Foot-and-mouth disease (FMD) is a viral disease that primarily affects animals with cloven hooves. It is a highly contagious disease and difficult to control due to its complex epidemiological nature and poor diagnostic facilities. Thus, this paper aimed to review the epidemiology of FMD, and its economic impact on farmers, discuss the available diagnostic, and prevention and control methods that can be practiced. Foot-and-mouth disease virus (FMDV) is the causative agent of FMD, and it is a single-stranded RNA virus with a positive sense that belongs to the genus Aphthovirus and the family Picornaviridae. The virus has seven serologically and genetically distinct serotypes, namely O, A, C, Asia1, SAT1, SAT2, and SAT3, as well as over 60 subtypes. The virus is inactivated by heat, UV radiation, pH levels below 6.5 or above 9, gamma irradiation, chemicals, and disinfectants, but it is almost indefinitely stable at temperatures below freezing point. The tongue, dental pad, gums, cheek, hard and soft palates, lips, nostrils, muzzle, interdigital space (between the hooves), and a coronary band of affected animals develop vesicular lesions. Viruses can be spread orally or via the respiratory tract. FMD is diagnosed based on clinical signs, and using epidemiological methods and laboratory techniques. FMD causes severe economic losses as a result of high morbidity associated with outbreak occurrences, limiting the introduction of improved production technologies in the area, restrictions on international trade, and costs associated with the application of control measures. Some of the control and prevention methods for FMD are vaccination, animal movement control, physical separation from wildlife, and symptomatic treatment. But due to its complex epidemiological nature, limited diagnostic capabilities, and no cross-immunity between strains, FMD was difficult to control. Therefore, awareness creation among animal owners about the disease, and possible prevention and control methods that can be practiced is required. And also, research in the development of a multivalent and protective vaccine is recommended.
| Published in | International Journal of Biomedical Engineering and Clinical Science (Volume 9, Issue 3) |
| DOI | 10.11648/j.ijbecs.20230903.12 |
| Page(s) | 38-46 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Diagnosis, Epidemiology, Foot-and-Mouth Disease
| [1] | Admassu, B., Getnet, K., Shite, A. and Mohammed, S., 2015. Review on foot and mouth disease: distribution and economic significance. Academic Journal of Animal Diseases. 4 (3): 160-169. DOI: 10.5829/idosi.ajad.2015.4.3.95165. |
| [2] | Park, M. E., Lee, S. Y., Kim, R. H., Ko, M. K., Park, J. N., Lee, K. N., Kim, S. M., Choi, J. H., You, S. H., Kim, B. and Lee, J. S., 2016. Altered adjuvant of foot-and-mouth disease vaccine improves immune response and protection from virus challenge. Trials in Vaccinology, 5 (1): 97-104. http://dx.doi.org/10.1016/j.trivac.2016.04.006. |
| [3] | Woldemariyam, F. T., De Vleeschauwer, A., Hundessa, N., Muluneh, A., Gizaw, D., Tinel, S., De Clercq, K., Lefebvre, D. and Paeshuyse, J., 2021. Risk Factor Assessment, Sero-Prevalence, and Genotyping of the Virus That Causes Foot-and-Mouth Disease on Commercial Farms in Ethiopia from October 2018 to February 2020. Agriculture, 12 (1): 1-49. DOI: 10.3390/agriculture12010049. |
| [4] | OIE, P. B., 2009. NB: Version adapted by the World Assembly of Delegates of the Office International des epizooties. Paris, France. |
| [5] | Tadesse, B., Tesfahun, A., Molla, W., Demisse, E. and Jemberu, W. T. (2020): Foot and mouth disease outbreak investigation and estimation of its economic impact in selected districts in northwest Ethiopia. Veterinary Medicine and Science, 6 (1): 122-132. DOI: 10.1002/vms3.208. |
| [6] | Aman, E., Molla, W., Gebreegizabher, Z. and Jemberu, W. T. (2020): Spatial and temporal distribution of foot and mouth disease outbreaks in Amhara region of Ethiopia in the period 1999 to 2016. BMC Veterinary Research, 16 (1): 1-8. https://doi.org/10.1186/s12917-020-02411-6. |
| [7] | Greger, M. 2007. The long haul: risks associated with livestock transport. Biosecurity and bioterrorism: biodefense strategy, practice, and science, 5 (4): 301-312. |
| [8] | Tadesse, B., Molla, W., Mengsitu, A. and Jemberu, W. T. (2019): Transmission dynamics of foot and mouth disease in selected outbreak areas of northwest Ethiopia. Epidemiology & Infection, 147: e189. DOI: 10.1017/S0950268819000803. |
| [9] | Hindson, B. J., Reid, S. M., Baker, B. R., Ebert, K., Ferris, N. P., Tammero, L. F. B., Lenhoff, R. J., Naraghi-Arani, P., Vitalis, E. A., Slezak, T. R. and Hullinger, P. J., 2008: Diagnostic evaluation of multiplexed reverse transcription-PCR microsphere array assay for detection of foot-and-mouth and look-alike disease viruses. Journal of Clinical Microbiology, 46 (3), pp. 1081-1089. |
| [10] | Paixão, T. A., Neta, A. V. C., Paiva, N., Reis, J. R., Barbosa, M. S., Serra, C. V., Silva, R. R., Beckham, T. R., Martin, B. M., Clarke, N. P. and Adams, L. G. (2008): Diagnosis of foot-and-mouth disease by real-time reverse transcription polymerase chain reaction under field conditions in Brazil. BMC Veterinary Research, 4 (53): 1-6. DOI: 10.1186/1746-6148-4-53. |
| [11] | Jemberu, W. T. (2016): Bioeconomic modeling of foot and mouth disease and its control in Ethiopia. PhD thesis, Wageningen University, Wageningen. |
| [12] | Shimels, T. Y. (2019): Antigen detection and molecular characterization of foot and mouth disease virus from outbreak cases in Ethiopia. MVSc thesis, College of Veterinary Medicine and Agriculture, Addis Ababa University, Ethiopia. |
| [13] | Longjam, N., Deb, R., Sarmah, A. K., Tayo, T., Awachat, V. B. and Saxena, V. K. (2011): A brief review on diagnosis of foot-and-mouth disease of livestock: conventional to molecular tools. Veterinary Medicine International, 2011: 232, 1-17. DOI: 10.4061/2011/905768. |
| [14] | Menda, S., Jenberie, S., Negussie, H., Ayelet, G. and Amasalu, K. (2014): Molecular epidemiology of foot and mouth disease Virus Outbreaks in Ethiopia in 2011/2012. Academic Journal of Animal Diseases, 3 (2): 8-16. DOI: 10.5829/idosi.ajad.2014.3.2.85169. |
| [15] | Mahy, B. W. (2005): Introduction and history of foot-and-mouth disease virus. Curr. Top. Microbiol. Immunol., 288: 1-8. DOI: 10.1007/3-540-27109-0_1. |
| [16] | Chakraborty, S., Kumar, N., Dhama, K., Verma, A. K., Tiwari, R., Kumar, A., Kapoor, S. and Singh, S. V. (2014): Foot-and-mouth disease, an economically important disease of animals. Adv. Anim. Vet. Sci, 2 (2): 1-18. |
| [17] | Mishamo, S. I. (2016): Isolation, Molecular Characterization and Sero-prevalence study of foot-and-mouth disease virus circulating in central Ethiopia. MVSc thesis, College of Veterinary Medicine and Agriculture, Addis Ababa University, Ethiopia. |
| [18] | Wubshet, A. K., Dai, J., Li, Q. and Zhang, J. (2019): Review on outbreak dynamics, the endemic serotypes, and diversified topotypic profiles of foot and mouth disease virus isolates in Ethiopia from 2008 to 2018. Viruses, 11 (11): 1-17. https://doi.org/10.3390/v11111076. |
| [19] | Wondwossen T. (2017): Isolation, molecular characterization and vaccine matching of foot-and-mouth disease virus circulating in central Ethiopia. MVSc thesis, College of Veterinary Medicine and Agriculture, Addis Ababa University, Ethiopia. |
| [20] | Tesfaye, J. (2019): Review on the Epidemiology and Economic Impact of Foot and Mouth Disease in Ethiopia. Agricultural Journal, 14 (5): 79-93. DOI: 10.36478/aj.2019.79.93. |
| [21] | Klein, J. (2009): Understanding the molecular epidemiology of foot-and-mouth-disease virus. Infection, Genetics and Evolution, 9 (2): 153-161. DOI: 10.1016/j.meegid.2008.11.005. |
| [22] | Wernery, U. and Kinne, J. (2012): Foot and mouth disease and similar virus infections in camelids: a review. Rev. Sci. Tech., 31 (3): 907-918. DOI: 10.20506/rst.31.3.2160. |
| [23] | Leon, E. A. (2012): Foot-and-Mouth Disease in pigs: current epidemiological situation and control methods. Transboundary and emerging diseases, 59: 36-49. DOI: 10.1111/j.1865-1682.2011.01290.x. |
| [24] | Tesfaye, Y., Khan F. and Gelaye E. (2020): Molecular characterization of foot-and-mouth disease viruses collected from Northern and Central Ethiopia during the 2018 outbreak. Vet. World, 13 (3): 542–548. DOI: 10.14202/vetworld.2020.542-548. |
| [25] | Bayush, W. (2020): Isolation and molecular characterization of foot and mouth disease viruses in cattle from outbreaks occurred in different parts of Ethiopia. MVSc thesis, College of Veterinary Medicine and Agriculture, Addis Ababa University, Ethiopia. |
| [26] | Yan, H., Wang, J., Zhu, M., Miao, H., Peng, Z., Li, H. and Xin, A. (2017): Complete Genome Sequence of Foot-and-Mouth Disease Virus Serotype O Strain YNTBa from Yunnan Province of China. Genome announcements, 5 (22): e00393-17. DOI: 10.1128/genomeA.00393-17. |
| [27] | USDA (2020): The Foreign Animal Disease Preparedness and Response Plan, in: 4700, U. S. D. of A. (Ed.), Foot-and-Mouth Disease (FMD) Response Plan. Animal and Plant Health Inspection Service, United States, p3–46. |
| [28] | Bayissa, B., Ayelet, G., Kyule, M., Jibril, Y. and Gelaye, E. (2011): Study on seroprevalence, risk factors, and economic impact of foot-and-mouth disease in Borena pastoral and agro-pastoral system, southern Ethiopia. Tropical Animal Health and Production, 43 (4): 759-766. DOI: 10.1007/s11250-010-9728-6. |
| [29] | Souley Kouato, B., De Clercq, K., Abatih, E., Dal Pozzo, F., King, D. P., Thys, E., Marichatou, H. and Saegerman, C. (2018): Review of epidemiological risk models for foot-and-mouth disease: implications for prevention strategies with a focus on Africa. PLoS ONE, 13 (12): e0208296. https://doi.org/10.1371/journal.pone.0208296. |
| [30] | Al-Salihi, K. A. (2019): The epidemiology of foot-and-mouth disease outbreaks and its history in Iraq. Veterinary World, 12 (5): 706-712. |
| [31] | Verma A. K., Kumar A., Mahima and Sahzad (2012): Epidemiology and diagnosis of foot-and-mouth disease: A review. Indian Journal of Animal Sciences, 82 (6): 543-551. |
| [32] | Molla, B., Ayelet, G., Asfaw, Y., Jibril, Y. and Gelaye, E. (2013): Participatory epidemiology and associated risk factors of foot-and-mouth disease in cattle in South Omo zone, South-Western Ethiopia. Journal of Veterinary Medicine and Animal Health, 5 (11): 322-328. |
| [33] | Jamal, S. M. and Belsham, G. J. (2013): Foot-and-mouth disease: past, present and future. Veterinary Research, 44 (1): 1-14. http://www.veterinaryresearch.org/content/44/1/116 |
| [34] | Grubman, M. J. and Baxt, B. (2004): Foot-and-mouth disease. Clinical Microbiology Reviews, 17 (2): 465-493. DOI: 10.1128/CMR.17.2.465-493.2004. |
| [35] | Sharma, G. K., Mahajan, S., Matura, R., Subramaniam, S., Ranjan, R., Biswal, J., Rout, M., Mohapatra, J. K., Dash, B. B., Sanyal, A. and Pattnaik, B. (2015): Diagnostic assays developed for the control of foot-and-mouth disease in India. World Journal of Virology, 4 (3): 295-302. DOI: 10.5501/wjv.v4.i3.295. |
| [36] | Mahmoud, M. A. E., Ghazy, A. A., Shaapan, R. M. (2019): Diagnosis and Control of Foot and Mouth Disease (FMD) in Dairy Small Ruminants ; Sheep and Goats. International Journal of. Dairy Science, 14 (1): 45–52. DOI: 10.3923/ijds.2019.45.52. |
| [37] | EL-Shehawy, L., Abu-Elnaga, H., Abdel Atty, Ma, Fawzy, H., A.-W. (2011): Laboratory diagnosis of FMD using real-time RT-PCR in Egypt. Life Sci. J., 8: 384–387. |
| [38] | Tesfaye, Y. (2014): Isolation, Molecular characterization and vaccine matching of foot and mouth disease virus circulating in Ethiopia. MVSc thesis, College of Veterinary Medicine and Agriculture, Addis Ababa University, Ethiopia. |
| [39] | Fosgate, G. T. (2009): Practical sample size calculations for surveillance and diagnostic investigations. Journal of Veterinary Diagnostic Investigation, 21 (1): 3-14. DOI: 10.1177/104063870902100102. |
| [40] | Adege, H. and Masebo M. (2017): Assessment of the Major Animal Health Problems and its Economic Impact on Beef Cattle Export Industry at Adama Quarantine Station, Central Ethiopia. Int. J. Vet. Heal. Sci. Res. 5: 165–170. DOI: http://dx.doi.org/10.19070/2332-2748-1700034. |
| [41] | Hosamani, M., Basagoudanavar, S. H., Selvan, R. T., Das, V., Ngangom, P., Sreenivasa, B. P., Hegde, R. and Venkataramanan, R. (2015): A multi-species indirect ELISA for detection of non-structural protein 3ABC specific antibodies to foot-and-mouth disease virus. Archives of Virology, 160 (4): 937-944. DOI: 10.1007/s00705-015-2339-9. |
| [42] | Roche, S. E., Garner, M. G., Sanson, R. L., Cook, C., Birch, C., Backer, J. A., Dube, C., Patyk, K. A., Stevenson, M. A., Yu, Z. D., and Rawdon, T. G. (2015): Evaluating vaccination strategies to control the foot-and-mouth disease: a model comparison study. Epidemiology & Infection, 143 (6): 1256-1275. DOI: 10.1017/S0950268814001927. |
| [43] | Knight, T. J. D. and Rushton, J. (2013): The economic impacts of foot and mouth disease–What are they, how big are they and where do they occur? Preventive Veterinary Medicine, 112 (3-4): 161-173. DOI: 10.1016/j.prevetmed.2013.07.013. |
| [44] | Alemayehu, G., Zewde, G. and Admassu, B. (2014): Seroprevalence of foot and mouth disease (FMD) and associated economic impact on Central Ethiopian cattle feedlots. Journal of Veterinary Medicine and Animal Health, 6 (5): 154-158. DOI: 10.5897/JVMAH2013.0247. |
| [45] | Tadesse, B., Alamir, K. and Demssie, E. (2017): Review on the Control of Foot and Mouth Disease by Vaccination. International Journal of Basic and Applied Virology, 6 (2): 09-18. DOI: 10.5829/idosi.ijbav.2017.09.18. |
| [46] | Akalu, B., (2017): Review on Common Impact and Management of Transboundary Animal Diseases. Juniper Online J. ImmunoVirol, 2: 1–7. DOI: 10.19080/JOJIV.2017.02.555583. |
| [47] | Sobrino, F., Sáiz, M., Jiménez-Clavero, M. A., Núñez, J. I., Rosas, M. F., Baranowski, E. and Ley, V. (2001): Foot-and-mouth disease virus: a long known virus, but a current threat. Veterinary Research, 32 (1): 1-30. DOI: 10.1051/vetres:2001106. |
| [48] | Yirgalem, M., Dawo, F., Gizaw, D., Mamo, B., Bilata, T. and Shegu, D. (2020): Phylogenetic and Sequence Variability Analyses of Vp1 Protein of Foot and Mouth Disease Viruses in Cattle in Amhara Region of Ethiopia. Researchsquare. 1-26. DOI: 10.21203/rs.2.20380/v1. |
APA Style
Betelihem Yirdaw, Dessie Abera. (2023). Epidemiology and Diagnostic Methods of Foot-and-Mouth Disease: A Review. International Journal of Biomedical Engineering and Clinical Science, 9(3), 38-46. https://doi.org/10.11648/j.ijbecs.20230903.12
ACS Style
Betelihem Yirdaw; Dessie Abera. Epidemiology and Diagnostic Methods of Foot-and-Mouth Disease: A Review. Int. J. Biomed. Eng. Clin. Sci. 2023, 9(3), 38-46. doi: 10.11648/j.ijbecs.20230903.12
AMA Style
Betelihem Yirdaw, Dessie Abera. Epidemiology and Diagnostic Methods of Foot-and-Mouth Disease: A Review. Int J Biomed Eng Clin Sci. 2023;9(3):38-46. doi: 10.11648/j.ijbecs.20230903.12
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Download@article{10.11648/j.ijbecs.20230903.12,
author = {Betelihem Yirdaw and Dessie Abera},
title = {Epidemiology and Diagnostic Methods of Foot-and-Mouth Disease: A Review},
journal = {International Journal of Biomedical Engineering and Clinical Science},
volume = {9},
number = {3},
pages = {38-46},
doi = {10.11648/j.ijbecs.20230903.12},
url = {https://doi.org/10.11648/j.ijbecs.20230903.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbecs.20230903.12},
abstract = {Foot-and-mouth disease (FMD) is a viral disease that primarily affects animals with cloven hooves. It is a highly contagious disease and difficult to control due to its complex epidemiological nature and poor diagnostic facilities. Thus, this paper aimed to review the epidemiology of FMD, and its economic impact on farmers, discuss the available diagnostic, and prevention and control methods that can be practiced. Foot-and-mouth disease virus (FMDV) is the causative agent of FMD, and it is a single-stranded RNA virus with a positive sense that belongs to the genus Aphthovirus and the family Picornaviridae. The virus has seven serologically and genetically distinct serotypes, namely O, A, C, Asia1, SAT1, SAT2, and SAT3, as well as over 60 subtypes. The virus is inactivated by heat, UV radiation, pH levels below 6.5 or above 9, gamma irradiation, chemicals, and disinfectants, but it is almost indefinitely stable at temperatures below freezing point. The tongue, dental pad, gums, cheek, hard and soft palates, lips, nostrils, muzzle, interdigital space (between the hooves), and a coronary band of affected animals develop vesicular lesions. Viruses can be spread orally or via the respiratory tract. FMD is diagnosed based on clinical signs, and using epidemiological methods and laboratory techniques. FMD causes severe economic losses as a result of high morbidity associated with outbreak occurrences, limiting the introduction of improved production technologies in the area, restrictions on international trade, and costs associated with the application of control measures. Some of the control and prevention methods for FMD are vaccination, animal movement control, physical separation from wildlife, and symptomatic treatment. But due to its complex epidemiological nature, limited diagnostic capabilities, and no cross-immunity between strains, FMD was difficult to control. Therefore, awareness creation among animal owners about the disease, and possible prevention and control methods that can be practiced is required. And also, research in the development of a multivalent and protective vaccine is recommended.},
year = {2023}
}
TY - JOUR T1 - Epidemiology and Diagnostic Methods of Foot-and-Mouth Disease: A Review AU - Betelihem Yirdaw AU - Dessie Abera Y1 - 2023/07/13 PY - 2023 N1 - https://doi.org/10.11648/j.ijbecs.20230903.12 DO - 10.11648/j.ijbecs.20230903.12 T2 - International Journal of Biomedical Engineering and Clinical Science JF - International Journal of Biomedical Engineering and Clinical Science JO - International Journal of Biomedical Engineering and Clinical Science SP - 38 EP - 46 PB - Science Publishing Group SN - 2472-1301 UR - https://doi.org/10.11648/j.ijbecs.20230903.12 AB - Foot-and-mouth disease (FMD) is a viral disease that primarily affects animals with cloven hooves. It is a highly contagious disease and difficult to control due to its complex epidemiological nature and poor diagnostic facilities. Thus, this paper aimed to review the epidemiology of FMD, and its economic impact on farmers, discuss the available diagnostic, and prevention and control methods that can be practiced. Foot-and-mouth disease virus (FMDV) is the causative agent of FMD, and it is a single-stranded RNA virus with a positive sense that belongs to the genus Aphthovirus and the family Picornaviridae. The virus has seven serologically and genetically distinct serotypes, namely O, A, C, Asia1, SAT1, SAT2, and SAT3, as well as over 60 subtypes. The virus is inactivated by heat, UV radiation, pH levels below 6.5 or above 9, gamma irradiation, chemicals, and disinfectants, but it is almost indefinitely stable at temperatures below freezing point. The tongue, dental pad, gums, cheek, hard and soft palates, lips, nostrils, muzzle, interdigital space (between the hooves), and a coronary band of affected animals develop vesicular lesions. Viruses can be spread orally or via the respiratory tract. FMD is diagnosed based on clinical signs, and using epidemiological methods and laboratory techniques. FMD causes severe economic losses as a result of high morbidity associated with outbreak occurrences, limiting the introduction of improved production technologies in the area, restrictions on international trade, and costs associated with the application of control measures. Some of the control and prevention methods for FMD are vaccination, animal movement control, physical separation from wildlife, and symptomatic treatment. But due to its complex epidemiological nature, limited diagnostic capabilities, and no cross-immunity between strains, FMD was difficult to control. Therefore, awareness creation among animal owners about the disease, and possible prevention and control methods that can be practiced is required. And also, research in the development of a multivalent and protective vaccine is recommended. VL - 9 IS - 3 ER -
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