Objetives. To determine the correlation between prolactin levels and disease activity classified based on the Mexican lupus erythematosus disease systemic activity index (MEX SLEDAI). Methods. In this cross-sectional observational study, serum prolactin, age, sex, treatment, as well as manifestations of active disease were determined. Disease activity was evaluated using the Mexican Systemic Lupus Erythematosus Activity Index (MEX-SLEDAI). The correlation of MEX-SLEDAI with prolactin was determined using the Spearman correlation coefficient. The significance of differences between continuous variables was determined with the non-paired Student’s t test and the significance of differences between categorical variables was determined with Chi-square test. Results. 55 patients were included, 10 (18.1%) had MEX-SLEDAI ≥7 and 45 (81.8%) less than 7. A positive correlation was found with a Spearman rho 0.387 (p = 0.004) between the MEX-SLEDAI and the levels serum prolactin. Subjects with active disease and hyperprolactinemia had 80% manifestations at the renal level (p = 0.001). Conclusion. There is significant correlation between prolactin levels and disease activity. Hyperprolactinemia were detected in patients with renal activity as well as those with MEX-SLEDAI ≥7.
| Published in | International Journal of Biomedical Engineering and Clinical Science (Volume 7, Issue 4) |
| DOI | 10.11648/j.ijbecs.20210704.11 |
| Page(s) | 73-76 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Systemic Lupus Erythematosus, MEX-SLEDAI, Prolactin
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APA Style
Jorge Medina Castillo, María Azucena Ramos Sánchez, Ariana Maia Becerra Márquez. (2021). Prolactin as a Marker of Active Disease in Systemic Lupus Erythematosus. International Journal of Biomedical Engineering and Clinical Science, 7(4), 73-76. https://doi.org/10.11648/j.ijbecs.20210704.11
ACS Style
Jorge Medina Castillo; María Azucena Ramos Sánchez; Ariana Maia Becerra Márquez. Prolactin as a Marker of Active Disease in Systemic Lupus Erythematosus. Int. J. Biomed. Eng. Clin. Sci. 2021, 7(4), 73-76. doi: 10.11648/j.ijbecs.20210704.11
AMA Style
Jorge Medina Castillo, María Azucena Ramos Sánchez, Ariana Maia Becerra Márquez. Prolactin as a Marker of Active Disease in Systemic Lupus Erythematosus. Int J Biomed Eng Clin Sci. 2021;7(4):73-76. doi: 10.11648/j.ijbecs.20210704.11
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Download@article{10.11648/j.ijbecs.20210704.11,
author = {Jorge Medina Castillo and María Azucena Ramos Sánchez and Ariana Maia Becerra Márquez},
title = {Prolactin as a Marker of Active Disease in Systemic Lupus Erythematosus},
journal = {International Journal of Biomedical Engineering and Clinical Science},
volume = {7},
number = {4},
pages = {73-76},
doi = {10.11648/j.ijbecs.20210704.11},
url = {https://doi.org/10.11648/j.ijbecs.20210704.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbecs.20210704.11},
abstract = {Objetives. To determine the correlation between prolactin levels and disease activity classified based on the Mexican lupus erythematosus disease systemic activity index (MEX SLEDAI). Methods. In this cross-sectional observational study, serum prolactin, age, sex, treatment, as well as manifestations of active disease were determined. Disease activity was evaluated using the Mexican Systemic Lupus Erythematosus Activity Index (MEX-SLEDAI). The correlation of MEX-SLEDAI with prolactin was determined using the Spearman correlation coefficient. The significance of differences between continuous variables was determined with the non-paired Student’s t test and the significance of differences between categorical variables was determined with Chi-square test. Results. 55 patients were included, 10 (18.1%) had MEX-SLEDAI ≥7 and 45 (81.8%) less than 7. A positive correlation was found with a Spearman rho 0.387 (p = 0.004) between the MEX-SLEDAI and the levels serum prolactin. Subjects with active disease and hyperprolactinemia had 80% manifestations at the renal level (p = 0.001). Conclusion. There is significant correlation between prolactin levels and disease activity. Hyperprolactinemia were detected in patients with renal activity as well as those with MEX-SLEDAI ≥7.},
year = {2021}
}
TY - JOUR T1 - Prolactin as a Marker of Active Disease in Systemic Lupus Erythematosus AU - Jorge Medina Castillo AU - María Azucena Ramos Sánchez AU - Ariana Maia Becerra Márquez Y1 - 2021/11/19 PY - 2021 N1 - https://doi.org/10.11648/j.ijbecs.20210704.11 DO - 10.11648/j.ijbecs.20210704.11 T2 - International Journal of Biomedical Engineering and Clinical Science JF - International Journal of Biomedical Engineering and Clinical Science JO - International Journal of Biomedical Engineering and Clinical Science SP - 73 EP - 76 PB - Science Publishing Group SN - 2472-1301 UR - https://doi.org/10.11648/j.ijbecs.20210704.11 AB - Objetives. To determine the correlation between prolactin levels and disease activity classified based on the Mexican lupus erythematosus disease systemic activity index (MEX SLEDAI). Methods. In this cross-sectional observational study, serum prolactin, age, sex, treatment, as well as manifestations of active disease were determined. Disease activity was evaluated using the Mexican Systemic Lupus Erythematosus Activity Index (MEX-SLEDAI). The correlation of MEX-SLEDAI with prolactin was determined using the Spearman correlation coefficient. The significance of differences between continuous variables was determined with the non-paired Student’s t test and the significance of differences between categorical variables was determined with Chi-square test. Results. 55 patients were included, 10 (18.1%) had MEX-SLEDAI ≥7 and 45 (81.8%) less than 7. A positive correlation was found with a Spearman rho 0.387 (p = 0.004) between the MEX-SLEDAI and the levels serum prolactin. Subjects with active disease and hyperprolactinemia had 80% manifestations at the renal level (p = 0.001). Conclusion. There is significant correlation between prolactin levels and disease activity. Hyperprolactinemia were detected in patients with renal activity as well as those with MEX-SLEDAI ≥7. VL - 7 IS - 4 ER -
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