Positively Charged Water as a Plant Germination Stimulator
Issue:
Volume 9, Issue 1, March 2021
Pages:
1-7
Received:
2 February 2021
Accepted:
10 February 2021
Published:
23 February 2021
Abstract: There is a powerful electromagnetic force on Earth that moves positive charges up and negative charges down. This force participates in many phenomena occurring both in the Earth's atmosphere and on its surface, both in the grandiose and in the almost imperceptible. So, this force causes atmospheric discharges, both ascending currents of positive charges, namely, heavenly spirits and elves, and descending currents of negative charges, namely ordinary lightning. In addition, this force distributes the water within the clouds, directing the positively charged vapor upward and the negatively charged downward. Also, this force determines the ability of salts dissolved in positively charged water to form ascending plant-like crystals. All this made it possible to assume the participation of the same force in the distribution of water inside plants. In particular, it was assumed that under the action of this force, positively charged water moves upward inside the plants, and negatively charged water moves downward. Accordingly, it was assumed that positively charged water stimulates plant growth better than negatively charged water. Both of these assumptions have been verified experimentally. As expected, positively charged water stimulated the germination of various plants, while negatively charged water suppressed it. All this made it possible to propose a fundamentally new mechanism for the distribution of water inside vertical plants. In addition, other mechanisms were analyzed to explain the opposite effects of positively and negatively charged water on germinating plants.
Abstract: There is a powerful electromagnetic force on Earth that moves positive charges up and negative charges down. This force participates in many phenomena occurring both in the Earth's atmosphere and on its surface, both in the grandiose and in the almost imperceptible. So, this force causes atmospheric discharges, both ascending currents of positive c...
Show More
A Review on Biological Attributes of Momordica charantia
Zermina Khalid,
Syeda Mona Hassan,
Shahzad Sharif Mughal,
Syed Khurram Hassan,
Huma Hassan
Issue:
Volume 9, Issue 1, March 2021
Pages:
8-12
Received:
22 June 2020
Accepted:
2 November 2020
Published:
26 March 2021
Abstract: Momordica charantia is an herbal climber grown in tropical and subtropical regions, belonging to the Cucurbitaceae family. M. charantiacan be used as remedyagainst various diseases from ancient time. It has been used in various Asian traditional medicines for the treatment of cholera, bronchitis, anemia, blood diseases, ulcer, diarrhea, dysentery, gonorrhea rheumatism, gout, worms, colic, disease of liver and spleen, cancer and diabetes etc. The main constituents of M. charantia are triterpene, protein, steroid, alkaloid, inorganic, lipid, and phenolic compounds, which are responsible for biological and pharmacological activities including anti-diabetic, anti-cancerous and anti-tumorous, anti-microbial, anti-viral, anti-helmintic, antimalarial, anti-ulcerative and immunomodulatory. Combination of its Ayuervedic properties i.e. Gunna, Rasa and Virya (Dry, pungent, light, bitter and hot) makes it the real natures wonder. Hence the present study is planned to evaluate the biological characteristic like antioxident and antimicrobial properties of M. charantia. These activities will be sassessed by using different assay viz. total phenolics, total flavonols and scavenging assay for 1,1, diphenyl-2- picrylhydrazyl (DPPH). The antimicrobial activity will be evaluated by disc diffusion method.
Abstract: Momordica charantia is an herbal climber grown in tropical and subtropical regions, belonging to the Cucurbitaceae family. M. charantiacan be used as remedyagainst various diseases from ancient time. It has been used in various Asian traditional medicines for the treatment of cholera, bronchitis, anemia, blood diseases, ulcer, diarrhea, dysentery, ...
Show More
Roles of Integration of Multiple Simulation Technologies in Insights into Binding Mechanism of Inhibitors to BRD Family
Issue:
Volume 9, Issue 1, March 2021
Pages:
13-19
Received:
16 March 2021
Accepted:
30 March 2021
Published:
12 April 2021
Abstract: Insights into binding mechanism of inhibitors to targets are expected to provide a meaningfully theoretical guidance for design and development of effective inhibitors inhibiting of the activity of targets. It is well known that the bromodomain (BRD) family has been thought as a promising target utilized for treating various human diseases, such as inflammatory disorders, malignant tumors, acute myelogenous leukemia (AML), bone diseases, etc. In this work, we summarize the roles of integration of multiple simulation technologies in exploring atomic-level dynamics changes of the BRD family because of inhibitor bindings. Molecular dynamics (MD) simulations, binding free energy calculations, calculations of dynamics cross-correlation maps (DCCMs), and principal component (PC) analysis are integrated together to uncover binding modes of inhibitors to BRDs. The results obtained from binding free energy calculations can measure binding ability of inhibitors to BRDs, and explore the main driving forces of the binding of inhibitors to BRDs. The information stemming from PC analysis can reveal the changes in conformations, internal dynamics and movement patterns of BRDs due to inhibitor associations. Residue-based free energy decomposition method is wielded to unveil contributions of separate residues to inhibitor bindings, and explore the decisive factors that affect the bindings of inhibitors to BRDs.
Abstract: Insights into binding mechanism of inhibitors to targets are expected to provide a meaningfully theoretical guidance for design and development of effective inhibitors inhibiting of the activity of targets. It is well known that the bromodomain (BRD) family has been thought as a promising target utilized for treating various human diseases, such as...
Show More
