Types of Tuberculosis and Factors Associated with Treatment Outcome and Mortality in the Obuasi Municipality of Ashanti Region, Ghana

Daniel Yeboah Asiamah; Georgina Frimpong Siraa; Obed Kumi; Williams Domechele; Philip Teg-Nefaah Tabong

doi:doi:10.11648/j.ijidt.20230804.11

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Types of Tuberculosis and Factors Associated with Treatment Outcome and Mortality in the Obuasi Municipality of Ashanti Region, Ghana

Daniel Yeboah Asiamah, Georgina Frimpong Siraa, Obed Kumi, Williams Domechele, Philip Teg-Nefaah Tabong

Published in International Journal of Infectious Diseases and Therapy (Volume 8, Issue 4)

Received: 4 September 2023 Accepted: 19 September 2023 Published: 8 October 2023

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Abstract

Introduction: Tuberculosis (TB) affects all persons in all countries of the world. Treatment outcomes remain a global indicator for measuring a country’s progress towards elimination of tuberculosis. Objective: The study was conducted to determine the distribution of TB by type and factors associated with treatment outcomes and mortality among a cohort of patients who received treatment for this disease between January 2015-December 2017 in the Obuasi municipality of Ghana. Results: The distribution of TB type were as follows: smear positive pulmonary TB (SPPTB), 50.0%, clinically diagnosed (smear negative) pulmonary TB 46.2%, extra-pulmonary TB 3.8% and 114 (19.83%) TB+HIV comorbidity. About 157 (27.30%) of TB patients were not screened for HIV. Successful treatment outcome rate was 77.20%. Unsuccessful treatment outcome rate was 22.80%; 7.90% defaulted, whereas 13.77% died, 0.90% treatment failure and 0.23% transferred out. In multivariable analysis, TB-HIV co-morbidity (aOR=3.37, 95% CI=1.50-7.57, p=0.003) was associated with unsuccessful treatment outcome and mortality (aOR=3.38, 95% CI=1.60-7.12, p=0.001). HIV infection reduced the likelihood of patient having successful treatment outcome whilst increasing the risk of mortality. Noncompliance with enhanced surveillance of screening all TB patients for HIV was common.

Published in	International Journal of Infectious Diseases and Therapy (Volume 8, Issue 4)
DOI	10.11648/j.ijidt.20230804.11
Page(s)	127-131
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Factors, Tuberculosis, Types, TB-HIV Co-morbidity, Treatment Outcomes, Mortality, Ghana

References

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[12]	Guiastrennec B, Ramachandran G, Karlsson MO, Kumar AKH, Bhavani PK, Gangadevi NP, et al. Suboptimal Antituberculosis Drug Concentrations and Outcomes in Small and HIV-Coinfected Children in India: Recommendations for Dose Modifications. Clin Pharmacol Ther. 2018.
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[17]	Babatunde OA, Elegbede OE, Ayodele M, Fadare JO, Isinjaye AO, Ibirongbe DO, et al. Factors Affecting Treatment Outcomes of Tuberculosis in a Tertiary Health Center in Southwestern Nigeria. Int Rev Soc Sci Humanit. 2013.
[18]	Ohene SA, Bakker MI, Ojo J, Toonstra A, Awudi D, Klatser P. Extra-pulmonary tuberculosis: A retrospective study of patients in Accra, Ghana. PLoS One. 2019.
[19]	Duru CB, Uwakwe KA, Nnebue CC, Diwe KC, Merenu IA, Emerole CO, et al. Tuberculosis Treatment Outcomes and Determinants among Patients Treated in Hospitals in Imo State, Nigeria. OALib. 2016; 03: 1–17.
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APA Style

Daniel Yeboah Asiamah, Georgina Frimpong Siraa, Obed Kumi, Williams Domechele, Philip Teg-Nefaah Tabong. (2023). Types of Tuberculosis and Factors Associated with Treatment Outcome and Mortality in the Obuasi Municipality of Ashanti Region, Ghana. International Journal of Infectious Diseases and Therapy, 8(4), 127-131. https://doi.org/10.11648/j.ijidt.20230804.11

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ACS Style

Daniel Yeboah Asiamah; Georgina Frimpong Siraa; Obed Kumi; Williams Domechele; Philip Teg-Nefaah Tabong. Types of Tuberculosis and Factors Associated with Treatment Outcome and Mortality in the Obuasi Municipality of Ashanti Region, Ghana. Int. J. Infect. Dis. Ther. 2023, 8(4), 127-131. doi: 10.11648/j.ijidt.20230804.11

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AMA Style

Daniel Yeboah Asiamah, Georgina Frimpong Siraa, Obed Kumi, Williams Domechele, Philip Teg-Nefaah Tabong. Types of Tuberculosis and Factors Associated with Treatment Outcome and Mortality in the Obuasi Municipality of Ashanti Region, Ghana. Int J Infect Dis Ther. 2023;8(4):127-131. doi: 10.11648/j.ijidt.20230804.11

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@article{10.11648/j.ijidt.20230804.11,
  author = {Daniel Yeboah Asiamah and Georgina Frimpong Siraa and Obed Kumi and Williams Domechele and Philip Teg-Nefaah Tabong},
  title = {Types of Tuberculosis and Factors Associated with Treatment Outcome and Mortality in the Obuasi Municipality of Ashanti Region, Ghana},
  journal = {International Journal of Infectious Diseases and Therapy},
  volume = {8},
  number = {4},
  pages = {127-131},
  doi = {10.11648/j.ijidt.20230804.11},
  url = {https://doi.org/10.11648/j.ijidt.20230804.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijidt.20230804.11},
  abstract = {Introduction: Tuberculosis (TB) affects all persons in all countries of the world. Treatment outcomes remain a global indicator for measuring a country’s progress towards elimination of tuberculosis. Objective: The study was conducted to determine the distribution of TB by type and factors associated with treatment outcomes and mortality among a cohort of patients who received treatment for this disease between January 2015-December 2017 in the Obuasi municipality of Ghana. Results: The distribution of TB type were as follows: smear positive pulmonary TB (SPPTB), 50.0%, clinically diagnosed (smear negative) pulmonary TB 46.2%, extra-pulmonary TB 3.8% and 114 (19.83%) TB+HIV comorbidity. About 157 (27.30%) of TB patients were not screened for HIV. Successful treatment outcome rate was 77.20%. Unsuccessful treatment outcome rate was 22.80%; 7.90% defaulted, whereas 13.77% died, 0.90% treatment failure and 0.23% transferred out. In multivariable analysis, TB-HIV co-morbidity (aOR=3.37, 95% CI=1.50-7.57, p=0.003) was associated with unsuccessful treatment outcome and mortality (aOR=3.38, 95% CI=1.60-7.12, p=0.001). HIV infection reduced the likelihood of patient having successful treatment outcome whilst increasing the risk of mortality. Noncompliance with enhanced surveillance of screening all TB patients for HIV was common.},
 year = {2023}
}

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TY  - JOUR
T1  - Types of Tuberculosis and Factors Associated with Treatment Outcome and Mortality in the Obuasi Municipality of Ashanti Region, Ghana
AU  - Daniel Yeboah Asiamah
AU  - Georgina Frimpong Siraa
AU  - Obed Kumi
AU  - Williams Domechele
AU  - Philip Teg-Nefaah Tabong
Y1  - 2023/10/08
PY  - 2023
N1  - https://doi.org/10.11648/j.ijidt.20230804.11
DO  - 10.11648/j.ijidt.20230804.11
T2  - International Journal of Infectious Diseases and Therapy
JF  - International Journal of Infectious Diseases and Therapy
JO  - International Journal of Infectious Diseases and Therapy
SP  - 127
EP  - 131
PB  - Science Publishing Group
SN  - 2578-966X
UR  - https://doi.org/10.11648/j.ijidt.20230804.11
AB  - Introduction: Tuberculosis (TB) affects all persons in all countries of the world. Treatment outcomes remain a global indicator for measuring a country’s progress towards elimination of tuberculosis. Objective: The study was conducted to determine the distribution of TB by type and factors associated with treatment outcomes and mortality among a cohort of patients who received treatment for this disease between January 2015-December 2017 in the Obuasi municipality of Ghana. Results: The distribution of TB type were as follows: smear positive pulmonary TB (SPPTB), 50.0%, clinically diagnosed (smear negative) pulmonary TB 46.2%, extra-pulmonary TB 3.8% and 114 (19.83%) TB+HIV comorbidity. About 157 (27.30%) of TB patients were not screened for HIV. Successful treatment outcome rate was 77.20%. Unsuccessful treatment outcome rate was 22.80%; 7.90% defaulted, whereas 13.77% died, 0.90% treatment failure and 0.23% transferred out. In multivariable analysis, TB-HIV co-morbidity (aOR=3.37, 95% CI=1.50-7.57, p=0.003) was associated with unsuccessful treatment outcome and mortality (aOR=3.38, 95% CI=1.60-7.12, p=0.001). HIV infection reduced the likelihood of patient having successful treatment outcome whilst increasing the risk of mortality. Noncompliance with enhanced surveillance of screening all TB patients for HIV was common.
VL  - 8
IS  - 4
ER  -

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Author Information

Daniel Yeboah Asiamah

Department of Public Health, Faculty of Health and Allied Sciences, Catholic University College of Ghana, Sunyani, Ghana
Georgina Frimpong Siraa

Nutition Unit, District Health Directorate, Adansi Asokwa-Kumasi, Ghana
Obed Kumi

Fomena Health Centre, Kumasi, Ghana
Williams Domechele

Navrongo Health Research Centre, Ghana Health Service, Navrongo, Ghana
Philip Teg-Nefaah Tabong

School of Public Health, College of Health Sciences, University of Ghana, Accra, Ghana

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APA Style

Daniel Yeboah Asiamah, Georgina Frimpong Siraa, Obed Kumi, Williams Domechele, Philip Teg-Nefaah Tabong. (2023). Types of Tuberculosis and Factors Associated with Treatment Outcome and Mortality in the Obuasi Municipality of Ashanti Region, Ghana. International Journal of Infectious Diseases and Therapy, 8(4), 127-131. https://doi.org/10.11648/j.ijidt.20230804.11

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ACS Style

Daniel Yeboah Asiamah; Georgina Frimpong Siraa; Obed Kumi; Williams Domechele; Philip Teg-Nefaah Tabong. Types of Tuberculosis and Factors Associated with Treatment Outcome and Mortality in the Obuasi Municipality of Ashanti Region, Ghana. Int. J. Infect. Dis. Ther. 2023, 8(4), 127-131. doi: 10.11648/j.ijidt.20230804.11

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AMA Style

Daniel Yeboah Asiamah, Georgina Frimpong Siraa, Obed Kumi, Williams Domechele, Philip Teg-Nefaah Tabong. Types of Tuberculosis and Factors Associated with Treatment Outcome and Mortality in the Obuasi Municipality of Ashanti Region, Ghana. Int J Infect Dis Ther. 2023;8(4):127-131. doi: 10.11648/j.ijidt.20230804.11

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@article{10.11648/j.ijidt.20230804.11,
  author = {Daniel Yeboah Asiamah and Georgina Frimpong Siraa and Obed Kumi and Williams Domechele and Philip Teg-Nefaah Tabong},
  title = {Types of Tuberculosis and Factors Associated with Treatment Outcome and Mortality in the Obuasi Municipality of Ashanti Region, Ghana},
  journal = {International Journal of Infectious Diseases and Therapy},
  volume = {8},
  number = {4},
  pages = {127-131},
  doi = {10.11648/j.ijidt.20230804.11},
  url = {https://doi.org/10.11648/j.ijidt.20230804.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijidt.20230804.11},
  abstract = {Introduction: Tuberculosis (TB) affects all persons in all countries of the world. Treatment outcomes remain a global indicator for measuring a country’s progress towards elimination of tuberculosis. Objective: The study was conducted to determine the distribution of TB by type and factors associated with treatment outcomes and mortality among a cohort of patients who received treatment for this disease between January 2015-December 2017 in the Obuasi municipality of Ghana. Results: The distribution of TB type were as follows: smear positive pulmonary TB (SPPTB), 50.0%, clinically diagnosed (smear negative) pulmonary TB 46.2%, extra-pulmonary TB 3.8% and 114 (19.83%) TB+HIV comorbidity. About 157 (27.30%) of TB patients were not screened for HIV. Successful treatment outcome rate was 77.20%. Unsuccessful treatment outcome rate was 22.80%; 7.90% defaulted, whereas 13.77% died, 0.90% treatment failure and 0.23% transferred out. In multivariable analysis, TB-HIV co-morbidity (aOR=3.37, 95% CI=1.50-7.57, p=0.003) was associated with unsuccessful treatment outcome and mortality (aOR=3.38, 95% CI=1.60-7.12, p=0.001). HIV infection reduced the likelihood of patient having successful treatment outcome whilst increasing the risk of mortality. Noncompliance with enhanced surveillance of screening all TB patients for HIV was common.},
 year = {2023}
}

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TY  - JOUR
T1  - Types of Tuberculosis and Factors Associated with Treatment Outcome and Mortality in the Obuasi Municipality of Ashanti Region, Ghana
AU  - Daniel Yeboah Asiamah
AU  - Georgina Frimpong Siraa
AU  - Obed Kumi
AU  - Williams Domechele
AU  - Philip Teg-Nefaah Tabong
Y1  - 2023/10/08
PY  - 2023
N1  - https://doi.org/10.11648/j.ijidt.20230804.11
DO  - 10.11648/j.ijidt.20230804.11
T2  - International Journal of Infectious Diseases and Therapy
JF  - International Journal of Infectious Diseases and Therapy
JO  - International Journal of Infectious Diseases and Therapy
SP  - 127
EP  - 131
PB  - Science Publishing Group
SN  - 2578-966X
UR  - https://doi.org/10.11648/j.ijidt.20230804.11
AB  - Introduction: Tuberculosis (TB) affects all persons in all countries of the world. Treatment outcomes remain a global indicator for measuring a country’s progress towards elimination of tuberculosis. Objective: The study was conducted to determine the distribution of TB by type and factors associated with treatment outcomes and mortality among a cohort of patients who received treatment for this disease between January 2015-December 2017 in the Obuasi municipality of Ghana. Results: The distribution of TB type were as follows: smear positive pulmonary TB (SPPTB), 50.0%, clinically diagnosed (smear negative) pulmonary TB 46.2%, extra-pulmonary TB 3.8% and 114 (19.83%) TB+HIV comorbidity. About 157 (27.30%) of TB patients were not screened for HIV. Successful treatment outcome rate was 77.20%. Unsuccessful treatment outcome rate was 22.80%; 7.90% defaulted, whereas 13.77% died, 0.90% treatment failure and 0.23% transferred out. In multivariable analysis, TB-HIV co-morbidity (aOR=3.37, 95% CI=1.50-7.57, p=0.003) was associated with unsuccessful treatment outcome and mortality (aOR=3.38, 95% CI=1.60-7.12, p=0.001). HIV infection reduced the likelihood of patient having successful treatment outcome whilst increasing the risk of mortality. Noncompliance with enhanced surveillance of screening all TB patients for HIV was common.
VL  - 8
IS  - 4
ER  -

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