Therapeutic Efficacy of Albendazole and Tetraclozan Against Gastrointestinal Worms in Crossbred Cows of HARC, Welmera District, Central Ethiopia

Beksisa Urge; Tamirat Seyoum; Temesgen Kassa; Markos Tadele; Fekadu Gutema; Neima Arebu; Ulfina Galmessa; Million Tadese

doi:doi:10.11648/j.ijbecs.20210704.14

Therapeutic Efficacy of Albendazole and Tetraclozan Against Gastrointestinal Worms in Crossbred Cows of HARC, Welmera District, Central Ethiopia

Beksisa Urge, Tamirat Seyoum, Temesgen Kassa, Markos Tadele, Fekadu Gutema, Neima Arebu, Ulfina Galmessa, Million Tadese

Published in International Journal of Biomedical Engineering and Clinical Science (Volume 7, Issue 4)

Received: 20 October 2021 Accepted: 24 November 2021 Published: 24 November 2021

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Abstract

Gastrointestinal parasites are economically important in the dairy industry. A study was carried out to evaluate the therapeutic efficacy of anthelmintic drugs (Tetraclozan 3400 mg and Albendazole 2500mg) for the treatment of GIT worms in cross-bred cows at Holeta research center. A total of sixty crossbred cows were purposively screened and divided into three groups for the current study. The first groups served as untreated control, the second and third groups were treated with Albendazole and Tetraclozan drugs respectively. Moreover, fecal samples were collected before and after treatment to count the eggs per gram (EPG) of feces and to evaluate drug efficacy percentage. Efficacy for each anthelmintic was determined by the Fecal Egg Count Reduction Test (FECRT). The mean EPG count before and after treatment with Tetraclozan drug on 0. 14^th and 21^st days was 520±102.1, 100±54.6 and 15±6.7 respectively whereas the mean EPG count on 0, 14^th and 21^st days before and after treatment with Albendazole drug was 450±127.2, 150±46.2 and 20±6.8 respectively. The overall percentage efficacy of Tetraclozan and Albendazole drugs were 97.11 and 95.5 percent respectively. The study indicated that the two anthelmintic drugs were efficacious against worm infection and thus, leads to reduction in EPG count. It is important to explore the detailed pharmacokinetic and toxic effects of these drugs for wide therapeutic uses in animals. It is also recommended that the clinical responses of GIT helminthes to prophylactic and therapeutic drugs need to be periodically monitored in the farms and further introduced to smallholder farmers.

Published in	International Journal of Biomedical Engineering and Clinical Science (Volume 7, Issue 4)
DOI	10.11648/j.ijbecs.20210704.14
Page(s)	86-90
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Anthelmintic, Albendazole, EPG, Therapeutic, Efficacy, Treatment, Tetraclozan

References

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APA Style

Beksisa Urge, Tamirat Seyoum, Temesgen Kassa, Markos Tadele, Fekadu Gutema, et al. (2021). Therapeutic Efficacy of Albendazole and Tetraclozan Against Gastrointestinal Worms in Crossbred Cows of HARC, Welmera District, Central Ethiopia. International Journal of Biomedical Engineering and Clinical Science, 7(4), 86-90. https://doi.org/10.11648/j.ijbecs.20210704.14

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ACS Style

Beksisa Urge; Tamirat Seyoum; Temesgen Kassa; Markos Tadele; Fekadu Gutema, et al. Therapeutic Efficacy of Albendazole and Tetraclozan Against Gastrointestinal Worms in Crossbred Cows of HARC, Welmera District, Central Ethiopia. Int. J. Biomed. Eng. Clin. Sci. 2021, 7(4), 86-90. doi: 10.11648/j.ijbecs.20210704.14

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AMA Style

Beksisa Urge, Tamirat Seyoum, Temesgen Kassa, Markos Tadele, Fekadu Gutema, et al. Therapeutic Efficacy of Albendazole and Tetraclozan Against Gastrointestinal Worms in Crossbred Cows of HARC, Welmera District, Central Ethiopia. Int J Biomed Eng Clin Sci. 2021;7(4):86-90. doi: 10.11648/j.ijbecs.20210704.14

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@article{10.11648/j.ijbecs.20210704.14,
  author = {Beksisa Urge and Tamirat Seyoum and Temesgen Kassa and Markos Tadele and Fekadu Gutema and Neima Arebu and Ulfina Galmessa and Million Tadese},
  title = {Therapeutic Efficacy of Albendazole and Tetraclozan Against Gastrointestinal Worms in Crossbred Cows of HARC, Welmera District, Central Ethiopia},
  journal = {International Journal of Biomedical Engineering and Clinical Science},
  volume = {7},
  number = {4},
  pages = {86-90},
  doi = {10.11648/j.ijbecs.20210704.14},
  url = {https://doi.org/10.11648/j.ijbecs.20210704.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbecs.20210704.14},
  abstract = {Gastrointestinal parasites are economically important in the dairy industry. A study was carried out to evaluate the therapeutic efficacy of anthelmintic drugs (Tetraclozan 3400 mg and Albendazole 2500mg) for the treatment of GIT worms in cross-bred cows at Holeta research center. A total of sixty crossbred cows were purposively screened and divided into three groups for the current study. The first groups served as untreated control, the second and third groups were treated with Albendazole and Tetraclozan drugs respectively. Moreover, fecal samples were collected before and after treatment to count the eggs per gram (EPG) of feces and to evaluate drug efficacy percentage. Efficacy for each anthelmintic was determined by the Fecal Egg Count Reduction Test (FECRT). The mean EPG count before and after treatment with Tetraclozan drug on 0. 14th and 21st days was 520±102.1, 100±54.6 and 15±6.7 respectively whereas the mean EPG count on 0, 14th and 21st days before and after treatment with Albendazole drug was 450±127.2, 150±46.2 and 20±6.8 respectively. The overall percentage efficacy of Tetraclozan and Albendazole drugs were 97.11 and 95.5 percent respectively. The study indicated that the two anthelmintic drugs were efficacious against worm infection and thus, leads to reduction in EPG count. It is important to explore the detailed pharmacokinetic and toxic effects of these drugs for wide therapeutic uses in animals. It is also recommended that the clinical responses of GIT helminthes to prophylactic and therapeutic drugs need to be periodically monitored in the farms and further introduced to smallholder farmers.},
 year = {2021}
}

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TY  - JOUR
T1  - Therapeutic Efficacy of Albendazole and Tetraclozan Against Gastrointestinal Worms in Crossbred Cows of HARC, Welmera District, Central Ethiopia
AU  - Beksisa Urge
AU  - Tamirat Seyoum
AU  - Temesgen Kassa
AU  - Markos Tadele
AU  - Fekadu Gutema
AU  - Neima Arebu
AU  - Ulfina Galmessa
AU  - Million Tadese
Y1  - 2021/11/24
PY  - 2021
N1  - https://doi.org/10.11648/j.ijbecs.20210704.14
DO  - 10.11648/j.ijbecs.20210704.14
T2  - International Journal of Biomedical Engineering and Clinical Science
JF  - International Journal of Biomedical Engineering and Clinical Science
JO  - International Journal of Biomedical Engineering and Clinical Science
SP  - 86
EP  - 90
PB  - Science Publishing Group
SN  - 2472-1301
UR  - https://doi.org/10.11648/j.ijbecs.20210704.14
AB  - Gastrointestinal parasites are economically important in the dairy industry. A study was carried out to evaluate the therapeutic efficacy of anthelmintic drugs (Tetraclozan 3400 mg and Albendazole 2500mg) for the treatment of GIT worms in cross-bred cows at Holeta research center. A total of sixty crossbred cows were purposively screened and divided into three groups for the current study. The first groups served as untreated control, the second and third groups were treated with Albendazole and Tetraclozan drugs respectively. Moreover, fecal samples were collected before and after treatment to count the eggs per gram (EPG) of feces and to evaluate drug efficacy percentage. Efficacy for each anthelmintic was determined by the Fecal Egg Count Reduction Test (FECRT). The mean EPG count before and after treatment with Tetraclozan drug on 0. 14th and 21st days was 520±102.1, 100±54.6 and 15±6.7 respectively whereas the mean EPG count on 0, 14th and 21st days before and after treatment with Albendazole drug was 450±127.2, 150±46.2 and 20±6.8 respectively. The overall percentage efficacy of Tetraclozan and Albendazole drugs were 97.11 and 95.5 percent respectively. The study indicated that the two anthelmintic drugs were efficacious against worm infection and thus, leads to reduction in EPG count. It is important to explore the detailed pharmacokinetic and toxic effects of these drugs for wide therapeutic uses in animals. It is also recommended that the clinical responses of GIT helminthes to prophylactic and therapeutic drugs need to be periodically monitored in the farms and further introduced to smallholder farmers.
VL  - 7
IS  - 4
ER  -

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Author Information

Beksisa Urge

Ethiopian Institute of Agricultural Research, Holeta Research Center, Holeta, Ethiopia
Tamirat Seyoum

Ethiopian Institute of Agricultural Research, Holeta Research Center, Holeta, Ethiopia
Temesgen Kassa

Ethiopian Institute of Agricultural Research, Holeta Research Center, Holeta, Ethiopia
Markos Tadele

Ethiopian Institute of Agricultural Research, Holeta Research Center, Holeta, Ethiopia
Fekadu Gutema

Ethiopian Institute of Agricultural Research, Holeta Research Center, Holeta, Ethiopia
Neima Arebu

Ethiopian Institute of Agricultural Research, Holeta Research Center, Holeta, Ethiopia
Ulfina Galmessa

Ethiopian Institute of Agricultural Research, Holeta Research Center, Holeta, Ethiopia
Million Tadese

Ethiopian Institute of Agricultural Research, Holeta Research Center, Holeta, Ethiopia

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Plain Text BibTeX RIS

APA Style

Beksisa Urge, Tamirat Seyoum, Temesgen Kassa, Markos Tadele, Fekadu Gutema, et al. (2021). Therapeutic Efficacy of Albendazole and Tetraclozan Against Gastrointestinal Worms in Crossbred Cows of HARC, Welmera District, Central Ethiopia. International Journal of Biomedical Engineering and Clinical Science, 7(4), 86-90. https://doi.org/10.11648/j.ijbecs.20210704.14

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ACS Style

Beksisa Urge; Tamirat Seyoum; Temesgen Kassa; Markos Tadele; Fekadu Gutema, et al. Therapeutic Efficacy of Albendazole and Tetraclozan Against Gastrointestinal Worms in Crossbred Cows of HARC, Welmera District, Central Ethiopia. Int. J. Biomed. Eng. Clin. Sci. 2021, 7(4), 86-90. doi: 10.11648/j.ijbecs.20210704.14

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AMA Style

Beksisa Urge, Tamirat Seyoum, Temesgen Kassa, Markos Tadele, Fekadu Gutema, et al. Therapeutic Efficacy of Albendazole and Tetraclozan Against Gastrointestinal Worms in Crossbred Cows of HARC, Welmera District, Central Ethiopia. Int J Biomed Eng Clin Sci. 2021;7(4):86-90. doi: 10.11648/j.ijbecs.20210704.14

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@article{10.11648/j.ijbecs.20210704.14,
  author = {Beksisa Urge and Tamirat Seyoum and Temesgen Kassa and Markos Tadele and Fekadu Gutema and Neima Arebu and Ulfina Galmessa and Million Tadese},
  title = {Therapeutic Efficacy of Albendazole and Tetraclozan Against Gastrointestinal Worms in Crossbred Cows of HARC, Welmera District, Central Ethiopia},
  journal = {International Journal of Biomedical Engineering and Clinical Science},
  volume = {7},
  number = {4},
  pages = {86-90},
  doi = {10.11648/j.ijbecs.20210704.14},
  url = {https://doi.org/10.11648/j.ijbecs.20210704.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbecs.20210704.14},
  abstract = {Gastrointestinal parasites are economically important in the dairy industry. A study was carried out to evaluate the therapeutic efficacy of anthelmintic drugs (Tetraclozan 3400 mg and Albendazole 2500mg) for the treatment of GIT worms in cross-bred cows at Holeta research center. A total of sixty crossbred cows were purposively screened and divided into three groups for the current study. The first groups served as untreated control, the second and third groups were treated with Albendazole and Tetraclozan drugs respectively. Moreover, fecal samples were collected before and after treatment to count the eggs per gram (EPG) of feces and to evaluate drug efficacy percentage. Efficacy for each anthelmintic was determined by the Fecal Egg Count Reduction Test (FECRT). The mean EPG count before and after treatment with Tetraclozan drug on 0. 14th and 21st days was 520±102.1, 100±54.6 and 15±6.7 respectively whereas the mean EPG count on 0, 14th and 21st days before and after treatment with Albendazole drug was 450±127.2, 150±46.2 and 20±6.8 respectively. The overall percentage efficacy of Tetraclozan and Albendazole drugs were 97.11 and 95.5 percent respectively. The study indicated that the two anthelmintic drugs were efficacious against worm infection and thus, leads to reduction in EPG count. It is important to explore the detailed pharmacokinetic and toxic effects of these drugs for wide therapeutic uses in animals. It is also recommended that the clinical responses of GIT helminthes to prophylactic and therapeutic drugs need to be periodically monitored in the farms and further introduced to smallholder farmers.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Therapeutic Efficacy of Albendazole and Tetraclozan Against Gastrointestinal Worms in Crossbred Cows of HARC, Welmera District, Central Ethiopia
AU  - Beksisa Urge
AU  - Tamirat Seyoum
AU  - Temesgen Kassa
AU  - Markos Tadele
AU  - Fekadu Gutema
AU  - Neima Arebu
AU  - Ulfina Galmessa
AU  - Million Tadese
Y1  - 2021/11/24
PY  - 2021
N1  - https://doi.org/10.11648/j.ijbecs.20210704.14
DO  - 10.11648/j.ijbecs.20210704.14
T2  - International Journal of Biomedical Engineering and Clinical Science
JF  - International Journal of Biomedical Engineering and Clinical Science
JO  - International Journal of Biomedical Engineering and Clinical Science
SP  - 86
EP  - 90
PB  - Science Publishing Group
SN  - 2472-1301
UR  - https://doi.org/10.11648/j.ijbecs.20210704.14
AB  - Gastrointestinal parasites are economically important in the dairy industry. A study was carried out to evaluate the therapeutic efficacy of anthelmintic drugs (Tetraclozan 3400 mg and Albendazole 2500mg) for the treatment of GIT worms in cross-bred cows at Holeta research center. A total of sixty crossbred cows were purposively screened and divided into three groups for the current study. The first groups served as untreated control, the second and third groups were treated with Albendazole and Tetraclozan drugs respectively. Moreover, fecal samples were collected before and after treatment to count the eggs per gram (EPG) of feces and to evaluate drug efficacy percentage. Efficacy for each anthelmintic was determined by the Fecal Egg Count Reduction Test (FECRT). The mean EPG count before and after treatment with Tetraclozan drug on 0. 14th and 21st days was 520±102.1, 100±54.6 and 15±6.7 respectively whereas the mean EPG count on 0, 14th and 21st days before and after treatment with Albendazole drug was 450±127.2, 150±46.2 and 20±6.8 respectively. The overall percentage efficacy of Tetraclozan and Albendazole drugs were 97.11 and 95.5 percent respectively. The study indicated that the two anthelmintic drugs were efficacious against worm infection and thus, leads to reduction in EPG count. It is important to explore the detailed pharmacokinetic and toxic effects of these drugs for wide therapeutic uses in animals. It is also recommended that the clinical responses of GIT helminthes to prophylactic and therapeutic drugs need to be periodically monitored in the farms and further introduced to smallholder farmers.
VL  - 7
IS  - 4
ER  -

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