Background: Drug induced thrombocytopenia is associated with several usual drugs. It usually presents with stunning, chills, fever, nausea and vomiting followed by the occurrence of petechial hemorrhages and bruising. Fluoroquinolones which are a widely used antibiotics are not recognized to be common offenders. Ciprofloxacin is generally considered a safe and well-tolerated drug. It has a large spectrum and it is one of the most widely prescribed antibiotics in a broad range of infections. Purpose: Only a few cases of fluoroquinolone-induced thrombocytopenia have been reported thus this side effect is largely unknown by clinicians. Case: We report the case of a 55 year old women with a bilateral percutaneous nephrostomy secondary to a radiation-induced cystitis. She was known for chronic kidney disease KDIGO IIIb and arterial hypertension. She suffered severe thrombocytopenia on three different occasions while treated by ciprofloxacin for urinary infections. She remained asymptomatic although her platelet count dropped as low as 6×103/µL. Each time, her platelet count recovered within a few days after ciprofloxacin interruption. Conclusion: Clinicians should be aware of the possible relationship between thrombocytopenia and ciprofloxacin. In depth work-up should be carried out to assess relationship between a newly introduced drug and a serious clinical or biological side effect.
| Published in | International Journal of Infectious Diseases and Therapy (Volume 8, Issue 3) |
| DOI | 10.11648/j.ijidt.20230803.17 |
| Page(s) | 122-126 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Ciprofloxacin, Thrombocytopenia, Drug Induced Toxicity, Antibiotic Toxicity, Hematologic Toxicity
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APA Style
Alexis Orman, Mohamed Tayeb Salaouatchi, Anne Demulder, Juliette Coryn, Victor Fernando Calderon Plazarte, et al. (2023). Ciprofloxacin-Induced Thrombocytopenia: A Case Report and Literature Review. International Journal of Infectious Diseases and Therapy, 8(3), 122-126. https://doi.org/10.11648/j.ijidt.20230803.17
ACS Style
Alexis Orman; Mohamed Tayeb Salaouatchi; Anne Demulder; Juliette Coryn; Victor Fernando Calderon Plazarte, et al. Ciprofloxacin-Induced Thrombocytopenia: A Case Report and Literature Review. Int. J. Infect. Dis. Ther. 2023, 8(3), 122-126. doi: 10.11648/j.ijidt.20230803.17
AMA Style
Alexis Orman, Mohamed Tayeb Salaouatchi, Anne Demulder, Juliette Coryn, Victor Fernando Calderon Plazarte, et al. Ciprofloxacin-Induced Thrombocytopenia: A Case Report and Literature Review. Int J Infect Dis Ther. 2023;8(3):122-126. doi: 10.11648/j.ijidt.20230803.17
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Download@article{10.11648/j.ijidt.20230803.17,
author = {Alexis Orman and Mohamed Tayeb Salaouatchi and Anne Demulder and Juliette Coryn and Victor Fernando Calderon Plazarte and André Efira and Philippe Clevenbergh},
title = {Ciprofloxacin-Induced Thrombocytopenia: A Case Report and Literature Review},
journal = {International Journal of Infectious Diseases and Therapy},
volume = {8},
number = {3},
pages = {122-126},
doi = {10.11648/j.ijidt.20230803.17},
url = {https://doi.org/10.11648/j.ijidt.20230803.17},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijidt.20230803.17},
abstract = {Background: Drug induced thrombocytopenia is associated with several usual drugs. It usually presents with stunning, chills, fever, nausea and vomiting followed by the occurrence of petechial hemorrhages and bruising. Fluoroquinolones which are a widely used antibiotics are not recognized to be common offenders. Ciprofloxacin is generally considered a safe and well-tolerated drug. It has a large spectrum and it is one of the most widely prescribed antibiotics in a broad range of infections. Purpose: Only a few cases of fluoroquinolone-induced thrombocytopenia have been reported thus this side effect is largely unknown by clinicians. Case: We report the case of a 55 year old women with a bilateral percutaneous nephrostomy secondary to a radiation-induced cystitis. She was known for chronic kidney disease KDIGO IIIb and arterial hypertension. She suffered severe thrombocytopenia on three different occasions while treated by ciprofloxacin for urinary infections. She remained asymptomatic although her platelet count dropped as low as 6×103/µL. Each time, her platelet count recovered within a few days after ciprofloxacin interruption. Conclusion: Clinicians should be aware of the possible relationship between thrombocytopenia and ciprofloxacin. In depth work-up should be carried out to assess relationship between a newly introduced drug and a serious clinical or biological side effect.},
year = {2023}
}
TY - JOUR T1 - Ciprofloxacin-Induced Thrombocytopenia: A Case Report and Literature Review AU - Alexis Orman AU - Mohamed Tayeb Salaouatchi AU - Anne Demulder AU - Juliette Coryn AU - Victor Fernando Calderon Plazarte AU - André Efira AU - Philippe Clevenbergh Y1 - 2023/09/13 PY - 2023 N1 - https://doi.org/10.11648/j.ijidt.20230803.17 DO - 10.11648/j.ijidt.20230803.17 T2 - International Journal of Infectious Diseases and Therapy JF - International Journal of Infectious Diseases and Therapy JO - International Journal of Infectious Diseases and Therapy SP - 122 EP - 126 PB - Science Publishing Group SN - 2578-966X UR - https://doi.org/10.11648/j.ijidt.20230803.17 AB - Background: Drug induced thrombocytopenia is associated with several usual drugs. It usually presents with stunning, chills, fever, nausea and vomiting followed by the occurrence of petechial hemorrhages and bruising. Fluoroquinolones which are a widely used antibiotics are not recognized to be common offenders. Ciprofloxacin is generally considered a safe and well-tolerated drug. It has a large spectrum and it is one of the most widely prescribed antibiotics in a broad range of infections. Purpose: Only a few cases of fluoroquinolone-induced thrombocytopenia have been reported thus this side effect is largely unknown by clinicians. Case: We report the case of a 55 year old women with a bilateral percutaneous nephrostomy secondary to a radiation-induced cystitis. She was known for chronic kidney disease KDIGO IIIb and arterial hypertension. She suffered severe thrombocytopenia on three different occasions while treated by ciprofloxacin for urinary infections. She remained asymptomatic although her platelet count dropped as low as 6×103/µL. Each time, her platelet count recovered within a few days after ciprofloxacin interruption. Conclusion: Clinicians should be aware of the possible relationship between thrombocytopenia and ciprofloxacin. In depth work-up should be carried out to assess relationship between a newly introduced drug and a serious clinical or biological side effect. VL - 8 IS - 3 ER -
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