein
The daily animal protein intake of Japanese people in 2022 was higher compared to that in 1960 1965, 1975, 1986, 2001, 2004, 2007, 2010, 2013, 2016, and 2019 and was lower compared to that in 1989, 1992, 1995, and 1998 (1960: 24.7 g/day; 1965: 28.5 g/day; 1975: 38.9 g/day; 1986: 40.1 g/day; 1989: 42.4 g/day; 1992: 42.5 g/day; 1995: 44.4 g/day; 1998: 42.8 g/day; 2001: 39.9 g/day; 2004: 38.0 g/day; 2007: 38.0 g/day; 2010: 36.0 g/day; 2013: 37.2 g/day; 2016: 37.4 g/day; 2019: 40.1 g/day; 2022: 40.4 g/day). The daily intake of animal protein was negatively correlated with the number of gout patients in 1986-2019 (r= -0.709, p= 0.00985) and in 1986-2022 (r= -0.612, p= 0.0262).
The daily animal protein intake of Japanese adult population (aged ≥ 20 years) in 2022 was higher compared to that in 2019 (2019: 40.1 g/day; 2022: 40.4 g/day). The daily intake of animal protein did not show a significant correlation with the number of gout patients in the adult population (aged ≥ 20 years) in 2004-2019 (r= 0.541, p= 0.267) and in 2004-2022 (r= 0.717, p= 0.0698).
The daily animal protein intake of Japanese adult men (aged ≥ 20 years) and adult women (aged ≥ 20 years) in 2022 were higher compared to those in 2019, respectively (men: 2019: 44.3 g/day; 2022: 44.6 g/day, women: 2019: 36.4 g/day; 2022: 36.7 g/day). The daily intake of animal protein did not show a significant correlation with the number of gout patients in adult men (aged ≥ 20 years) in 2004-2019 (r= 0.451, p= 0.369) and in 2004-2022 (r= 0.649, p= 0.115). The daily intake of animal protein did not show a significant correlation with the number of gout patients in adult women (aged ≥ 20 years) in 2004-2019 (r= 0.154, p= 0.771) and in 2004-2022 (r= 0.211, p= 0.649).
The results of a recently published article are presented below. A cross-sectional study from China showed that every 10 g increase in energy-adjusted animal protein intakes caused a 18% increase in hyperuricemia risk
[32] | Zhang, M., Ye, C., Wang, R., Zhang, Z., Huang, X., Halimulati, M., Sun, M., Ma, Y., Zhang, Z. Association between dietary acid load and hyperuricemia in Chinese adults: Analysis of the China Health and Nutrition Survey (2009). Nutrients. 2023, 15(8), 1806. https://doi.org/10.3390/nu15081806 |
[32]
. In a cross-sectional study in 7886 Chinese adults who participated in the China Health and Nutrition Survey 2009, dietary animal protein (red meat 48.8%; egg 24.7%; fish and seafood 15.5%; white meat 7.7%; offal 1.8%; dairy 1.5%) intake was associated with increased SUA concentrations
[67] | Meng, S., Cui, Z., Li, M., Li, T., Wu, F., Kang, T., Meng, H. Associations between dietary animal and plant protein intake and cardiometabolic risk factors- a cross-sectional study in China Health and Nutrition Survey. Nutrients. 2021, 13(2), 336. https://doi.org/10.3390/nu13020336 |
[67]
. The potential underlying mechanisms of the positive associations between animal protein intake and SUA levels may be attributable to the effects of amino acids on purine synthesis and/or the exogenous purine from foods enriched in animal protein
[75] | Juraschek, S. P., McAdams-Demarco, M., Gelber, A. C., Sacks, F. M., Appel, L. J., White, K. J., Miller, E. R. Effects of lowering glycemic index of dietary carbohydrate on plasma uric acid levels: The OmniCarb Randomized Clinical Trial. Arthritis Rheumatol. 2016, 68(5), 1281-1289. https://doi.org/10.1002/art.39527 |
[75]
. In a 3-phase randomized, crossover metabolic study in healthy subjects (aged 18-70 years), consuming animal protein was associated with increased SUA concentrations and amount of urinary UA excretion
[76] | Tracy, C. R., Best, S., Bagrodia, A., Poindexter, J. R., Adams-Huet, B., Sakhaee, K., Maalouf, N., Pak, C. Y. C., Pearle, M. S. Animal protein and the risk of kidney stones: a comparative metabolic study of animal protein sources. J Urol. 2014, 192(1), 137-141. https://doi.org/10.1016/j.juro.2014.01.093 |
[76]
.
In a clinical trial, animal sources of protein (e.g., casein, lactalbumin
[77] | Dalbeth, N., Wong, S., Gamble, G. D., Horne, A., Mason, B., Pool, B., Fairbanks, L., McQueen, F. M., Cornish, J., Reid, I. R., Palmano, K. Acute effect of milk on serum urate concentrations: a randomized controlled crossover trial. Ann Rheum Dis. 2010, 69(9), 1677-1682. https://doi.org/10.1136/ard.2009.124230 |
[78] | Garrel, D. R., Verdy, M., PetitClerc, C., Martin, C., Brulé, D., Hamet, P. Milk-and soy-protein ingestion; Acute effect on serum uric acid concentration. Am J Clin Nutr. 1991, 53(3), 665-669. https://doi.org/10.1093/ajcn/53.3.665 |
[77, 78]
) decreased SUA concentrations. Ingestion of milk (casein and lactalbumin) has been shown to decrease SUA levels in healthy subjects via the uricosuric effect of these proteins
[78] | Garrel, D. R., Verdy, M., PetitClerc, C., Martin, C., Brulé, D., Hamet, P. Milk-and soy-protein ingestion; Acute effect on serum uric acid concentration. Am J Clin Nutr. 1991, 53(3), 665-669. https://doi.org/10.1093/ajcn/53.3.665 |
[78]
. An increase in intake of milk (particularly a low-fat milk) and cheese seems to be important for the prevention of gout through a decrease in SUA concentrations.
Vegetable Protein
The vegetable protein is from grains, potatoes, legumes, seeds, nuts, fruit, vegetables, mushrooms, and seaweed. The daily vegetable protein intake of Japanese people in 2022 was lower compared to that in 1960, 1965, 1975, 1986, 1989, 1992, 1995, 1998, 2001, 2004, 2007, 2010, 2013, 2016, and 2019 (1960: 45.0 g/day; 1965: 42.8 g/day; 1975: 41.1 g/day; 1986: 38.8 g/day; 1989: 37.8 g/day; 1992: 37.6 g/day; 1995: 37.1 g/day; 1998: 36.4 g/day; 2001: 33.5 g/day; 2004: 32.8 g/day; 2007: 31.8 g/day; 2010: 31.3 g/day; 2013: 31.7 g/day; 2016: 31.1 g/day; 2019: 31.3 g/day; 2022: 30.9 g/day). The daily vegetable protein intake was negatively correlated with the number of gout patients in 1986-2019 (r= -0.960, p= 0.000000715) and in 1986-2022 (r= -0.956, p= 0.000000330).
The daily vegetable protein intake of Japanese adult population (aged ≥ 20 years) in 2022 was lower compared to that in 2019 (2019: 32.1 g/day; 2022: 31.5 g/day). The daily intake of vegetable protein did not show a significant correlation with the number of gout patients in the adult population (aged ≥ 20 years) in 2004-2019 (r= -0.507, p= 0.304) and in 2004-2022 (r= -0.616, p= 0.141).
The daily vegetable protein intake of Japanese adult men (aged ≥ 20 years) and adult women (aged ≥ 20 years) in 2022 were lower compared to those in 2019, respectively (men: 2019: 34.5 g/day; 2022: 33.9 g/day, women: 2019: 30.0 g/day; 2022: 29.5 g/day). The daily intake of vegetable protein tended to be negatively correlated with the number of gout patients in adult men (aged ≥ 20 years) in 2004-2019 (r= -0.788, p= 0.0628). The daily intake of vegetable protein was negatively correlated with the number of gout patients in adult men (aged ≥ 20 years) in 2004-2022 (r= -0.864, p= 0.0121). The daily intake of vegetable protein was positively correlated with the number of gout patients in adult women (aged ≥ 20 years) in 2004-2019 (r= 0.865, p= 0.0262). The daily intake of vegetable protein did not show a significant correlation with the number of gout patients in adult women (aged ≥ 20 years) in 2004-2022 (r= 0.686, p= 0.0887). This result suggests that the correlation of daily vegetable protein intake with the number of gout patients tends to vary with gender.
The results of a recently published article are presented below. In a cross-sectional study in 7886 Chinese adults who participated in the China Health and Nutrition Survey 2009, dietary plant protein (grains 68.9%; legumes 13.8%; fruits and vegetables 13.1%; tubers 2.0%; nuts 1.4%; fungi and algae 0.7%) intake was associated with decreased SUA concentrations in the unadjusted models, while that was not significantly associated with SUA concentrations in the fully-adjusted models
[67] | Meng, S., Cui, Z., Li, M., Li, T., Wu, F., Kang, T., Meng, H. Associations between dietary animal and plant protein intake and cardiometabolic risk factors- a cross-sectional study in China Health and Nutrition Survey. Nutrients. 2021, 13(2), 336. https://doi.org/10.3390/nu13020336 |
[67]
. A cross-sectional study from China showed that every 10 g increase in energy-adjusted plant-derived protein intakes caused a 10% decrease in hyperuricemia risk
[32] | Zhang, M., Ye, C., Wang, R., Zhang, Z., Huang, X., Halimulati, M., Sun, M., Ma, Y., Zhang, Z. Association between dietary acid load and hyperuricemia in Chinese adults: Analysis of the China Health and Nutrition Survey (2009). Nutrients. 2023, 15(8), 1806. https://doi.org/10.3390/nu15081806 |
[32]
.
Vegetable sources of protein (e.g., wheat gluten
[79] | Jenkins, D. J., Kendall, C. W., Vidgen, E., Augustin, L. S., van Erk, M., Geelen, A., Parker, T., Faulkner, D., Vuksan, V., Josse, R. G., Leiter, L. A., Connelly, P. W. High-protein diets in hyperlipidemia: effect of wheat gluten on serum lipids, uric acid, and renal function. Am J Clin Nutr. 2001, 74(1), 57-63. https://doi.org/10.1093/ajcn/74.1.57 |
[79]
, rice endosperm protein
[80] | Hosojima, M., Kaseda, R., Kondo, H., Fujii, M., Kubota, M., Watanabe, R., Tanabe, N., Kadowaki, M., Suzuki, Y., Saito, A. Beneficial effects of rice endosperm protein intake in Japanese men with risk factors for metabolic syndrome: a randomized, crossover clinical trial. BMC Nutr. 2016, 2, 25. https://doi.org/10.1186/s40795-016-0065-7 |
[80]
) decreased SUA concentrations. An increase in intake of wheat gluten and rice endosperm protein seems to be important for the prevention of gout through a decrease in SUA concentrations. Intake of casein, lactalbumin, wheat gluten, and rice endosperm protein seem to be important for the prevention of gout through a decrease in SUA concentrations.
Ratio of Energy Intake from Protein in Total Energy Intake
The mean ratio of energy intake from protein in total energy intake (Protein/Energy) of Japanese people in 2022 was higher compared to that in 1975, 1980, 2007, 2010, 2013, and 2016 was lower compared to that in 1986, 1989, 1992, 1995, and 1998 and was about the same as that in 2002, 2005, and 2019 (1975: 14.6%; 1980: 14.9%; 1986: 15.2%; 1989: 15.6%; 1992: 15.6%; 1995: 16.1%; 1998: 16.1%; 2002: 15.1%; 2005: 15.1%; 2007: 14.8%; 2010: 14.7%; 2013: 14.8%; 2016: 14.8%; 2019: 15.1%; 2022: 15.1%). The Protein/Energy was negatively correlated with the number of gout patients i in 1986-2019 (r= -0.661, p= 0.0192) and in 1986-2022 (r= -0.637, p= 0.0193).
The Protein/Energy of Japanese adult population (aged ≥ 20 years) in 2022 was the same as that in 2019 (2019: 15.2% of energy; 2022: 15.2% of energy). The Protein/Energy did not show a significant correlation with the number of gout patients in the adult population (aged ≥ 20 years) in 2004-2019 (r= 0.458, p= 0.361) and in 2004-2022 (r= 0.646, p= 0.117).
The Protein/Energy of Japanese adult men (aged ≥ 20 years) and adult women (aged ≥ 20 years) in 2022 were higher compared to those in 2019, respectively (men: 2019: 14.8% of energy; 2022: 14.9% of energy, women: 2019, 15.5% of energy; 2022: 15.6% of energy). The Protein/Energy did not show a significant correlation with the number of gout patients in adult men (aged ≥ 20 years) in 2004-2019 (r= 0.470, p= 0.347) and in 2004-2022 (r= 0.681, p= 0.092). The Protein/Energy did not show a significant correlation with the number of gout patients in adult women (aged ≥ 20 years) in 2004-2019 (r= 0.275, p=0.598) and in 2004-2022 (r= 0.299, p= 0.514).
The Protein/Energy of Japanese men (aged ≥ 15 year) and women (aged ≥ 15 year) in 2022 were 14.7-15.1% of energy and 14.7-16.0% of energy, respectively, and were within the Tentative Dietary Goal for Preventing Lifestyle-related Diseases (DG) established by the Ministry of Health, Labour and Welfare in Japan [men (≥ 15 year): 13-20% of energy; women (aged ≥ 15 year): 13-20% of energy]
. The Institute of Medicine of the National Academy of Sciences in the U.S. has determined that the Acceptable Macronutrient Distribution Ranges (AMDRs) for total protein at 10-35 percent of total calories for adults (aged ≥ 19 years) and at 10-30 percent of total calories for children (aged 4-18 years) and 5-20 percent of total calories for children (aged 1-3 years)
[27] | Institute of Medicine of the National Academy of Sciences. Food and Nutrition Board. Dietary Reference Intakes: The essential guide to nutrient requirements. Washington, D.C. The National Academy Press. Available from: https://www.nap.edu/catalog/11537.html (accessed 14 October 2021). |
[27]
. The Joint WHO/FAO Expert Consultation
[46] | Nishida, C., Uauy, R., Kumanyika, S., & Shetty, P. The joint WHO/FAO expert consultation on diet, nutrition and the prevention of chronic diseases: process, product and policy implications. Public Health Nutr. 2004, 7(1A), 245-250. https://doi.org/10.1079/phn2003592 |
[46]
has stated that the recommended the Protein/Energy is 10-15% of total energy (calories).
The population-based cohort study in a Chinese adult population (aged 45-74 years) revealed that the daily total protein intake of subjects with gout was significantly higher than that of subjects without gout (subjects with gout: 15.4±2.5% energy; subjects without gout: 15.2±2.4% energy) and the daily soy protein intake of subjects with gout tended to decrease compared to that of subjects without gout (subjects with gout: 1.47±0.99% energy; subjects without gout: 1.50±1.01% energy)
[74] | Teng, G. G., Pan, A., Yuan, J. M., Koh, W. P. Food sources of protein and risk of incident gout in the Singapore Chinese Health Study. Arthritis Rheumatol. 2015, 67(7), 1933-1942. https://doi.org/10.1002/art.39115 |
[74]
. The daily total protein intake (the mean ratio of energy intake from protein in total energy intake) of Japanese adult population (aged ≥ 20 years) was 15.2% of energy. The daily total protein intake of Japanese adult population (aged ≥ 20 years) was as same as that of Chinese adult population without gout (aged 45-74 years).
The ingestion of milk proteins (casein, lactalbumin) has been shown to exert a uricosuric effect in healthy subjects
[78] | Garrel, D. R., Verdy, M., PetitClerc, C., Martin, C., Brulé, D., Hamet, P. Milk-and soy-protein ingestion; Acute effect on serum uric acid concentration. Am J Clin Nutr. 1991, 53(3), 665-669. https://doi.org/10.1093/ajcn/53.3.665 |
[81] | Moi, J. H., Sriranganathan, M. K., Falzon, I., Edwards, C. J., van der Heijde, D. M., Buchbinder, R. Lifestyle interventions for the treatment of gout: a summary of 2 Cochrane systematic reviews. J Rheumatol. 2014, Suppl 92, 26-32. https://doi.org/10.3899/jrheum.140459 |
[78, 81]
. The Protein/Energy seems to be appropriate or it seems better to increase it slightly. Increase in intake of animal protein from low-fat dairy products (e.g., casein, lactalbumin) and vegetable sources of protein (e.g., wheat gluten, rice endosperm protein) in Japanese people seems to be important for the prevention of gout.
3.3.4. Fats
Total Fat
The daily total fat intake of Japanese people in 2022 was higher compared to that in 1960, 1965, 1975, 1986, 1989, 1992, 1995, 1998, 2001, 2004, 2007, 2010, 2013, 2016, and 2019 (1960: 24.7 g/day; 1965: 36.0 g/day; 1975: 52.0 g/day; 1986: 56.6 g/day; 1989: 58.9 g/day; 1992: 58.4 g/day; 1995: 59.9 g/day; 1998: 57.9 g/day; 2001: 55.3 g/day; 2004: 54.1 g/day; 2007: 55.1 g/day; 2010: 53.7 g/day; 2013: 55.0 g/day; 2016: 57.2 g/day; 2019 61.3 g/day; 2022: 61.7 g/day). The daily intake of total fat did not show a significant correlation with the number of gout patients in 1986-2019 (r= -0.210, p= 0.512) and in 1986-2022 (r= 0.0549, p= 0.859).
The daily total fat intake of Japanese adult population (aged ≥ 20 years) in 2022 was higher compared to that in 2019 (2019: 61.2 g/day; 2022: 61.5 g/day). The daily intake of total fat was positively correlated with the number of gout patients in the adult population (aged ≥ 20 years) in 2004-2019 (r= 0.904, p= 0.0133) and in 2004-2022 (r= 0.941, p= 0.00159).
The daily total fat intake of Japanese adult men (aged ≥ 20 years) and adult women (aged ≥ 20 years) in 2022 were higher compared to those in 2019, respectively (men: 2019: 66.3 g/day; 2022: 66.7 g/day, women: 2019: 56.7 g/day; 2022: 57.0 g/day). The daily intake of total fat was positively correlated with the number of gout patients in adult men (aged ≥ 20 years) in 2004-2019 (r= 0.912, p= 0.0113) and in 2004-2022 (r= 0.944, p= 0.0014). The daily intake of total fat did not show a significant correlation with the number of gout patients in adult women (aged ≥ 20 years) in 2004-2019 (r= -0.437, p= 0.387) and in 2004-2022 (r= -0.250, p= 0.588). This result suggests that the correlation of daily total fat intake with the number of gout patients varies with gender and is stronger in adult men than in adult women.
The daily total fat intake of Japanese men (aged ≥ 15 years) in 2022 was higher compared to that in 2016 and was about the same as that in 2019 (2016: 52.7-76.6 g/day; 2019: 56.4-84.4 g/day; 2022: 61.1-84.3 g/day). The daily total fat intake of Japanese women (aged ≥ 20 years) in 2022 was higher compared to that in 2016 and was about the same as that in 2019 (2016: 46.4-55.9 g/day; 2019: 51.3-59.1 g/day; 2022: 52.4-58.9 g/day). The Ministry of Health, Labour and Welfare in Japan
has not set the Recommended Dietary Allowances (RDAs) for the daily total fat intake in Japanese people. The Estimated Average Requirement (EAR), Recommended Dietary Allowances (RDAs), the Adequate Intakes (AIs), and the Tolerable Upper Intake Levels (ULs) for total fat for individuals aged 1 year and older in the U.S. established by the Institutes of Medicine has not been set
[27] | Institute of Medicine of the National Academy of Sciences. Food and Nutrition Board. Dietary Reference Intakes: The essential guide to nutrient requirements. Washington, D.C. The National Academy Press. Available from: https://www.nap.edu/catalog/11537.html (accessed 14 October 2021). |
[68] | Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes: Recommended Dietary Allowances and Adequate Intakes, Total Water and Macronutrients. (2011) Washington, D.C. The National Academy Press. Available from: https://www.ncbi.nlm.nih.gov/books/NBK56068/table/summarytables.t4/?report=objectonly (accessed 18 October 2024). |
[27, 68]
.
In epidemiological studies, increased intake of fat was associated with increased SUA concentrations
[51] | Zykova, S. N., Storhaug, H. M., Toft, I., Chadban, S. J., Jenssen, T. G., White, S. L. Cross-sectional analysis of nutrition and serum uric acid in two Caucasian cohorts: the AusDiab Study and the Tromsø study. Nutr J. 2015, 14, 49. https://doi.org/10.1186/s12937-015-0032-1 |
[51]
.
The results of a recently published article are presented below. A cross-sectional study using US NHANES (2017-2018) data showed that no statistical difference was found about the associations of dietary total fat intake with SUA concentrations
[31] | Yao, J., Zhang, Y., Zhao, J., Lin, Y-P., Lu, Q-Y., Fan, G-J. Cor relation of obesity, dietary patterns, and blood pressure with uric acid: data from the NHANES 2017-2018. BMC Endocr Disord. 2022, 22(1), 196. https://doi.org/10.1186/s12902-022-01112-5 |
[31]
. A cross-sectional study from China showed that every 10 g increase in energy-adjusted fat intakes caused a 10% increase in hyperuricemia risk
[32] | Zhang, M., Ye, C., Wang, R., Zhang, Z., Huang, X., Halimulati, M., Sun, M., Ma, Y., Zhang, Z. Association between dietary acid load and hyperuricemia in Chinese adults: Analysis of the China Health and Nutrition Survey (2009). Nutrients. 2023, 15(8), 1806. https://doi.org/10.3390/nu15081806 |
[32]
.
Animal Fat
The daily animal fat intake of Japanese people in 2022 was higher compared to that in 1972, 1975, 1980, 1986, 1989, 1992, 1995, 1998, 2001, 2004, 2007, 2010, 2013, and 2016 and was lower compared to that in 2019 (1972: 27.0 g/day; 1975: 27.4 g/day; 1980: 26.9 g/day; 1986: 27.9 g/day; 1989: 28.3 g/day; 1992: 28.5 g/day; 1995: 29.8 g/day; 1998: 29.2 g/day; 2001: 27.2 g/day; 2004: 26.8 g/day; 2007: 27.7 g/day; 2010: 27.1 g/day; 2013: 28.1 g/day; 2016: 29.1 g/day; 2019: 32.4 g/day; 2022: 32.3 g/day). The daily animal fat intake did not show a significant correlation with the number of gout patients in 1986-2019 (r= 0.242, p= 0.339) and in 1986-2022 (r= 0.433, p= 0.139).
The daily animal fat intake of Japanese adult population (aged ≥ 20 years) in 2022 was lower compared to that in 2019 (2019: 31.9 g/day; 2022: 31.7 g/day). The daily animal fat intake was positively correlated with the number of gout patients in the adult population (aged ≥ 20 years) in 2004-2019 (r= 0.921, p= 0.00905) and in 2004-2022 (r= 0.949, p= 0.00109).
The daily animal fat intake of Japanese adult men (aged ≥ 20 years) in 2022 was lower compared to that in 2019 (2019: 35.2 g/day; 2022: 34.8 g/day). The daily animal fat intake of Japanese adult women (aged ≥ 20 years) in 2022 was higher compared to that in 2019 (2019: 28.9 g/day; 2022: 29.0 g/day). The daily animal fat intake was positively correlated with the number of gout patients in adult men (aged ≥ 20 years) in 2004-2019 (r= 0.921, p= 0.00919) and in 2004-2022 (r= 0.947, p= 0.0012). The daily animal fat intake did not show a significant correlation with the number of gout patients in adult women (aged ≥ 20 years) in 2004-2019 (r= -0.446, p= 0.375) and in 2004-2022 (r= -0.259, p= 0.575). This result suggests that the correlation of daily animal fat intake with the number of gout patients varies with gender and is stronger in adult men than in adult women.
Vegetable Fat
The vegetable fat is from grains, potatoes, legumes, seeds, nuts, fruit, vegetables, mushrooms, and seaweed.
The daily vegetable fat intake of Japanese people in 2022 was lower compared to that in 1989, 1992, and 1995 and was higher compared to that in 1986, 1998, 2007, 2010, 2013, 2016, and 2019 (1986: 28.7 g/day; 1989: 30.6 g/day; 1992: 29.9 g/day; 1995: 30.2 g/day; 1998: 28.7 g/day; 2007: 27.3 g/day; 2010: 26.7 g/day; 2013: 26.9 g/day; 2016: 28.1 g/day; 2019: 28.9 g/day; 2022: 29.4 g/day). The daily intake of vegetable fat was negatively correlated with the number of gout patients in 1986-2019 (r= -0.676, p= 0.0157). Whereas the daily intake of vegetable fat did not show a significant correlation with the number of gout patients in 1986-2022 (r= -0.502, p= 0.0807).
The daily vegetable fat intake of Japanese adult population (aged ≥ 20 years) in 2022 was higher compared to that in 2019 (2019: 29.3 g/day; 2022: 29.8 g/day). The daily intake of vegetable fat was positively correlated with the number of gout patients in the adult population (aged ≥ 20 years) in 2004-2019 (r= 0.835, p= 0.0388) and in 2004-2022 (r= 0.900, p= 0.00568).
The daily vegetable fat intake of Japanese adult men (aged ≥ 20 years) and adult women (aged ≥ 20 years) in 2022 were higher compared to those in 2019, respectively (men: 2019: 31.1 g/day; 2022: 31.9 g/day, women: 2019: 27.7 g/day; 2022: 28.0 g/day). The daily intake of vegetable fat was positively correlated with the number of gout patients in adult men (aged ≥ 20 years) in 2004-2019 (r= 0.872, p= 0.0235) and in 2004-2022 (r= 0.917, p= 0.00364). The daily intake of vegetable fat did not show a significant correlation with the number of gout patients in adult women (aged ≥ 20 years) in 2004-2019 (r= -0.371, p= 0.470), and in 2004-2022 (r= -0.199, p= 0.669). This result suggests that the correlation of daily vegetable fat intake with the number of gout patients varies with gender and is stronger in adult men than in adult women.
Saturated Fatty Acids
The daily intake of saturated fatty acids (SFAs) of Japanese in 2022 was lower compared to that in 1995 and was higher compared to that in 1998, 2002, 2005, 2007, 2010, 2013, and 2016 and was about the same as that in 2019 (1995: 18.4 g/day; 1998: 17.7 g/day; 2002: 14.3 g/day; 2005: 14.8 g/day; 2007: 15.0 g/day; 2010: 14.7 g/day; 2013: 15.1 g/day; 2016: 15.7 g/day; 2019: 18.3 g/day; 2022: 18.34 g/day). The daily intake of SFAs did not show a significant correlation with the number of gout patients in 2007–2019 (r= 0.855, p= 0.0650). Whereas the daily intake of SFAs was positively correlated with the number of gout patients in 2007-2022 (r= 0.911, p= 0.0116).
The daily intake of SFAs of Japanese adult population (aged ≥ 20 years) in 2022 was about the same as that in 2019 (2019: 17.9 g/day; 2022: 17.92 g/day). The daily intake of SFAs was positively correlated with the number of gout patients in the adult population (aged ≥ 20 years) in 2007–2019 (r= 0.890, p= 0.0431) and in 2007-2022 (r= 0.932, p= 0.00679).
The daily intake of SFAs of Japanese adult men (aged ≥ 20 years) in 2022 was about the same as that in 2019 (2019: 19.1 g/day; 2022: 19.12 g/day) The daily intake of SFAs of Japanese adult women (aged ≥ 20 years) in 2022 was higher compared to that in 2019 (2019: 16.7 g/day; 2022: 16.90 g/day). The daily intake of SFAs was positively correlated with the number of gout patients in adult men (aged ≥ 20 years) in 2007–2019 (r= 0.883, p= 0.0459) and in 2007-2022 (r= 0.927, p= 0.00789). The daily intake of SFAs did not show a significant correlation with the number of gout patients in adult women (aged ≥ 20 years) in 2007-2019 (r= -0.300, p= 0.624) and in 2007-2022 (r= 0.015, p= 0.977). This result suggests that the correlation of daily intake of SFAs with the number of gout patients is stronger in adult men than in adult women.
The Estimated Average Requirement (EAR), the Recommended Dietary Allowances (RDAs), the Adequate Intakes (AIs), and the Tolerable Upper Intake Levels (ULs) for SFAs in the U.S. population established by the Institutes of Medicine has not been set
[27] | Institute of Medicine of the National Academy of Sciences. Food and Nutrition Board. Dietary Reference Intakes: The essential guide to nutrient requirements. Washington, D.C. The National Academy Press. Available from: https://www.nap.edu/catalog/11537.html (accessed 14 October 2021). |
[68] | Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes: Recommended Dietary Allowances and Adequate Intakes, Total Water and Macronutrients. (2011) Washington, D.C. The National Academy Press. Available from: https://www.ncbi.nlm.nih.gov/books/NBK56068/table/summarytables.t4/?report=objectonly (accessed 18 October 2024). |
[27, 68]
. The Institute of Medicine of The National Academy in the U.S. has stated that recommendation for SFAs is as low possible while consuming a nutritionally adequate diet
[27] | Institute of Medicine of the National Academy of Sciences. Food and Nutrition Board. Dietary Reference Intakes: The essential guide to nutrient requirements. Washington, D.C. The National Academy Press. Available from: https://www.nap.edu/catalog/11537.html (accessed 14 October 2021). |
[27]
. The Institute of Medicine of The National Academy in the U.S. has not been set the EAR and the RDAs for SFAs
[27] | Institute of Medicine of the National Academy of Sciences. Food and Nutrition Board. Dietary Reference Intakes: The essential guide to nutrient requirements. Washington, D.C. The National Academy Press. Available from: https://www.nap.edu/catalog/11537.html (accessed 14 October 2021). |
[27]
.
Foods high in SFAs are as follows: oil (coconut oil, palm kernel oil, palm oil), coconut powder, butter (unfermented butter, fermented butter), shortening, beef tallow, lard, meat (beef: rib roast, rib loin, shoulder, thigh, pork: loin, shoulder, thigh), margarine, cream, natural cheese, white chocolate
[28] | The Council for Science and Technology, Ministry of Education, Culture, Sports, Science and Technology in Japan. Standard tables of food composition in Japan -2020- (Eighth Revised Edition), Report of the Subdivision Resources. Available from: https://www.mext.go.jp/content/20201225-mxt_kagsei-mext_01110_011.pdf (accessed 16 May 2020). |
[29] | The Council for Science and Technology, Ministry of Education, Culture, Sports, Science and Technology in Japan. Food Composition Database. Available from: https://fooddb.mext.go.jp/ (accessed 16 October 2024). |
[28, 29]
.
Japanese adult men (aged 20-49 years) and women (aged ≥ 20 years) should reduce the daily intake of SFAs for the prevention of gout.
Ratio of Energy Intake from Saturated Fatty Acids in Total Energy Intake
The mean ratio of energy intake from saturated fatty acids in total energy intake (SFAs/Energy) of Japanese people in 2022 was higher compared to that in 2016 and 2019 (2016: 7.54% of energy, 2019: 8.60% of energy; 2022: 8.74% of energy). The SFAs/Energy did not show a significant correlation with the number of gout patients in 2007-2016 (r=0.889, p= 0.111). Whereas the SFAs/Energy was positively correlated with the number of gout patients in 2007-2019 (r= 0.907, p= 0.0334) and in 2007-2022 (r= 0.943, p= 0.00474).
The SFAs/Energy of Japanese adult population (aged ≥ 20 years) in 2022 was higher compared to that in 2019 (2019: 8.39% of energy; 2022: 8.51% of energy). The SFAs/Energy was positively correlated with the number of gout patients in the adult population (aged ≥ 20 years) in 2007-2019 (r= 0.921, p= 0.0266) and in 2007-2022 (r= 0.943, p= 0.00474).
The SFAs/Energy of Japanese adult men (aged ≥ 20 years) and adult women (aged ≥ 20 years) in 2022 were higher compared to those in 2019, respectively (men: 2019: 8.05% of energy; 2022: 8.15% of energy, women: 2019: 8.77% of energy; 2022: 8.88% of energy). The SFAs/Energy was positively correlated with the number of gout patients in adult men (aged ≥ 20 years) in 2007-2019 (r= 0.906, p= 0.0340) and in 2007-2022 (r= 0.940, p= 0.00525). The SFAs/Energy did not show a significant correlation with the number of gout patients in adult women (aged ≥ 20 years) in 2007-2019 (r= -0.368, p= 0.642) and in 2007-2022 (r= -0.029, p= 0.956). This result suggests that the correlation of SFAs/Energy with the number of gout patients varies with gender and is stronger in adult men than in adult women.
The SFAs/Energy of Japanese men (aged ≥ 15 year) and women (aged ≥ 15 year) in 2022 were 8.08-9.27% of energy and 8.43-9.74% of energy, respectively, and exceeded the Tentative Dietary Goal for Preventing Lifestyle-related Diseases (DG) established by the Ministry of Health, Labour and Welfare in Japan (men and women: 15-17 years: ≤ 8% of energy; ≥ 18 years: ≤ 7% of energy)
. The Joint WHO/FAO Expert Consultation
[46] | Nishida, C., Uauy, R., Kumanyika, S., & Shetty, P. The joint WHO/FAO expert consultation on diet, nutrition and the prevention of chronic diseases: process, product and policy implications. Public Health Nutr. 2004, 7(1A), 245-250. https://doi.org/10.1079/phn2003592 |
[46]
has stated that the recommended SFAs/Energy is < 10% of total energy (calories).
This result suggests that decrease in intake of SFAs in Japanese people (aged ≥ 15 years) is important for prevention of gout.
Monounsaturated Fatty Acids
The daily intake of monounsaturated fatty acids (MUFAs) of Japanese people in 2022 was higher than that in 2007, 2010, 2013, 2016, and 2019 (2007: 18.70 g/day; 2010: 18.33 g/day; 2013: 18.82 g/day; 2016: 19.70 g/day; 2019: 22.50 g/day; 2022: 22.71 g/day). The daily intake of MUFAs did not show a significant correlation with the number of gout patients in 2007-2019 (r= 0.860, p= 0.0617). Whereas the daily intake of MUFAs was positively correlated with the number of gout patients in 2007-2022 (r= 0.915, p= 0.0106).
The daily intake of MUFAs of Japanese adult population (aged ≥ 20 years) in 2022 was higher compared to that in 2019 (2019: 22.53 g/day; 2022: 22.67 g/day). The daily intake of MUFAs was positively correlated with the number of gout patients in the adult population (aged ≥ 20 years) in 2007-2019 (r= 0.883, p= 0.0460) and in 2007-2022 (r= 0.929, p= 0.00733).
The daily intake of MUFAs of Japanese adult men (aged ≥ 20 years) and adult women (aged ≥ 20 years) in 2022 were higher compared to those in 2019 (men: 2019: 24.70 g/day; 2022: 24.83 g/day, women: 2019: 20.63 g/day; 2022: 20.81 g/day). The daily intake of MUFAs was positively correlated with the number of gout patients in adult men (aged ≥ 20 years) in 2007-2019 (r= 0.880, p= 0.0488) and in 2007-2022 (r= 0.924, p= 0.00843). The daily intake of MUFAs did not show a significant correlation with the number of gout patients in adult women (aged ≥ 20 years) in 2007-2019 (r= -0.314, p=0.0607) and in 2007-2022 (r= 0.00432, p= 0.994). This result suggests that the correlation of daily intake of MUFAs with the number of gout patients varies with gender and is stronger in adult men than in adult women.
Polyunsaturated Fatty Acids
The Joint WHO/FAO Expert Consultation
[46] | Nishida, C., Uauy, R., Kumanyika, S., & Shetty, P. The joint WHO/FAO expert consultation on diet, nutrition and the prevention of chronic diseases: process, product and policy implications. Public Health Nutr. 2004, 7(1A), 245-250. https://doi.org/10.1079/phn2003592 |
[46]
has stated that the recommended intake of polyunsaturated fatty acids (PUFAs) is 6-10% of total energy (calories). The Ministry of Health, Labour and Welfare of Japan
has not set the Tentative Dietary Goal for Preventing Lifestyle-related Diseases (DG) for the daily intake of n-3 polyunsaturated fatty acids (n-3 PUFAs) and n-6 polyunsaturated fatty acids (n-6 PUFAs) in Japanese men and women. The Estimated Average Requirement (EAR), the Recommended dietary allowances (RDAs), and the Tolerable Upper Intake Levels (ULs) for n-3 PUFAs and n-6 PUFAs in the U.S. population established by the Institutes of Medicine has not been set
[27] | Institute of Medicine of the National Academy of Sciences. Food and Nutrition Board. Dietary Reference Intakes: The essential guide to nutrient requirements. Washington, D.C. The National Academy Press. Available from: https://www.nap.edu/catalog/11537.html (accessed 14 October 2021). |
[68] | Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes: Recommended Dietary Allowances and Adequate Intakes, Total Water and Macronutrients. (2011) Washington, D.C. The National Academy Press. Available from: https://www.ncbi.nlm.nih.gov/books/NBK56068/table/summarytables.t4/?report=objectonly (accessed 18 October 2024). |
[27, 68]
.
The results of a recently published article are presented below. A cross-sectional study using US NHANES (2003-2015) data collected for 26323 subjects (13003 men and 13320 women) (aged ≥ 20 years) showed that higher intake of n-3 PUFAs, α-linolenic acid (ALA), n-6 PUFAs, linoleic acid, and non-marine PUFAs were associated with decreased hyperuricemia risk [hyperuricemia: SUA concentration > 420.0 µmol/L in men and > 360.0 µmol/L in women]
[82] | Chen, H., Yang, G., Chen, L., Zhao, Y., Yao, P., Li, Y., Tang, Y., Li, D. Dietary polyunsaturated fatty acids intake is negatively associated with hyperuricemia: the National Health and Nutrition Examination Survey 2003-2015. Nutr Metab Cardiovasc Dis. 2024, 34(9), 2203-2216. https://doi.org/10.1016/j.numecd.2024.05.026 |
[82]
. Detailed results are shown in the following sections. Replacing 5% of total energy intake from saturated fatty acids with isocaloric PUFAs was associated with decreased hyperuricemia risk
[82] | Chen, H., Yang, G., Chen, L., Zhao, Y., Yao, P., Li, Y., Tang, Y., Li, D. Dietary polyunsaturated fatty acids intake is negatively associated with hyperuricemia: the National Health and Nutrition Examination Survey 2003-2015. Nutr Metab Cardiovasc Dis. 2024, 34(9), 2203-2216. https://doi.org/10.1016/j.numecd.2024.05.026 |
[82]
. Aa a possible mechanism, Chen et al.
[82] | Chen, H., Yang, G., Chen, L., Zhao, Y., Yao, P., Li, Y., Tang, Y., Li, D. Dietary polyunsaturated fatty acids intake is negatively associated with hyperuricemia: the National Health and Nutrition Examination Survey 2003-2015. Nutr Metab Cardiovasc Dis. 2024, 34(9), 2203-2216. https://doi.org/10.1016/j.numecd.2024.05.026 |
[82]
have stated that insulin resistance, which leads to hyperuricemia by reducing UA excretion and activating xanthine oxidoreductase, is alleviated by replacing 5%-7.5% of total energy from SFAs with isocaloric PUFAs or n-6 PUFAs, or by administering a diet enriched in n-3 PUFAs.
Zhang et al.
[83] | Zhang, M., Zhang, Y., Terkeltaub, R., Chen, C., & Neogi, T. Effect of dietary and supplemental omega-3 polyunsaturated fatty acids on risk of recurrent gout flares. Arthritis Rheumatol. 2019, 71(9), 1580-1586. https://doi.org/10.1002/art.40896 |
[83]
found that higher n-3:n-6 ratio foods such as fatty fish was associated with lower risk of gout flares, more neutral n-3:n-6 ratio foods such as spinach had no effect on out flare risk, and lower n-3:n-6 ratio foods such as egg was associated with increased risk of gout flares.
Many epidemiological studies and clinical trials are needed to examine the effect of polyunsaturated fatty acids in the management of gout.
n-3 polyunsaturated fatty acids
The daily intake of n-3 polyunsaturated fatty acids (n-3 PUFAs) of Japanese people in 2022 was lower than that in 2007 and 2019 and was higher than that in 2013 and 2016 and was the same as that in 2010 (2007: 2.37 g/day; 2010: 2.24 g/day; 2013: 2.17 g/day; 2016: 2.16 g/day; 2019: 2.36 g/day; 2022: 2.24 g/day). The daily intake of n-3 PUFAs did not show a significant correlation with the number of gout patients in 2007-2019 (r= -0.0978, p= 0.876) and in 2007-2022 (r= -0.132, p= 0.803).
The daily intake of n-3 PUFAs of Japanese adult population (aged ≥ 20 years) in 2022 was lower than that in 2019 (2019: 2.46 g/day; 2022: 2.33 g/day). The daily intake of n-3 PUFAs did not show a significant correlation with the number of gout patients in the adult population (aged ≥ 20 years) in 2007-2019 (r= -0.0876, p= 0.889) and in 2007-2022 (r= -0.132, p= 0.803).
The daily intake of n-3 PUFAs of Japanese adult men (aged ≥ 20 years) in 2022 was lower compared to that in 2019 (2019: 2.68 g/day; 2022: 2.57 g/day). The daily intake of n-3 PUFAs of Japanese adult women (aged ≥ 20 years) in 2022 was lower compared to that in 2019 (2019: 2.27 g/day; 2022: 2.12 g/day). The daily intake of n-3 PUFAs did not show a significant correlation with the number of gout patients in adult men (aged ≥ 20 years) in 2007-2019 (r= -0.220, p= 0.723) and in 2007-2022 (r= -0.220, p= 0.675). The daily intake of n-3 PUFAs did not show a significant correlation with the number of gout patients in adult women (aged ≥ 20 years) in 2007-2019 (r= 0.130, p= 0.835) and in 2007-2022 (r= 0.065, p= 0.902).
The daily intake of n-3 PUFAs for men (aged ≥ 15 year) and women (aged ≥ 15 years) in 2022 were 2.29-2.91 g/day and 1.74-2.43 g/day, respectively, and exceeded the Adequate Intakes (AIs) established by the Ministry of Health, Labour and Welfare in Japan [men (aged ≥ 15 years): 2.0-2.2 g/day; women (aged ≥ 7 years): 1.6-2.0 g/day]
. This result suggests that the daily intake of n-3 PUFAs in Japanese men (aged ≥ 15 years) and women (aged ≥ 15 years) appears to be very unlikely to cause a deficiency. The Estimated Average Requirement (EAR) and the Recommended Dietary Allowances (RDAs) for n-3 PUFAs in the U.S. population established by the Institutes of Medicine has not been established
[27] | Institute of Medicine of the National Academy of Sciences. Food and Nutrition Board. Dietary Reference Intakes: The essential guide to nutrient requirements. Washington, D.C. The National Academy Press. Available from: https://www.nap.edu/catalog/11537.html (accessed 14 October 2021). |
[68] | Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes: Recommended Dietary Allowances and Adequate Intakes, Total Water and Macronutrients. (2011) Washington, D.C. The National Academy Press. Available from: https://www.ncbi.nlm.nih.gov/books/NBK56068/table/summarytables.t4/?report=objectonly (accessed 18 October 2024). |
[27, 68]
. The Joint WHO/FAO Expert Consultation
[46] | Nishida, C., Uauy, R., Kumanyika, S., & Shetty, P. The joint WHO/FAO expert consultation on diet, nutrition and the prevention of chronic diseases: process, product and policy implications. Public Health Nutr. 2004, 7(1A), 245-250. https://doi.org/10.1079/phn2003592 |
[46]
has stated that the recommended intake of n-3 PUFAs is 1-2% of total energy (calories). The Institute of Medicine of the National Academy of Sciences in the U.S. has determined that the Acceptable Macronutrient Distribution Ranges (AMDRs) for n-3 polyunsaturated fatty acids (α-linolenic acid) both adults (aged ≥ 19 years) and children (aged 4-18 years) is 0.6-1.2 percent of total calories
[27] | Institute of Medicine of the National Academy of Sciences. Food and Nutrition Board. Dietary Reference Intakes: The essential guide to nutrient requirements. Washington, D.C. The National Academy Press. Available from: https://www.nap.edu/catalog/11537.html (accessed 14 October 2021). |
[27]
. The Institute of Medicine of the National Academy of Sciences in the U.S. has established that the AIs for α-linolenic acid is 1.2-1.6 g/day for males (aged ≥ 9 years) and 1.0-1.1 g/day for females (aged ≥ 9 years), respectively [males (aged 9-13 years): 1.2 g/day; males (aged ≥ 14 years): 1.6 g/day; females (aged 9-13 years): 1.0 g/day; females (aged ≥ 14 years): 1.1 g/day]
[27] | Institute of Medicine of the National Academy of Sciences. Food and Nutrition Board. Dietary Reference Intakes: The essential guide to nutrient requirements. Washington, D.C. The National Academy Press. Available from: https://www.nap.edu/catalog/11537.html (accessed 14 October 2021). |
[27]
.
The n-3 PUFAs are known for their powerful anti-inflammatory effects
[84] | Abhishek, A., Valdes, A. M., Doherty, M. Low omega-3 fatty acid levels associate with frequent gout attacks: a case control study. Annals of the Rheumatic Diseases. 2016, 75(4), 784-785. https://doi.org/10.1136/annrheumdis-2015-208767 |
[84]
. Anti-inflammatory effects of n-3 PUFAs in experimental gout in mice or rats are presented below. Omega-3-carboxylic acids [purified eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), palmitic acid, and oleic acid] reduced interleukin-1β (IL-1β) and prostaglandin E2 production, exudate volume, and white blood cell (WBC) infiltration in rat monosodium urate (MSU) crystal air pouch model and inhibited pain and swelling in rat knee intra-articular MSU injection model, suggesting omega-3-carboxylic acids has anti-inflammatory effects
[85] | Iverson, C., Bacong, A., Liu, S., Baumgartner, S., Lundström, T., Oscarsson, J., Miner, J. N. Omega-3-carboxylic acids provide efficacious anti-inflammatory activity in models of crystal-mediated inflammation. Scientific Reports. 2018, 8(1), 1217. https://doi.org/10.1038/s41598-018-19252-x |
[85]
. Yan et al.
[86] | Yan, Y., Jiang, W., Spinetti, T., Tardivel, A., Castillo, R., Bourquin, C., Guarda, G., Tian, Z., Tschopp, J., Zhou, R. Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Immunity. 2013, 38(6), 1154-1163. https://doi.org/10.1016/j.immuni.2013.05.015 |
[86]
found that DHA prevents inflammation and metabolic disorder through inhibition of nucleotide-binding and oligomerization domain-like receptor, leucine-rich repeat and pyrin domain-containing 3 (NLRP3) inflammasome activation in mice. Diets enriched in both linolenic acid and EPA significantly suppressed urate crystal-induced inflammation in a rat model
[87] | Tate, G. A., Mandell, B. F., Karmali, R. A., Laposata, M., Baker, D. G., Schumacher, H. R. Jr., Zurier, R. B. Suppression of monosodium urate crystal-induced acute inflammation by diets enriched with gamma-linolenic acid and eicosapentaenoic acid. Arthritis Rheum. 1988, 31(12), 1543-1551. https://doi.org/10.1002/art.1780311211 |
[87]
. EPA and DHA inhibit pathways like toll-like receptor activation, NALP-3 inflammasome assembly, neutrophil chemotaxis, prostaglandin synthesis and nucleating factor-kB activity through which MSU crystals induce inflammation
[84] | Abhishek, A., Valdes, A. M., Doherty, M. Low omega-3 fatty acid levels associate with frequent gout attacks: a case control study. Annals of the Rheumatic Diseases. 2016, 75(4), 784-785. https://doi.org/10.1136/annrheumdis-2015-208767 |
[84]
. These n-3 PUFAs show a potential protective role against gout flares.
A cross-sectional study using US NHANES (2003-2015) showed that US adults in the highest quartile of intake of n-3 PUFAs and α-linolenic acid (ALA) were 23.0% and 31.0% less likely to be hyperuricemia [hyperuricemia: SUA concentration ≥ 420 µmol/L in men and ≥ 360 µmol/L) in women] compared to those subjects in the lowest quartile of intake of each PUFAs, respectively
[82] | Chen, H., Yang, G., Chen, L., Zhao, Y., Yao, P., Li, Y., Tang, Y., Li, D. Dietary polyunsaturated fatty acids intake is negatively associated with hyperuricemia: the National Health and Nutrition Examination Survey 2003-2015. Nutr Metab Cardiovasc Dis. 2024, 34(9), 2203-2216. https://doi.org/10.1016/j.numecd.2024.05.026 |
[82]
. As one of possible mechanisms of the association between n-3 PUFAs intake and hyperuricemia, The
in vitro study showed that EPA, ALA, and DHA strongly inhibited urate transporter 1 (URAT1), which are UA reabsorption proteins, activities and n-3 PUFAs inhibited the function of URAT 1 more effectively than saturated fatty acids (SFAs)
[88] | Saito, H., Toyoda, Y., Takada, T., Hirata, H., Ota-kontani, A., Miyata, H., Kobayashi, N., Tsuchiya, Y., Suzuki, H. n-3 polyunsaturated fatty acids inhibit the function of human URAT 1, a renal urate re-absorber. Nutrients. 2020, 12(6), 1601. https://doi.org/10.3390/nu12061601 |
[88]
. Saito et al.
[88] | Saito, H., Toyoda, Y., Takada, T., Hirata, H., Ota-kontani, A., Miyata, H., Kobayashi, N., Tsuchiya, Y., Suzuki, H. n-3 polyunsaturated fatty acids inhibit the function of human URAT 1, a renal urate re-absorber. Nutrients. 2020, 12(6), 1601. https://doi.org/10.3390/nu12061601 |
[88]
have stated that n-3 PUFAs can be employed as uricosuric agents. The n-3 PUFAs will be preferable nutrients for the prevention of hyperuricemia/gout.
The results of a recently clinical trial are presented below. A randomized controlled trial in 74 healthy men and women for 6 weeks showed that intervention with ALA, EPA, or DHA diets did not significantly decrease plasma UA concentrations
[89] | Egert, S., Lindenmeier, M., Harnack, K., Krome, K., Erbersdobler, H. F., Wahrburg, U., Somoza, V. Margarines fortified with α-linolenic acid, eicosapentaenoic acid, or docosahexaenoic acid alter the fatty acid composition of erythrocytes but do not affect the antioxidant status of healthy adults. The Journal of Nutrition. 2012, 142(9), 1638-1644. https://doi.org/10.3945/jn.112.161802 |
[89]
. Whereas mean plasma UA concentrations of ALA, EPA, or DHA group at baseline (ALA: 239 μmol/L; EPA: 264 μmol/L; EPA: 240 μmol/L) and 6- week intervention (ALA: 231 μmol/L; EPA: 247 μmol/L; EPA: 232 μmol/L) were within the normal physiological range [2.0-7.0 mg/dL (119.0-416.4 μmol/L) for men and 2.0-6.5 mg/dL (119.0-386.7 μmol/L) for women
[90] | Ekpenyong, C. E., Daniel, N. Roles of diets and dietary factors in the pathogenesis, management and prevention of abnormal serum uric acid levels. Pharma Nutrition. 2015, 3(2), 29-45. https://doi.org/10.1016/j.phanu.2014.12.001 |
[90]
], respectively. A randomized controlled trial involving 30 Chinese participants for 8 weeks showed that intake of fish oil increased plasma saturated fatty acids and n-3 PUFAs concentrations and decreased plasma n-6 PUFAs, UA, triacylglycerol, C-reactive protein, and ferritin concentrations compared with baseline
[91] | Huang, T., Li, K., Asimi, S., Chen, Q., Li, D. Effect of vitamin B-12 and n-3 polyunsaturated fatty acids on plasma homocysteine, ferritin, C-reactive protein, and other cardiovascular risk factors: a randomized controlled trial. Asia Pac J Clin Nutr. 2015, 24(3), 403-411. https://doi.org/10.6133/apjcn.2015.24.3.19 |
[91]
. In a case-control study, Li et al.
[92] | Li, K., Wu, K., Zhao, Y., Huang, T., Lou, D., Yu, X., Li, D. Interaction between marine-derived n-3 long chain polyunsaturated fatty acids and uric acid on glucose metabolism and risk of type 2 diabetes mellitus: a case-control study. Mar Drugs. 2015, 13(9), 5564-5578. https://doi.org/10.3390/md13095564 |
[92]
observed a negative association between plasma DHA and plasma UA concentrations. On the contrary, A randomized controlled trial involving 34 male overweight subjects showed that a ketogenic Mediterranean diet with n-3 PUFAs for 4 weeks had no effect on UA concentration
[93] | Paoli, A., Moro, T., Bosco, G., Bianco, A., Grimaldi, K. A., Camporesi, E., Mangar, D. Effects of n-3 polyunsaturated fatty acids (ω-3) supplementation on some cardiovascular risk factors with a ketogenic Mediterranean diet. Mar Drugs. 2015, 13(2), 996-1009. https://doi.org/10.3390/md13020996 |
[93]
. From results of these reports, Chen et al.
[82] | Chen, H., Yang, G., Chen, L., Zhao, Y., Yao, P., Li, Y., Tang, Y., Li, D. Dietary polyunsaturated fatty acids intake is negatively associated with hyperuricemia: the National Health and Nutrition Examination Survey 2003-2015. Nutr Metab Cardiovasc Dis. 2024, 34(9), 2203-2216. https://doi.org/10.1016/j.numecd.2024.05.026 |
[82]
have stated that the inconsistency on the effect of n-3 PUFAs on serum or plasma UA concentrations may stem from variations in the composition or dosage of n-3 PUFAs.
In a pilot randomized open-label clinical trial in patients with gout (aged ≥ 18 years) for 6 months, no significant differences were detected in the SUA concentrations and the percentage of participants experiencing at least one flare each month between omega-three fish oil (6.2 g of omega-3 fatty acids per day) supplementation and controls for intervention periods, respectively
[94] | Stamp, L. K., Grainger, R., Frampton, C., Drake, J., Hill, C. L. Effect of omega-three supplementation on serum urate and gout flares in people with gout: a pilot randomized trial. BMC Rheumatol. 2022, 6(1), 31. https://doi.org/10.1186/s41927-022-00263-1 |
[94]
. However, red cell omega-3 concentrations significantly correlated with the number of gout flare-ups
[94] | Stamp, L. K., Grainger, R., Frampton, C., Drake, J., Hill, C. L. Effect of omega-three supplementation on serum urate and gout flares in people with gout: a pilot randomized trial. BMC Rheumatol. 2022, 6(1), 31. https://doi.org/10.1186/s41927-022-00263-1 |
[94]
. Abhishek et al.
[84] | Abhishek, A., Valdes, A. M., Doherty, M. Low omega-3 fatty acid levels associate with frequent gout attacks: a case control study. Annals of the Rheumatic Diseases. 2016, 75(4), 784-785. https://doi.org/10.1136/annrheumdis-2015-208767 |
[84]
found that low serum levels of n-3 PUFAs were associated with frequent gout attacks. In a cohort study on 724 gout patients, intake of n-3 PUFA rich fatty fish was associated with a lower risk of gout flare-up, while intake of n-3 PUFA rich supplements did not reduce the risk of gout flares recurrence
[83] | Zhang, M., Zhang, Y., Terkeltaub, R., Chen, C., & Neogi, T. Effect of dietary and supplemental omega-3 polyunsaturated fatty acids on risk of recurrent gout flares. Arthritis Rheumatol. 2019, 71(9), 1580-1586. https://doi.org/10.1002/art.40896 |
[83]
.
Nuts and seeds contain rich in n-3 polyunsaturated fatty acids (ALA)
[28] | The Council for Science and Technology, Ministry of Education, Culture, Sports, Science and Technology in Japan. Standard tables of food composition in Japan -2020- (Eighth Revised Edition), Report of the Subdivision Resources. Available from: https://www.mext.go.jp/content/20201225-mxt_kagsei-mext_01110_011.pdf (accessed 16 May 2020). |
[30] | U.S. Department of Health & Human Services. National Institutes of Health. Office of Dietary Supplements. Dietary Supplement Fact Sheets. Available from: https://ods.od.nih.gov/factsheets/list-all/ (accessed 17 May 2020). |
[28, 30]
. Fatty fish, such as tuna, mackerel, and salmon, contains rich in n-3 polyunsaturated fatty acids [EPA and DHA]
[28] | The Council for Science and Technology, Ministry of Education, Culture, Sports, Science and Technology in Japan. Standard tables of food composition in Japan -2020- (Eighth Revised Edition), Report of the Subdivision Resources. Available from: https://www.mext.go.jp/content/20201225-mxt_kagsei-mext_01110_011.pdf (accessed 16 May 2020). |
[30] | U.S. Department of Health & Human Services. National Institutes of Health. Office of Dietary Supplements. Dietary Supplement Fact Sheets. Available from: https://ods.od.nih.gov/factsheets/list-all/ (accessed 17 May 2020). |
[28, 30]
. Foods high in ALA, EPA and DHA are as follows: oil (flaxseed oil, canola oil, soybean oil), seeds and nuts (chia seeds, English walnuts, flaxseed, black walnuts), seafood (salmon, herring, sardines, mackerel, trout, oysters, sea bass, shrimp, lobster, tuna, tilapia, scallops, cod), legumes (edamame, refried beans, kidney beans, baked beans), meat (ground beef, chicken breast), bread, egg, low-fat milk, mayonnaise
. One should consume at least 250 mg/day of long-chain n-3 PUFAs or at least 2 servings/week of oily fish
[96] | Mozaffarian, D., Wu, J. H. Y. Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events. J Am Coll Cardiol. 2011, 58(20), 2047-2067. https://doi.org/10.1016/j.jacc.2011.06.063 |
[96]
.
It seems important for Japanese people to eat fatty fish, nuts, and seeds to take in more n-3 PUFAs for the prevention and management of gout.
n-6 polyunsaturated fatty acids
The daily intake of n-6 polyunsaturated fatty acids (n-6 PUFAs) of Japanese people in 2022 was higher compared to that in 2007, 2010, 2013, 2016, and 2019 (2007: 9.45 g/day; 2010: 9.27 g/day; 2013: 9.28 g/day; 2016: 9.61 g/day; 2019: 10.50 g/day; 2022: 10.78 g/day). The daily intake of n-6 PUFAs did not show a significant correlation with the number of gout patients in 2007–2019 (r= 0.776, p= 0.123). Whereas the daily intake of n-6 PUFAs was positively correlated with the number of gout patients in 2007-2022 (r= 0.867, p= 0.0252).
The daily intake of n-6 PUFAs of Japanese adult population (aged ≥ 20 years) in 2022 was higher compared to that in 2016 and 2019 (2016: 9.73 g/day; 2019: 10.66 g/day; 2022: 10.88 g/day). The daily intake of n-6 PUFAs did not show a significant correlation with the number of gout patients in the adult population (aged ≥ 20 years) in 2007–2019 (r= 0.820, p= 0.0890). Whereas the daily intake of n-6 PUFAs was positively correlated with the number of gout patients in the adult population (aged ≥ 20 years) in 2007-2022 (r= 0.893, p= 0.0166).
The daily intake of n-6 PUFAs of Japanese adult men (aged ≥ 20 years) and adult women (aged ≥ 20 years) in 2022 were higher compared to those in 2019, respectively (men: 2019: 11.61 g/day; 2022: 11.90 g/day, women: 2019: 9.84 g/day; 2022: 10.00 g/day). The daily intake of n-6 PUFAs did not show a significant correlation with the number of gout patients in adult men (aged ≥ 20 years) in 2007–2019 (r= 0.837, p= 0.0769). Whereas the daily intake of n-6 PUFAs was positively correlated with the number of gout patients in adult men (aged ≥ 20 years) in 2007-2022 (r= 0.896, p= 0.0156). The daily intake of n-6 PUFAs did not show a significant correlation with the number of gout patients in adult women (aged ≥ 20 years) in 2007-2019 (r= -0.323, p= 0.596) and in 2007-2022 (r= 0.022, p= 0.968). This result suggests that the correlation of daily intake of n-6 PUFAs with the number of gout patients varies with gender and is stronger in adult men than in adult women.
The daily intake of n-6 PUFAs of Japanese men (aged 15-19 years), men (aged ≥ 20 years), women (aged 15-19 years), and women (aged ≥ 20 years) in 2022 were 14.59 g/day, 10.41-12.76 g/day, 10.85 g/day, and 9.03-10.63 g/day, respectively, and exceeded the Adequate Intakes (AIs) established by the Ministry of Health, Labour and Welfare in Japan [men (aged 15-17 years): 13.0 g/day; men (aged 18-29 years): 11.0 g/day; men (aged ≥ 30 years): 8.0-10.0 g/day; women (aged 15-17 years): 9.0 g/day; women (aged 18-74 years): 8.0 g/day; women (aged ≥ 75 years): 7.0 g/day]
. The Institute of Medicine of the National Academy of Sciences in the U.S. has established that the AIs for linoleic acid is 14.0-17.0 g/day for males (aged ≥ 14 years) and 11.0-12.0 g/day for females (aged ≥ 14 years), respectively [males (aged 14-18 years): 16.0 g/day; males (aged 19-50 years): 17.0 g/day; males (aged ≥ 51 years): 14.0 g/day; females (aged 14-18 years): 11.0 g/day; females (aged 19-50 years): 12.0 g/day; females (aged ≥ 51 years): 11.0 g/day]
[27] | Institute of Medicine of the National Academy of Sciences. Food and Nutrition Board. Dietary Reference Intakes: The essential guide to nutrient requirements. Washington, D.C. The National Academy Press. Available from: https://www.nap.edu/catalog/11537.html (accessed 14 October 2021). |
[27]
. Though n-6 PUFAs researched by the Ministry of Health, Labour and Welfare in Japan were not only linoleic acid (98%), the daily intake of n-6 PUFAs of Japanese men (aged ≥ 15 years) and Japanese women (aged ≥ 15 years) in 2022 were below the AIs established by The Institute of Medicine of the National Academy of Sciences in the U.S. Considering the AIs established by the Ministry of Health, Labour and Welfare in Japan, the daily intake of n-6 PUFAs in Japanese men and women (aged ≥ 15 years) appears to be very unlikely to cause a deficiency. However, it seems better to increase the daily intake of n-6 PUFAs slightly.
The Joint WHO/FAO Expert Consultation
[46] | Nishida, C., Uauy, R., Kumanyika, S., & Shetty, P. The joint WHO/FAO expert consultation on diet, nutrition and the prevention of chronic diseases: process, product and policy implications. Public Health Nutr. 2004, 7(1A), 245-250. https://doi.org/10.1079/phn2003592 |
[46]
has stated that the recommended intake of n-6 PUFAs is 5-8% of total energy (calories). The Institute of Medicine of the National Academy of Sciences in the U.S. has determined that the Acceptable Macronutrient Distribution Ranges (AMDRs) for n-6 PUFAs (linoleic acid) both adults (aged ≥ 19 years) and children (aged 4-18 years) is 5-10 percent of total calories
[27] | Institute of Medicine of the National Academy of Sciences. Food and Nutrition Board. Dietary Reference Intakes: The essential guide to nutrient requirements. Washington, D.C. The National Academy Press. Available from: https://www.nap.edu/catalog/11537.html (accessed 14 October 2021). |
[27]
.
A cross-sectional study using US NHANES (2003-2015) showed that US adults in the highest quartile of intake of n-6 PUFAs and linoleic acid were 25.0% and 25.0% less likely to be hyperuricemia [hyperuricemia: SUA concentration ≥ 420 µmol/L in men and ≥ 360 µmol/L) in women] compared to those subjects in the lowest quartile of intake of each PUFAs, respectively
[82] | Chen, H., Yang, G., Chen, L., Zhao, Y., Yao, P., Li, Y., Tang, Y., Li, D. Dietary polyunsaturated fatty acids intake is negatively associated with hyperuricemia: the National Health and Nutrition Examination Survey 2003-2015. Nutr Metab Cardiovasc Dis. 2024, 34(9), 2203-2216. https://doi.org/10.1016/j.numecd.2024.05.026 |
[82]
. As one of possible mechanisms of the association between PUFAs intake and hyperuricemia, Chen et al.
[82] | Chen, H., Yang, G., Chen, L., Zhao, Y., Yao, P., Li, Y., Tang, Y., Li, D. Dietary polyunsaturated fatty acids intake is negatively associated with hyperuricemia: the National Health and Nutrition Examination Survey 2003-2015. Nutr Metab Cardiovasc Dis. 2024, 34(9), 2203-2216. https://doi.org/10.1016/j.numecd.2024.05.026 |
[82]
have stated that lower γ-linoleic acid (biomarker reflecting habitual consumption of n-6 PUFAs) was associated with increased abundance of gut microbiota.
Foods high in n-6 PUFAs are as follows: oil (safflower oil, grape oil, sunflower oil, cottonseed oil, corn oil, soybean oil, chili oil, sesame oil, rice bran oil, rapeseed oil), seeds and nuts (walnuts, poppy seeds, pine nuts, Brazil nuts, sunflower seeds, sesame seeds, pecans, peanuts, pistachio nuts, almonds), seafood (sardines canned, bonito canned, tuna canned), soybeans, yuba, mayonnaise
. It seems important for Japanese people to eat above-mentioned foods to take in more n-6 PUFAs to reach the AIs established by The Institute of Medicine of the National Academy of Sciences in the U.S.
Cholesterol
The daily intake of cholesterol of Japanese people in 2022 was lower compared to that in 1995 and 1998, and was higher compared to that in 2001, 2004, 2007, 2010, 2013, and 2016, and 2019 (1995: 383 mg/day; 1998: 370 mg/day; 2001: 346 mg/day; 2004: 320 mg/day; 2007: 323 mg/day; 2010: 307 mg/day; 2013: 307 mg/day; 2016: 311 mg/day; 2019 335 mg/day; 2022 347 mg/day). The daily cholesterol intake did not show a significant correlation with the number of gout patients in 2004-2019 (r= 0.294, p= 0.572) and in 2004-2022 (r= 0.614, p= 0.143).
The daily intake of cholesterol of Japanese adult population (aged ≥ 20 years) in 2022 was higher compared to that in 2019 (2019: 340 mg/day; 2022 352 mg/day). The daily cholesterol intake did not show a significant correlation with the number of gout patients in the adult population (aged ≥ 20 years) in 2004-2019 (r= 0.461, p= 0.357) and in 2004-2022 (r= 0.703, p= 0.078).
The daily cholesterol intake of Japanese adult men (aged ≥ 20 years) and adult women (aged ≥ 20 years) in 2022 were higher compared to those in 2019, respectively (men: 2019: 366 mg/day; 2022 379 mg/day, women: 2019: 317 mg/day; 2022 328 mg/day). The daily cholesterol intake did not show a significant correlation with the number of gout patients in adult men (aged ≥ 20 years) in 2004-2019 (r= 0.398, p= 0.447) and in 2004-2022 (r= 0.651, p= 0.113). The daily cholesterol intake did not show a significant correlation with the number of gout patients in adult women (aged ≥ 20 years) in 2004-2019 (r= -0.0160, p= 0.976) and in 2004-2022 (r= 0.100, p= 0.831).
The Ministry of Health, Labour and Welfare of Japan
has not set an index for the daily intake of cholesterol in Japanese adults. The Estimated Average Requirement (EAR), the Recommended Dietary Allowances (RDAs), the Adequate Intakes (AIs), and the Tolerable Upper Intake Levels (ULs) for cholesterol in the U.S. population established by the Institutes of Medicine has not been set
[27] | Institute of Medicine of the National Academy of Sciences. Food and Nutrition Board. Dietary Reference Intakes: The essential guide to nutrient requirements. Washington, D.C. The National Academy Press. Available from: https://www.nap.edu/catalog/11537.html (accessed 14 October 2021). |
[68] | Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes: Recommended Dietary Allowances and Adequate Intakes, Total Water and Macronutrients. (2011) Washington, D.C. The National Academy Press. Available from: https://www.ncbi.nlm.nih.gov/books/NBK56068/table/summarytables.t4/?report=objectonly (accessed 18 October 2024). |
[27, 68].
The Institute of Medicine of the National Academy of Sciences in the U.S. has stated that recommendation for dietary cholesterol is as low possible while consuming a nutritionally adequate diet
[27] | Institute of Medicine of the National Academy of Sciences. Food and Nutrition Board. Dietary Reference Intakes: The essential guide to nutrient requirements. Washington, D.C. The National Academy Press. Available from: https://www.nap.edu/catalog/11537.html (accessed 14 October 2021). |
[27]
. The Joint WHO/FAO Expert Consultation
[46] | Nishida, C., Uauy, R., Kumanyika, S., & Shetty, P. The joint WHO/FAO expert consultation on diet, nutrition and the prevention of chronic diseases: process, product and policy implications. Public Health Nutr. 2004, 7(1A), 245-250. https://doi.org/10.1079/phn2003592 |
[46]
has stated that the recommended intake of cholesterol is < 300 mg/day. The mean daily intake of cholesterol of Japanese people, Japanese men (aged ≥ 20 years), and Japanese women (aged ≥ 20 years) in 2022 were 347 mg/day, 379 mg/day, and 328 mg/day, respectively, and exceeded the recommended intake of cholesterol established by The Joint WHO/FAO Expert Consultation. The Ministry of Health, Labour and Welfare in Japan
has stated that, for the daily cholesterol intake, it is desirable to take less than 200 mg from the viewpoint of preventing aggravation of dyslipidemia. Thus, it is important for Japanese people to reduce daily cholesterol intake to prevent the aggravation of dyslipidemia. It seems that decreasing intake of cholesterol and/or avoidance of excessive intake of cholesterol in Japanese adults is important for the prevention of lifestyle-related diseases including gout.
The results of a recently published article are presented below. A cross-sectional study using US NHANES (2017-2018) data showed that no statistical difference was found about the associations of dietary cholesterol intake with SUA concentrations
[31] | Yao, J., Zhang, Y., Zhao, J., Lin, Y-P., Lu, Q-Y., Fan, G-J. Cor relation of obesity, dietary patterns, and blood pressure with uric acid: data from the NHANES 2017-2018. BMC Endocr Disord. 2022, 22(1), 196. https://doi.org/10.1186/s12902-022-01112-5 |
[31]
.
Foods high in cholesterol are as follows: liver, egg yolk, dried herring roe, dried squid, anchovy, sardines, shrimp, abalone, salmon, mackerel, sea urchin, carp, sweet fish, lobster, full-fat dairy products
[27] | Institute of Medicine of the National Academy of Sciences. Food and Nutrition Board. Dietary Reference Intakes: The essential guide to nutrient requirements. Washington, D.C. The National Academy Press. Available from: https://www.nap.edu/catalog/11537.html (accessed 14 October 2021). |
[28] | The Council for Science and Technology, Ministry of Education, Culture, Sports, Science and Technology in Japan. Standard tables of food composition in Japan -2020- (Eighth Revised Edition), Report of the Subdivision Resources. Available from: https://www.mext.go.jp/content/20201225-mxt_kagsei-mext_01110_011.pdf (accessed 16 May 2020). |
[27, 28]
.
Ratio of Energy Intake from Fat in Total Energy Intake
The mean ratio of energy intake from fat in total energy intake (Fat/Energy) of Japanese people in 2022 was higher compared to that in 1975, 1980, 1986, 1989, 1992, 1995, 1998, 2001, 2004, 2007, 2010, 2013, 2016, and 2019 (1975: 22.3%; 1980: 23.6%; 1986: 24.5%; 1989: 25.7%; 1992: 25.5%; 1995: 26.2%; 1998: 26.1%; 2001: 25.2%; 2004: 25.3%; 2007: 25.8%; 2010: 25.9%; 2013: 26.2%; 2016: 27.4%; 2019: 28.6%; 2022: 29.1%). The Fat/Energy was positively correlated with the number of gout patients in 1986-2019 (r= 0.660, p= 0.0195) and in 1986-2022 (r= 0.737, p= 0.00409).
The Fat/Energy of Japanese adult population (aged ≥ 20 years) in 2022 was higher compared to that in 2019 (2019: 28.4% of energy; 2022: 28.9% of energy). The Fat/Energy was positively correlated with the number of gout patients in the adult population (aged ≥ 20 years) in 2004-2019 (r= 0.953, p= 0.00328) and in 2004-2022 (r= 0.971, p= 0.00027).
The Fat/Energy of Japanese adult men (aged ≥ 20 years) and adult women (aged ≥ 20 years) in 2022 were higher compared to those in 2019, respectively (men: 2019: 27.4% of energy; 2022: 28.1% of energy, women: 2019: 29.2% of energy; 2022: 29.5% of energy). The Fat/Energy was positively correlated with the number of gout patients in adult men (aged ≥ 20 years) in 2004-2019 (r= 0.966, p= 0.00170) and in 2004-2022 (r= 0.975, p= 0.00019). The Fat/Energy did not show a significant correlation with the number of gout patients in adult women (aged ≥ 20 years) in 2004-2019 (r= -0.619, p= 0.190) and in 2004-2022 (r= -0.396, p= 0.379). This result suggests that the correlation of the Fat/Energy with the number of gout patients varies with gender and is stronger in adult men than in adult women.
The Fat/Energy of Japanese men (aged ≥ 20 years) and women (aged ≥ 60 years) in 2022 were 25.5-29.8% of energy, and 26.4-29.6% of energy, respectively, and were within the Tentative Dietary Goal for Preventing Lifestyle-related Diseases (DG) established by the Ministry of Health, Labour and Welfare in Japan [men (aged ≥ 15 year): 20-30% of energy; women (aged ≥ 15 year): 20-30% of energy]
. The Fat/Energy for Japanese men (15-19 years) and women (15-59 years) were 30.2% of energy and 30.3-32.4% of energy, respectively, and exceeded the DG established by the Ministry of Health, Labour and Welfare in Japan [men (aged ≥ 15 year): 20-30% of energy; women (aged ≥ 15 year): 20-30% of energy]
. The Institute of Medicine of the National Academy of Sciences in the U.S. has determined that the Acceptable Macronutrient Distribution Ranges (AMDRs) for total fat at 20-35 percent of total calories for adults (aged ≥ 19 years) and at 25-35 percent of total calories for children (aged 4-18 years) and 30-40 percent of total calories for children (aged 1-3 years)
[27] | Institute of Medicine of the National Academy of Sciences. Food and Nutrition Board. Dietary Reference Intakes: The essential guide to nutrient requirements. Washington, D.C. The National Academy Press. Available from: https://www.nap.edu/catalog/11537.html (accessed 14 October 2021). |
[27]
. The mean ratio of energy intake from fat in total energy intake (Fat/Energy) of Japanese adult men (aged ≥ 20 years) and Japanese adult women (aged ≥ 20 years) in 2022 were 28.1% of energy and 29.5% of energy, respectively, and were within the AMDRs. The Joint WHO/FAO Expert Consultation
[46] | Nishida, C., Uauy, R., Kumanyika, S., & Shetty, P. The joint WHO/FAO expert consultation on diet, nutrition and the prevention of chronic diseases: process, product and policy implications. Public Health Nutr. 2004, 7(1A), 245-250. https://doi.org/10.1079/phn2003592 |
[46]
has stated that the recommended the Fat/Energy is 15-30% of total energy (calories). The Fat/Energy for Japanese women (15-59 years) exceeded the recommended the Fat/Energy established by the Joint WHO/FAO Expert Consultation
[46] | Nishida, C., Uauy, R., Kumanyika, S., & Shetty, P. The joint WHO/FAO expert consultation on diet, nutrition and the prevention of chronic diseases: process, product and policy implications. Public Health Nutr. 2004, 7(1A), 245-250. https://doi.org/10.1079/phn2003592 |
[46]
. The Fat/Energy was positively correlated with the number of gout patients in 1986-2022 (r= 0.737, p= 0.00409). It seems better to decrease the Fat/Energy.
3.3.5. Caloric Ratio of Protein, Fat, and Carbohydrate
The number of gout patients of Japanese people increased 0.052 million people from 2019 to 2022 (2019: 1.254 million; 2022: 1.306 million). Compared to the Japanese diet in 2019, in the Japanese diet in 2022, the Protein/Energy was the same and the Fat/Energy increased by 0.5% and the Carbohydrate /Energy decreased by 0.5%. The Fat/Energy in 1986-2022 and Saturated fatty acids/Energy in 2007-2022 were positively correlated with the number of gout patients, respectively. It is speculated that one of the factors contributing to the increase in the number of gout patients is the increased intake of fat, particularly saturated fatty acids.
The balance of the caloric ratio of protein, fat, and carbohydrate of Japanese people in 2022 was protein: 15.1%, fat: 29.1%, and carbohydrates: 55.8%. As described above-mentioned sections, The balance of the caloric ratio of protein, fat, and carbohydrate of Japanese people in 2022 was within the Tentative Dietary Goal for Preventing Lifestyle- related Diseases (DG) established by the Ministry of Health, Labour and Welfare in Japan
or the Acceptable Macronutrient Distribution Ranges (AMDRs) set by the Institute of Medicine of the National Academy of Sciences in the U.S.
[27] | Institute of Medicine of the National Academy of Sciences. Food and Nutrition Board. Dietary Reference Intakes: The essential guide to nutrient requirements. Washington, D.C. The National Academy Press. Available from: https://www.nap.edu/catalog/11537.html (accessed 14 October 2021). |
[27]
. The Ministry of Agriculture, Forestry and Fisheries in Japan
has stated that the ideal balance of the caloric ratio of protein, fat and carbohydrate for healthy life is protein: 15%, fat: 25%, and carbohydrate: 60%. Since the Fat/Energy of Japanese people in 2022 was 29.1%, it seems better to decrease the Fat/Energy until 20-25%.